| Literature DB >> 33572143 |
Inga Matulyte1,2, Akvile Mataraite3, Saule Velziene1, Jurga Bernatoniene1,2.
Abstract
Chewable gel tablets are an underdeveloped subject, even though there are many simple chewable tablets and gummy candies in the food and pharmaceutical industries. Chewable gel tablets are not as sweet, they can have an active substance, pharmacological effect, and a value of nutrition. The aim of this study was to prepare gelatin-based chewable tablets with Myristica fragrans as a preservative and to determine the shelf-life variability depending on storage conditions, and to evaluate texture changes. Firmness and springiness of gel tablets were measured by a texture analyzer and compared between different storage conditions and the shelf-life of tablets was established by mold growing time. Chewable gel tablets were prepared by using silicone form. Mold was most likely to grow on tablets that have been packaged in squeezable bags (after 14 days 60% of all formulations had a mold, p < 0.05). The most stable tablets (over 180 days) were in sealed boxes and contained nutmeg essential oil or its solution, or ethanolic nutmeg extract. The gel tablets' firmness increased about 4 times when they were stored in opened plastic boxes and their springiness decreased about 1.65 times after 28 days in the mentioned conditions, p < 0.05. Nutmeg hydrolat had the highest influence on texture variation (p < 0.05).Entities:
Keywords: chewable gel tablet; firmness; gel; gelatin; mold; nutmeg essential oil; pharmaceutical research; preservative; springiness
Year: 2021 PMID: 33572143 PMCID: PMC7915811 DOI: 10.3390/pharmaceutics13020238
Source DB: PubMed Journal: Pharmaceutics ISSN: 1999-4923 Impact factor: 6.321