Literature DB >> 33567779

Role of Exosomal miRNA in Bladder Cancer: A Promising Liquid Biopsy Biomarker.

Xuan-Mei Piao1, Eun-Jong Cha2,3, Seok Joong Yun1,4, Wun-Jae Kim1,3.   

Abstract

Bladder cancer (BCa) is the most prevalent neoplasia of the urinary tract. Unfortunately, limited improvements in effective BCa management have meant that it remains a challenging disease. Cystoscopy has been the gold standard for BCa diagnosis and surveillance for over two centuries but is an invasive and expensive approach. Recently, liquid biopsy has been identified as a promising field of cancer research, due to its noninvasiveness and ease of sampling. Liquid biopsy samples could provide comprehensive information regarding the genetic landscape of cancer and could track genomic evolution of the disease over time. Exosomes, which contain RNAs, DNAs, and proteins, are a potential source of tumor biomarkers in liquid biopsy samples. In particular, exosomal miRNAs (exomiRs) hold great promise as biomarkers for tumor development and progression. In this review, we provide an overview of liquid biopsy biomarkers, with a particular focus on the use of exomiRs as biomarkers of cancer, and summarize their clinical implications for BCa. Finally, we discuss the future perspectives of these biomarkers in cancer research.

Entities:  

Keywords:  bladder cancer; exosomal miRNAs; exosome; liquid biopsy

Mesh：

Substances：

Year:  2021        PMID： 33567779      PMCID： PMC7915637          DOI： 10.3390/ijms22041713

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  93 in total

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Authors:  Jessica A Weber; David H Baxter; Shile Zhang; David Y Huang; Kuo How Huang; Ming Jen Lee; David J Galas; Kai Wang
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2.  Malignant effusions and immunogenic tumour-derived exosomes.

Authors:  Fabrice Andre; Noel E C Schartz; Mojgan Movassagh; Caroline Flament; Patricia Pautier; Philippe Morice; Christophe Pomel; Catherine Lhomme; Bernard Escudier; Thierry Le Chevalier; Thomas Tursz; Sebastian Amigorena; Graca Raposo; Eric Angevin; Laurence Zitvogel
Journal:  Lancet       Date:  2002-07-27       Impact factor: 79.321

3.  A non-invasive miRNA based assay to detect bladder cancer in cell-free urine.

Authors:  Jessica De Long; Travis B Sullivan; John Humphrey; Tanya Logvinenko; Kelly A Summerhayes; Spencer Kozinn; Niall Harty; Ian C Summerhayes; John A Libertino; Antonia H Holway; Kimberly M Rieger-Christ
Journal:  Am J Transl Res       Date:  2015-11-15       Impact factor: 4.060

4.  Urinary cell-free microRNA biomarker could discriminate bladder cancer from benign hematuria.

Authors:  Xuan-Mei Piao; Pildu Jeong; Ye-Hwan Kim; Young Joon Byun; Yanjie Xu; Ho Won Kang; Yun-Sok Ha; Won Tae Kim; Jong-Young Lee; Seung Hwo Woo; Tae Gyun Kwon; Isaac Y Kim; Sung-Kwon Moon; Yung Hyun Choi; Eun-Jong Cha; Seok Joong Yun; Wun-Jae Kim
Journal:  Int J Cancer       Date:  2018-11-13       Impact factor: 7.396

5.  Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer.

Authors:  Gillian Vandekerkhove; Tilman Todenhöfer; Matti Annala; Werner J Struss; Amanda Wong; Kevin Beja; Elie Ritch; Sonal Brahmbhatt; Stanislav V Volik; Jörg Hennenlotter; Matti Nykter; Kim N Chi; Scott North; Arnulf Stenzl; Colin C Collins; Bernhard J Eigl; Peter C Black; Alexander W Wyatt
Journal:  Clin Cancer Res       Date:  2017-07-31       Impact factor: 12.531

6.  Serum microRNA expression signatures as novel noninvasive biomarkers for prediction and prognosis of muscle-invasive bladder cancer.

Authors:  Xiumei Jiang; Lutao Du; Weili Duan; Rui Wang; Keqiang Yan; Lili Wang; Juan Li; Guixi Zheng; Xin Zhang; Yongmei Yang; Chuanxin Wang
Journal:  Oncotarget       Date:  2016-06-14

Review 7.  Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy.

