Literature DB >> 33553606

P53 orchestrates a complex symphony of cellular processes during oncosuppression.

Liz J Valente1, Laura D Attardi1,2,3.   

Abstract

We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the TP53 (tumor protein p53) gene is so prevalent in human cancers.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  P53; cancer; cell biology; transformation; tumor suppression

Year:  2021        PMID： 33553606      PMCID： PMC7849744          DOI： 10.1080/23723556.2020.1852066

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Deconstructing networks of p53-mediated tumor suppression in vivo.

Authors:  Alyssa M Kaiser; Laura D Attardi
Journal:  Cell Death Differ       Date:  2017-11-03       Impact factor: 15.828

2.  Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

Authors:  S W Lowe; T Jacks; D E Housman; H E Ruley
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

3.  Ferroptosis as a p53-mediated activity during tumour suppression.

Authors:  Le Jiang; Ning Kon; Tongyuan Li; Shang-Jui Wang; Tao Su; Hanina Hibshoosh; Richard Baer; Wei Gu
Journal:  Nature       Date:  2015-03-18       Impact factor: 49.962

4.  Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts.

Authors:  Simona Parrinello; Enrique Samper; Ana Krtolica; Joshua Goldstein; Simon Melov; Judith Campisi
Journal:  Nat Cell Biol       Date:  2003-08       Impact factor: 28.824

Review 5.  Deciphering p53 signaling in tumor suppression.

Authors:  Stephano S Mello; Laura D Attardi
Journal:  Curr Opin Cell Biol       Date:  2017-11-28       Impact factor: 8.382

6.  DNA repair processes are critical mediators of p53-dependent tumor suppression.

Authors:  Ana Janic; Liz J Valente; Matthew J Wakefield; Leon Di Stefano; Liz Milla; Stephen Wilcox; Haoyu Yang; Lin Tai; Cassandra J Vandenberg; Andrew J Kueh; Shinsuke Mizutani; Margs S Brennan; Robyn L Schenk; Lisa M Lindqvist; Anthony T Papenfuss; Liam O'Connor; Andreas Strasser; Marco J Herold
Journal:  Nat Med       Date:  2018-06-11       Impact factor: 53.440

7.  Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest.

Authors:  H J Lin; V Eviner; G C Prendergast; E White
Journal:  Mol Cell Biol       Date:  1995-08       Impact factor: 4.272

Review 8.  Modeling Physiological Events in 2D vs. 3D Cell Culture.

Authors:  Kayla Duval; Hannah Grover; Li-Hsin Han; Yongchao Mou; Adrian F Pegoraro; Jeffery Fredberg; Zi Chen
Journal:  Physiology (Bethesda)       Date:  2017-07

Review 9.  Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia.

Authors:  Aude Carreau; Bouchra El Hafny-Rahbi; Agata Matejuk; Catherine Grillon; Claudine Kieda
Journal:  J Cell Mol Med       Date:  2011-06       Impact factor: 5.310

10.  p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.

Authors:  Liz J Valente; Amy Tarangelo; Albert Mao Li; Marwan Naciri; Nitin Raj; Anthony M Boutelle; Yang Li; Stephano Spano Mello; Kathryn Bieging-Rolett; Ralph J DeBerardinis; Jiangbin Ye; Scott J Dixon; Laura D Attardi
Journal:  J Cell Biol       Date:  2020-11-02       Impact factor: 10.539
  10 in total

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