| Literature DB >> 32204524 |
Thanh-Hao Huynh1,2, Lee-Shing Fang3,4, Yu-Hsin Chen2, Bo-Rong Peng2, You-Ying Chen2, Li-Guo Zheng2, Yu-Jen Wu5, Zhi-Hong Wen6, Jih-Jung Chen7, Tzu-Chi Lin8, Ping-Jyun Sung1,2,6,9,10.
Abstract
Five 8,17-epoxybriaranes, including three new compounds-briarenols I-K (1-3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.Entities:
Keywords: Briareum excavatum; COX-2; anti-inflammatory; briarane; briarenol; iNOS
Year: 2020 PMID： 32204524 DOI： 10.3390/molecules25061405
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411