Authors:  Marco Tomasetti; Wan Lee; Lory Santarelli; Jiri Neuzil
Journal:  Exp Mol Med       Date:  2017-01-20       Impact factor: 8.718

8.  Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer.

Authors:  K M Patel; K E van der Vos; C G Smith; F Mouliere; D Tsui; J Morris; D Chandrananda; F Marass; D van den Broek; D E Neal; V J Gnanapragasam; T Forshew; B W van Rhijn; C E Massie; N Rosenfeld; M S van der Heijden
Journal:  Sci Rep       Date:  2017-07-17       Impact factor: 4.379

9.  Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes.

Authors:  Josephine Salimu; Jason Webber; Mark Gurney; Saly Al-Taei; Aled Clayton; Zsuzsanna Tabi
Journal:  J Extracell Vesicles       Date:  2017-09-03

10.  Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer.

Authors:  Xiao-Feng Wang; Xiao-Wei Zhang; Rui-Xi Hua; Yi-Qun Du; Ming-Zhu Huang; Yong Liu; Yu Fang Cheng; Wei-Jian Guo
Journal:  Oncotarget       Date:  2016-09-27
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1.  Stretchable broadband photo-sensor sheets for nonsampling, source-free, and label-free chemical monitoring by simple deformable wrapping.

Authors:  Kou Li; Teppei Araki; Ryogo Utaki; Yu Tokumoto; Meiling Sun; Satsuki Yasui; Naoko Kurihira; Yuko Kasai; Daichi Suzuki; Ruben Marteijn; Jaap M J den Toonder; Tsuyoshi Sekitani; Yukio Kawano
Journal:  Sci Adv       Date:  2022-05-11       Impact factor: 14.957

2.  Urinary exosomal microRNA-96-5p and microRNA-183-5p expression as potential biomarkers of bladder cancer.

Authors:  Amal S El-Shal; Sally M Shalaby; Safwat E Abouhashem; Eman H Abd Elbary; Samir Azazy; Nearmeen M Rashad; Walaa Sarhan
Journal:  Mol Biol Rep       Date:  2021-06-04       Impact factor: 2.316

Review 3.  The Role of Androgens and Androgen Receptor in Human Bladder Cancer.

Authors:  Elizabeth Martínez-Rojo; Laura Cristina Berumen; Guadalupe García-Alcocer; Jesica Escobar-Cabrera
Journal:  Biomolecules       Date:  2021-04-18

4.  Identification of a chromatin regulator signature and potential candidate drugs for bladder cancer.

Authors:  Ke Zhu; Xiaoqiang Liu; Wen Deng; Gongxian Wang; Bin Fu
Journal:  Hereditas       Date:  2022-02-07       Impact factor: 3.271

Review 5.  An Insight into miR-1290: An Oncogenic miRNA with Diagnostic Potential.

Authors:  Małgorzata Guz; Witold Jeleniewicz; Marek Cybulski
Journal:  Int J Mol Sci       Date:  2022-01-22       Impact factor: 5.923

Review 6.  Urine exosomes as biomarkers in bladder cancer diagnosis and prognosis: From functional roles to clinical significance.

Authors:  Nicholas Lee; Ashan Canagasingham; Mohit Bajaj; Ramesh Shanmugasundaram; Anthony Hutton; Joseph Bucci; Peter Graham; James Thompson; Jie Ni
Journal:  Front Oncol       Date:  2022-09-20       Impact factor: 5.738

Review 7.  Nanotechnology in Bladder Cancer: Diagnosis and Treatment.

Authors:  Mahmood Barani; Seyedeh Maryam Hosseinikhah; Abbas Rahdar; Leila Farhoudi; Rabia Arshad; Magali Cucchiarini; Sadanand Pandey
Journal:  Cancers (Basel)       Date:  2021-05-05       Impact factor: 6.639

8.  Differentially Expressed Extracellular Vesicle-Contained microRNAs before and after Transurethral Resection of Bladder Tumors.

Authors:  Olaf Strømme; Kathleen A Heck; Gaute Brede; Håvard T Lindholm; Marit Otterlei; Carl-Jørgen Arum
Journal:  Curr Issues Mol Biol       Date:  2021-06-04       Impact factor: 2.976
  8 in total

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