Literature DB >> 33559858

Interleukin (IL)-24: Reconfiguring the Tumor Microenvironment for Eliciting Antitumor Response.

Rajagopal Ramesh1,2,3, Rebaz Ahmed4,5, Anupama Munshi6,7.   

Abstract

Interleukin (IL)-24 is a member of the IL-10 family of cytokines. Due to its unique ability to function as both a tumor suppressor and cytokine, IL-24-based cancer therapy has been developed for treating a broad spectrum of human cancers. Majority of the studies reported to date have focused on establishing IL-24 as a cancer therapeutic by primarily focusing on tumor cell killing. However, the ability of IL-24 treatment on modulating the tumor microenvironment and immune response is underinvestigated. In this article, we summarize the biological and functional properties of IL-24 and the benefits of applying IL-24-based therapy for cancer.

Entities:  

Keywords:  Angiogenesis; Apoptosis; Cancer; Cancer stem cells; Cytokines; Glycosylation; IL-10; IL-19; IL-20 receptor; IL-22 receptor; IL-24; Immunity; Metastasis; Phosphorylation; Post-translational modification; Ubiquitination; mda-7

Mesh：

Substances：

Year:  2021        PMID： 33559858     DOI： 10.1007/978-3-030-55617-4_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  75 in total

Review 1.  IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation.

Authors:  Wenjun Ouyang; Anne O'Garra
Journal:  Immunity       Date:  2019-04-16       Impact factor: 31.745

2.  Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy.

Authors:  A M Mhashilkar; R D Schrock; M Hindi; J Liao; K Sieger; F Kourouma; X H Zou-Yang; E Onishi; O Takh; T S Vedvick; G Fanger; L Stewart; G J Watson; D Snary; P B Fisher; T Saeki; J A Roth; R Ramesh; S Chada
Journal:  Mol Med       Date:  2001-04       Impact factor: 6.354

3.  Interleukin 20: discovery, receptor identification, and role in epidermal function.

Authors:  H Blumberg; D Conklin; W F Xu; A Grossmann; T Brender; S Carollo; M Eagan; D Foster; B A Haldeman; A Hammond; H Haugen; L Jelinek; J D Kelly; K Madden; M F Maurer; J Parrish-Novak; D Prunkard; S Sexson; C Sprecher; K Waggie; J West; T E Whitmore; L Yao; M K Kuechle; B A Dale; Y A Chandrasekher
Journal:  Cell       Date:  2001-01-12       Impact factor: 41.582

4.  Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10).

Authors:  G Gallagher; H Dickensheets; J Eskdale; L S Izotova; O V Mirochnitchenko; J D Peat; N Vazquez; S Pestka; R P Donnelly; S V Kotenko
Journal:  Genes Immun       Date:  2000-10       Impact factor: 2.676

5.  Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity.

Authors:  Kerry L Fuson; Mingzhong Zheng; Molly Craxton; Abujiang Pataer; Rajagopal Ramesh; Sunil Chada; R Bryan Sutton
Journal:  J Biol Chem       Date:  2009-09-04       Impact factor: 5.157

6.  Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.

Authors:  E Y Huang; M T Madireddi; R V Gopalkrishnan; M Leszczyniecka; Z Su; I V Lebedeva; D Kang; H Jiang; J J Lin; D Alexandre; Y Chen; N Vozhilla; M X Mei; K A Christiansen; F Sivo; N I Goldstein; A B Mhashilkar; S Chada; E Huberman; S Pestka; P B Fisher
Journal:  Oncogene       Date:  2001-10-25       Impact factor: 9.867

Review 7.  mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic.

Authors:  Paul B Fisher; Rahul V Gopalkrishnan; Sunil Chada; Rajagopal Ramesh; Elizabeth A Grimm; Myrna R Rosenfeld; David T Curiel; Paul Dent
Journal:  Cancer Biol Ther       Date:  2003 Jul-Aug       Impact factor: 4.742

8.  Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.

Authors:  H Jiang; J J Lin; Z Z Su; N I Goldstein; P B Fisher
Journal:  Oncogene       Date:  1995-12-21       Impact factor: 9.867

Review 9.  MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic.

Authors:  Satoshi Inoue; Manish Shanker; Ryo Miyahara; Began Gopalan; Suraag Patel; Yasuhisa Oida; Cynthia D Branch; Anupama Munshi; Raymond E Meyn; Michael Andreeff; Fumihiro Tanaka; Abner M Mhashilkar; Sunil Chada; Rajagopal Ramesh
Journal:  Curr Gene Ther       Date:  2006-02       Impact factor: 4.391

10.  Editorial: The IL-20 Cytokines and Related Family Members in Immunity and Diseases.

Authors:  Jan Hendrik Niess; Rubén Francés
Journal:  Front Immunol       Date:  2019-08-20       Impact factor: 7.561
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  1 in total

Review 1.  Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer.

Authors:  Rajeswari Raguraman; Akhil Srivastava; Anupama Munshi; Rajagopal Ramesh
Journal:  Adv Drug Deliv Rev       Date:  2021-08-08       Impact factor: 15.470
  1 in total

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