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Literature DB >> 33553173

PLK-1 Regulation of Asymmetric Cell Division in the Early C. elegans Embryo.

Abstract

PLK1 is a conserved mitotic kinase that is essential for the entry into and progression through mitosis. In addition to its canonical mitotic functions, recent studies have characterized a critical role for PLK-1 in regulating the polarization and asymmetric division of the one-cell C. elegans embryo. Prior to cell division, PLK-1 regulates both the polarization of the PAR proteins at the cell cortex and the segregation of cell fate determinants in the cytoplasm. Following cell division, PLK-1 is preferentially inherited to one daughter cell where it acts to regulate the timing of centrosome separation and cell division. PLK1 also regulates cell polarity in asymmetrically dividing Drosophila neuroblasts and during mammalian planar cell polarity, suggesting it may act broadly to connect cell polarity and cell cycle mechanisms.

Entities: Chemical Disease Gene Species

Keywords: C. elegans; PAR proteins; PLK1 (Polo-like Kinase 1); asymmetric cell division (ACD); cell polarity

Year: 2021 PMID： 33553173 PMCID： PMC7859328 DOI： 10.3389/fcell.2020.632253

Source DB: PubMed Journal: Front Cell Dev Biol ISSN： 2296-634X

89 in total

1. Modeling protein dynamics in Caenorhabditis elegans embryos reveals that the PLK-1 gradient relies on weakly coupled reaction-diffusion mechanisms.

Authors: Sofia Barbieri; Aparna Nurni Ravi; Erik E Griffin; Monica Gotta
Journal: Proc Natl Acad Sci U S A Date: 2022-03-08 Impact factor: 12.779

1 in total

PLK-1 Regulation of Asymmetric Cell Division in the Early C. elegans Embryo.

1. Aurora-A Breaks Symmetry in Contractile Actomyosin Networks Independently of Its Role in Centrosome Maturation.

Review 2. The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates.

3. Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo.

Review 4. Targeting polo-like kinase 1 for cancer therapy.

5. Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos.

6. PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.

7. Single-molecule dynamics of the P granule scaffold MEG-3 in the Caenorhabditis elegans zygote.

8. Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion.

9. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.

10. Microtubules are involved in anterior-posterior axis formation in C. elegans embryos.

1. Modeling protein dynamics in Caenorhabditis elegans embryos reveals that the PLK-1 gradient relies on weakly coupled reaction-diffusion mechanisms.