Leena Nahata1,2,3, Taylor M Dattilo4, Anna L Olsavsky4, Keagan G Lipak4, Stacy Whiteside5, Nicholas D Yeager5,6, Anthony Audino5,6, James L Klosky7, Joseph Rausch4, Amanda Saraf8, Sarah H O'Brien4,5,6, Gwendolyn P Quinn9, Cynthia A Gerhardt4,5,6. 1. The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. leena.nahata@nationwidechildrens.org. 2. Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. leena.nahata@nationwidechildrens.org. 3. Department of Pediatrics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA. leena.nahata@nationwidechildrens.org. 4. The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. 5. Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. 6. Department of Pediatrics, The Ohio State University College of Medicine, 370 W. 9th Avenue, Columbus, OH, 43210, USA. 7. Department of Pediatrics & Aflac Cancer and Blood Disorder Center, Emory University School of Medicine, Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA, 30322, USA. 8. Riley Children's Hospital, 700 Riley Hospital Drive, Indianapolis, IN, 46202, USA. 9. Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, 550 First Avenue, New York, NY, 10016, USA.
Abstract
PURPOSE: Over half of males experience fertility impairment after childhood cancer therapy, which often causes psychosocial distress. Yet, fertility preservation (FP) remains underutilized. The goals of this study were to determine the feasibility and impact of implementing a family-centered FP values clarification tool on sperm banking attempts among adolescent males newly diagnosed with cancer, and identify key determinants of banking attempts. METHODS: A prospective pilot study was conducted among families of males (12-25 years old), prior to cancer therapy. Thirty-nine of 41 families agreed to participate (95%); 98 participants (32 adolescents, 37 mothers, 29 fathers) completed the Family-centered Adolescent Sperm banking values clarification Tool (FAST). Analyses assessed the impact of the FAST on banking attempts and examined associations between demographic/medical characteristics, FAST subscales (perceived threat, benefits, barriers), and banking attempts. RESULTS: Twenty-three (59%) adolescents attempted to bank, compared to 8 adolescents (33%) during baseline assessment (p=.04). Significant associations were identified between banking attempts and adolescents' report of perceived threat (rpb=.45, p=.01) and benefits (rpb=.57, p=.01). Only mothers' proxy reports of adolescent perceived threat (rpb=.42, p=.01) and benefits (rpb=.47, p=.003) were associated with banking attempts, while fathers' self-reported perceived benefits (rpb=.43, p=.03), self-reported barriers (rpb=.49, p=.01), and proxy reports of adolescent perceived threat (rpb=.38, p=.04) and benefits (rpb=.59, p=.02) were associated with banking attempts. CONCLUSION: Adolescent sperm banking attempt rates significantly increased after implementation of a family-centered FP values clarification tool prior to cancer treatment. Findings underscore the importance of targeting both adolescents and their parents, particularly fathers, in FP efforts.
PURPOSE: Over half of males experience fertility impairment after childhood cancer therapy, which often causes psychosocial distress. Yet, fertility preservation (FP) remains underutilized. The goals of this study were to determine the feasibility and impact of implementing a family-centered FP values clarification tool on sperm banking attempts among adolescent males newly diagnosed with cancer, and identify key determinants of banking attempts. METHODS: A prospective pilot study was conducted among families of males (12-25 years old), prior to cancer therapy. Thirty-nine of 41 families agreed to participate (95%); 98 participants (32 adolescents, 37 mothers, 29 fathers) completed the Family-centered Adolescent Sperm banking values clarification Tool (FAST). Analyses assessed the impact of the FAST on banking attempts and examined associations between demographic/medical characteristics, FAST subscales (perceived threat, benefits, barriers), and banking attempts. RESULTS: Twenty-three (59%) adolescents attempted to bank, compared to 8 adolescents (33%) during baseline assessment (p=.04). Significant associations were identified between banking attempts and adolescents' report of perceived threat (rpb=.45, p=.01) and benefits (rpb=.57, p=.01). Only mothers' proxy reports of adolescent perceived threat (rpb=.42, p=.01) and benefits (rpb=.47, p=.003) were associated with banking attempts, while fathers' self-reported perceived benefits (rpb=.43, p=.03), self-reported barriers (rpb=.49, p=.01), and proxy reports of adolescent perceived threat (rpb=.38, p=.04) and benefits (rpb=.59, p=.02) were associated with banking attempts. CONCLUSION: Adolescent sperm banking attempt rates significantly increased after implementation of a family-centered FP values clarification tool prior to cancer treatment. Findings underscore the importance of targeting both adolescents and their parents, particularly fathers, in FP efforts.
Authors: Taylor L Morgan; Olivia E Clark; Stacy Whiteside; Anthony Audino; Nicholas D Yeager; James L Klosky; Sarah H O'Brien; Gwendolyn P Quinn; Cynthia A Gerhardt; Leena Nahata Journal: Psychooncology Date: 2019-02-15 Impact factor: 3.894
Authors: Leena Nahata; Taylor L Morgan; Amanda C Ferrante; Nicole M Caltabellotta; Nicholas D Yeager; Joseph R Rausch; Sarah H O'Brien; Gwendolyn P Quinn; Cynthia A Gerhardt Journal: J Adolesc Young Adult Oncol Date: 2019-02-28 Impact factor: 2.223
Authors: Mitesh S Patel; Susan C Day; Scott D Halpern; C William Hanson; Joseph R Martinez; Steven Honeywell; Kevin G Volpp Journal: JAMA Intern Med Date: 2016-06-01 Impact factor: 21.873
Authors: James L Klosky; Fang Wang; Kathryn M Russell; Hui Zhang; Jessica S Flynn; Lu Huang; Karen Wasilewski-Masker; Wendy Landier; Marcia Leonard; Karen H Albritton; Abha A Gupta; Jacqueline Casillas; Paul Colte; William H Kutteh; Leslie R Schover Journal: J Clin Oncol Date: 2017-10-04 Impact factor: 44.544
Authors: Anna L Olsavsky; Charleen I Theroux; Taylor M Dattilo; James L Klosky; Sarah H O'Brien; Gwendolyn P Quinn; Cynthia A Gerhardt; Leena Nahata Journal: Pediatr Blood Cancer Date: 2021-02-25 Impact factor: 3.838
Authors: Charis Stanek; Charleen I Theroux; Anna L Olsavsky; Kylie N Hill; Joseph R Rausch; Sarah H O'Brien; Gwendolyn P Quinn; Cynthia A Gerhardt; Leena Nahata Journal: PLoS One Date: 2022-02-16 Impact factor: 3.240
Authors: Leena Nahata; Anna Olsavsky; Taylor M Dattilo; Keagan G Lipak; Stacy Whiteside; Nicholas D Yeager; Anthony Audino; Joseph Rausch; James L Klosky; Sarah H O'Brien; Gwendolyn P Quinn; Cynthia A Gerhardt Journal: J Pediatr Psychol Date: 2021-10-18
Authors: Charleen I Theroux; Kylie N Hill; Anna L Olsavsky; James L Klosky; Nicholas D Yeager; Anthony Audino; Sarah H O'Brien; Gwendolyn P Quinn; Cynthia A Gerhardt; Leena Nahata Journal: Cancers (Basel) Date: 2021-07-16 Impact factor: 6.639