Simone Canovi1, Giulia Besutti2,3, Efrem Bonelli4,2, Valentina Iotti2, Marta Ottone5, Laura Albertazzi4, Alessandro Zerbini6, Pierpaolo Pattacini2, Paolo Giorgi Rossi5, Rossana Colla4, Tommaso Fasano4. 1. Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy. Simone.Canovi@ausl.re.it. 2. Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy. 3. Clinical and Experimental Medicine PhD program, University of Modena and Reggio Emilia, Modena, Italy. 4. Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy. 5. Epidemiology Unit, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy. 6. Laboratory of autoimmunity, allergology and innovative biotechnologies, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
Abstract
BACKGROUND: Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. METHODS: This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. RESULTS: Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. CONCLUSIONS: Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
BACKGROUND: Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19patients. METHODS: This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. RESULTS: Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. CONCLUSIONS:Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
Authors: Ahmed Ismail; Ahmed S Doghish; Walid F Elkhatib; Ahmed M Magdy; Eman E Mahmoud; Mona I Ahmed; Mahmoud A F Khalil Journal: PLoS One Date: 2022-07-08 Impact factor: 3.752