Literature DB >> 33572535

Briarenols W-Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908).

You-Ying Chen1,2, Yi-Lin Zhang2,3, Gene-Hsiang Lee4, Lun Kelvin Tsou5, Mingzi M Zhang6, Hsing-Pang Hsieh5,7,8, Jih-Jung Chen9, Chou-Yuan Ko10,11, Zhi-Hong Wen1,12, Ping-Jyun Sung1,2,3,13,14.   

Abstract

Briareum stechei is proven to be a rich source of 3,8-cyclized cembranoids (briarane) with a bicyclo[8.4.0] carbon core. In the present study, four previously unreported briaranes, briarenols W-Z (1-4), along with solenolide A (5), briarenolide M (6), briaexcavatolide F (7), and brianolide (8), were isolated and characterized through spectroscopic analysis, and the absolute configuration of 8 was corroborated by a single-crystal x-ray diffraction analysis. Briaranes 2 and 5 were found to induce significant inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophage cells by enhancing the expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins.

Entities:  

Keywords:  Briareum stechei; COX-2; briarane; briarenol; iNOS; inflammation

Mesh：

Substances：

Year:  2021        PMID： 33572535      PMCID： PMC7911717          DOI： 10.3390/md19020077

Source DB:  PubMed          Journal:  Mar Drugs        ISSN： 1660-3397            Impact factor:   5.118


  20 in total

1.  Absolute structure and absolute configuration.

Authors: 
Journal:  Acta Crystallogr A       Date:  1999-09-01       Impact factor: 2.290

Review 2.  Coral aquaculture to support drug discovery.

Authors:  Miguel C Leal; Ricardo Calado; Christopher Sheridan; Andrea Alimonti; Ronald Osinga
Journal:  Trends Biotechnol       Date:  2013-07-16       Impact factor: 19.536

3.  Excavatolides U-Z, new briarane diterpenes from the gorgonian briareum excavatum

Authors: 
Journal:  J Nat Prod       Date:  1999-10       Impact factor: 4.050

4.  Briarenol B, a New Polyoxygenated Briarane from the Octocoral Briareum excavatum.

Authors:  Mu-Jang Li; Yin-Di Su; Zuo-Jian Liao; Zhi-Hong Wen; Jui-Hsin Su; Yang-Chang Wu; Ping-Jyun Sung
Journal:  Nat Prod Commun       Date:  2017-02       Impact factor: 0.986

5.  Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats.

Authors:  Z Zhao; S R Chen; J C Eisenach; D W Busija; H L Pan
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

6.  Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp.

Authors:  J Kobayashi; J F Cheng; H Nakamura; Y Ohizumi; Y Tomotake; T Matsuzaki; K J Grace; R S Jacobs; Y Kato; L S Brinen
Journal:  Experientia       Date:  1991-05-15

7.  Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni.

Authors:  Yen-Hsuan Jean; Wu-Fu Chen; Chang-Yi Duh; Shi-Ying Huang; Chi-Hsin Hsu; Chan-Shing Lin; Chun-Sung Sung; I-Ming Chen; Zhi-Hong Wen
Journal:  Eur J Pharmacol       Date:  2007-09-20       Impact factor: 4.432

8.  Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi.

Authors:  Chi-Jen Tai; Jui-Hsin Su; Ming-Shyan Huang; Zhi-Hong Wen; Chang-Feng Dai; Jyh-Horng Sheu
Journal:  Mar Drugs       Date:  2011-10-19       Impact factor: 6.085

9.  Briarenols C-E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum.

Authors:  Nan-Fu Chen; Yin-Di Su; Tsong-Long Hwang; Zuo-Jian Liao; Kuan-Hao Tsui; Zhi-Hong Wen; Yang-Chang Wu; Ping-Jyun Sung
Journal:  Molecules       Date:  2017-03-17       Impact factor: 4.411

10.  Briarenols I-K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae).

Authors:  Thanh-Hao Huynh; Lee-Shing Fang; Yu-Hsin Chen; Bo-Rong Peng; You-Ying Chen; Li-Guo Zheng; Yu-Jen Wu; Zhi-Hong Wen; Jih-Jung Chen; Tzu-Chi Lin; Ping-Jyun Sung
Journal:  Molecules       Date:  2020-03-19       Impact factor: 4.411
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  2 in total

Review 1.  Cembranoids of Soft Corals: Recent Updates and Their Biological Activities.

Authors:  Marsya Yonna Nurrachma; Deamon Sakaraga; Ahmad Yogi Nugraha; Siti Irma Rahmawati; Asep Bayu; Linda Sukmarini; Akhirta Atikana; Anggia Prasetyoputri; Fauzia Izzati; Mega Ferdina Warsito; Masteria Yunovilsa Putra
Journal:  Nat Prod Bioprospect       Date:  2021-04-22

2.  Polyoxygenated Klysimplexane- and Eunicellin-Based Diterpenoids from the Gorgonian Briareum violaceum.

Authors:  Atallah F Ahmed; Yang Cheng; Chang-Feng Dai; Jyh-Horng Sheu
Journal:  Molecules       Date:  2021-05-28       Impact factor: 4.411
  2 in total

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