| Literature DB >> 11163236 |
H Blumberg1, D Conklin, W F Xu, A Grossmann, T Brender, S Carollo, M Eagan, D Foster, B A Haldeman, A Hammond, H Haugen, L Jelinek, J D Kelly, K Madden, M F Maurer, J Parrish-Novak, D Prunkard, S Sexson, C Sprecher, K Waggie, J West, T E Whitmore, L Yao, M K Kuechle, B A Dale, Y A Chandrasekher.
Abstract
A structural, profile-based algorithm was used to identify interleukin 20 (IL-20), a novel IL-10 homolog. Chromosomal localization of IL-20 led to the discovery of an IL-10 family cytokine cluster. Overexpression of IL-20 in transgenic (TG) mice causes neonatal lethality with skin abnormalities including aberrant epidermal differentiation. Recombinant IL-20 protein stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line, demonstrating a direct action of this ligand. An IL-20 receptor was identified as a heterodimer of two orphan class II cytokine receptor subunits. Both receptor subunits are expressed in skin and are dramatically upregulated in psoriatic skin. Taken together, these results demonstrate a role in epidermal function and psoriasis for IL-20, a novel cytokine identified solely by bioinformatics analysis.Entities:
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Year: 2001 PMID： 11163236 DOI： 10.1016/s0092-8674(01)00187-8
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582