Literature DB >> 33553608

Roles of SDE2 and TIMELESS at active and stalled DNA replication forks.

Natalie Lo1, Julie Rageul1, Hyungjin Kim1,2.   

Abstract

The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains the integrity of the FPC, and together with TIM, protects stalled replication forks from nucleolytic degradation.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  BRCA1/BRCA2; DNA replication stress; Genome instability; SDE2; TIMELESS; fork protection complex

Year:  2020        PMID： 33553608      PMCID： PMC7849734          DOI： 10.1080/23723556.2020.1855053

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Maintaining genome stability at the replication fork.

Authors:  Dana Branzei; Marco Foiani
Journal:  Nat Rev Mol Cell Biol       Date:  2010-03       Impact factor: 94.444

2.  Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.

Authors:  Yves Pommier; Mark J O'Connor; Johann de Bono
Journal:  Sci Transl Med       Date:  2016-10-26       Impact factor: 17.956

Review 3.  Replication Fork Reversal: Players and Guardians.

Authors:  Annabel Quinet; Delphine Lemaçon; Alessandro Vindigni
Journal:  Mol Cell       Date:  2017-12-07       Impact factor: 17.970

4.  The many facets of the Tim-Tipin protein families' roles in chromosome biology.

Authors:  Ramsay J McFarlane; Saira Mian; Jacob Z Dalgaard
Journal:  Cell Cycle       Date:  2010-02-17       Impact factor: 4.534

5.  PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.

Authors:  Ukhyun Jo; Winson Cai; Jingming Wang; Yoojin Kwon; Alan D D'Andrea; Hyungjin Kim
Journal:  PLoS Genet       Date:  2016-12-01       Impact factor: 5.917

6.  Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks.

Authors:  Julie Rageul; Jennifer J Park; Ukhyun Jo; Alexandra S Weinheimer; Tri T M Vu; Hyungjin Kim
Journal:  Nucleic Acids Res       Date:  2019-05-07       Impact factor: 16.971

7.  Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.

Authors:  Julien N Bianco; Valérie Bergoglio; Yea-Lih Lin; Marie-Jeanne Pillaire; Anne-Lyne Schmitz; Julia Gilhodes; Amelie Lusque; Julien Mazières; Magali Lacroix-Triki; Theodoros I Roumeliotis; Jyoti Choudhary; Jérôme Moreaux; Jean-Sébastien Hoffmann; Hélène Tourrière; Philippe Pasero
Journal:  Nat Commun       Date:  2019-02-22       Impact factor: 14.919

Review 8.  Local and global functions of Timeless and Tipin in replication fork protection.

Authors:  Adam R Leman; Eishi Noguchi
Journal:  Cell Cycle       Date:  2012-09-17       Impact factor: 4.534

9.  Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork.

Authors:  Domagoj Baretić; Michael Jenkyn-Bedford; Valentina Aria; Giuseppe Cannone; Mark Skehel; Joseph T P Yeeles
Journal:  Mol Cell       Date:  2020-05-04       Impact factor: 19.328
  10 in total
  1 in total

1.  Comprehensive Effects of Flowering Locus T-Mediated Stem Growth in Tobacco.

Authors:  Jun Wu; Qiuhong Wu; Zhongjian Bo; Xuli Zhu; Junhui Zhang; Qingying Li; Wenqing Kong
Journal:  Front Plant Sci       Date:  2022-06-16       Impact factor: 6.627
  1 in total

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