Literature DB >> 33572143

The Effect of Myristica fragrans on Texture Properties and Shelf-Life of Innovative Chewable Gel Tablets.

Inga Matulyte1,2, Akvile Mataraite3, Saule Velziene1, Jurga Bernatoniene1,2.   

Abstract

Chewable gel tablets are an underdeveloped subject, even though there are many simple chewable tablets and gummy candies in the food and pharmaceutical industries. Chewable gel tablets are not as sweet, they can have an active substance, pharmacological effect, and a value of nutrition. The aim of this study was to prepare gelatin-based chewable tablets with Myristica fragrans as a preservative and to determine the shelf-life variability depending on storage conditions, and to evaluate texture changes. Firmness and springiness of gel tablets were measured by a texture analyzer and compared between different storage conditions and the shelf-life of tablets was established by mold growing time. Chewable gel tablets were prepared by using silicone form. Mold was most likely to grow on tablets that have been packaged in squeezable bags (after 14 days 60% of all formulations had a mold, p < 0.05). The most stable tablets (over 180 days) were in sealed boxes and contained nutmeg essential oil or its solution, or ethanolic nutmeg extract. The gel tablets' firmness increased about 4 times when they were stored in opened plastic boxes and their springiness decreased about 1.65 times after 28 days in the mentioned conditions, p < 0.05. Nutmeg hydrolat had the highest influence on texture variation (p < 0.05).

Entities:  

Keywords:  chewable gel tablet; firmness; gel; gelatin; mold; nutmeg essential oil; pharmaceutical research; preservative; springiness

Year:  2021        PMID: 33572143      PMCID: PMC7915811          DOI: 10.3390/pharmaceutics13020238

Source DB:  PubMed          Journal:  Pharmaceutics        ISSN: 1999-4923            Impact factor:   6.321


  17 in total

1.  Soft, chewable gelatin-based pharmaceutical oral formulations: a technical approach.

Authors:  Morten J Dille; Magnus N Hattrem; Kurt I Draget
Journal:  Pharm Dev Technol       Date:  2017-06-02       Impact factor: 3.133

2.  Synergistic effects of nutmeg and citrus peel extracts in imparting oxidative stability in meat balls.

Authors:  Jyoti Nishad; Tanmay Kumar Koley; Eldho Varghese; Charanjit Kaur
Journal:  Food Res Int       Date:  2018-02-02       Impact factor: 6.475

3.  Microbial contamination of nonsterile pharmaceuticals in public hospital settings.

Authors:  Veronica Mugoyela; Kennedy D Mwambete
Journal:  Ther Clin Risk Manag       Date:  2010-10-05       Impact factor: 2.423

4.  Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken.

Authors:  R Firouzi; S S Shekarforoush; A H K Nazer; Z Borumand; A R Jooyandeh
Journal:  J Food Prot       Date:  2007-11       Impact factor: 2.077

5.  Enterococcus Species in the Oral Cavity: Prevalence, Virulence Factors and Antimicrobial Susceptibility.

Authors:  Edson Yukio Komiyama; Laura Soares Souto Lepesqueur; Cinthia Gomes Yassuda; Lakshman P Samaranayake; Nipuna B Parahitiyawa; Ivan Balducci; Cristiane Yumi Koga-Ito
Journal:  PLoS One       Date:  2016-09-15       Impact factor: 3.240

6.  Natural Ingredients-Based Gummy Bear Composition Designed According to Texture Analysis and Sensory Evaluation In Vivo.

Authors:  Ugnė Čižauskaitė; Greta Jakubaitytė; Virgilijus Žitkevičius; Giedrė Kasparavičienė
Journal:  Molecules       Date:  2019-04-11       Impact factor: 4.411

7.  GC-MS Analysis of the Composition of the Extracts and Essential Oil from Myristica fragrans Seeds Using Magnesium Aluminometasilicate as Excipient.

Authors:  Inga Matulyte; Mindaugas Marksa; Liudas Ivanauskas; Zenona Kalvėnienė; Robertas Lazauskas; Jurga Bernatoniene
Journal:  Molecules       Date:  2019-03-18       Impact factor: 4.411

8.  Application of Zataria multiflora Boiss. and Cinnamon zeylanicum essential oils as two natural preservatives in cake.

Authors:  Habibe Kordsardouei; Mohsen Barzegar; Mohamad Ali Sahari
Journal:  Avicenna J Phytomed       Date:  2013

Review 9.  Glycerol use in dairy diets: A systemic review.

Authors:  Ahmed E Kholif
Journal:  Anim Nutr       Date:  2019-06-22

10.  The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity.

Authors:  Inga Matulyte; Aiste Jekabsone; Lina Jankauskaite; Paulina Zavistanaviciute; Vytaute Sakiene; Elena Bartkiene; Modestas Ruzauskas; Dalia M Kopustinskiene; Antonello Santini; Jurga Bernatoniene
Journal:  Foods       Date:  2020-01-02
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  2 in total

Review 1.  Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design.

Authors:  Lucía Rodríguez-Pombo; Atheer Awad; Abdul W Basit; Carmen Alvarez-Lorenzo; Alvaro Goyanes
Journal:  Pharmaceutics       Date:  2022-08-18       Impact factor: 6.525

2.  Development of Innovative Chewable Gel Tablets Containing Nutmeg Essential Oil Microcapsules and Their Physical Properties Evaluation.

Authors:  Inga Matulyte; Mindaugas Marksa; Jurga Bernatoniene
Journal:  Pharmaceutics       Date:  2021-06-12       Impact factor: 6.321

  2 in total

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