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Literature DB >> 33551993

Clinical Potential of Extracellular Vesicles in Type 2 Diabetes.

Jie Liu^1,2,3, Xin Sun^1,2, Fu-Liang Zhang^1,2, Hang Jin^1,2, Xiu-Li Yan¹, Shuo Huang^1,2,3, Zhen-Ni Guo^1,2,3, Yi Yang^1,2,3.

Abstract

Type 2 diabetes (T2D) is a major public health disease which is increased in incidence and prevalence throughout the whole world. Insulin resistance (IR) in peripheral tissues and insufficient pancreatic β-cell mass and function have been recognized as primary mechanisms in the pathogenesis of T2D, while recently, systemic chronic inflammation resulting from obesity and a sedentary lifestyle has also gained considerable attention in T2D progression. Nowadays, accumulating evidence has revealed extracellular vesicles (EVs) as critical mediators promoting the pathogenesis of T2D. They can also be used in the diagnosis and treatment of T2D and its complications. In this review, we briefly introduce the basic concepts of EVs and their potential roles in the pathogenesis of T2D. Then, we discuss their diagnostic and therapeutic potentials in T2D and its complications, hoping to open new prospects for the management of T2D.

Entities: CellLine Chemical Disease Gene Species

Keywords: diagnosis; extracellular vesicles; mechanism; treatment; type 2 diabetes

Year: 2021 PMID： 33551993 PMCID： PMC7859486 DOI： 10.3389/fendo.2020.596811

Source DB: PubMed Journal: Front Endocrinol (Lausanne) ISSN： 1664-2392 Impact factor: 5.555

144 in total

Review 1. Inflammation and metabolic disorders.

Authors: Gökhan S Hotamisligil
Journal: Nature Date: 2006-12-14 Impact factor: 49.962

2. Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes.

Authors: Andrea Natali; Elena Toschi; Stephanie Baldeweg; Demetrio Ciociaro; Stefania Favilla; Luigi Saccà; Ele Ferrannini
Journal: Diabetes Date: 2006-04 Impact factor: 9.461

3. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.

Authors: Dongsheng Cai; Minsheng Yuan; Daniel F Frantz; Peter A Melendez; Lone Hansen; Jongsoon Lee; Steven E Shoelson
Journal: Nat Med Date: 2005-01-30 Impact factor: 53.440

4. Microvesicles enhance the mobility of human diabetic adipose tissue-derived mesenchymal stem cells in vitro and improve wound healing in vivo.

Authors: Nhu Thuy Trinh; Toshiharu Yamashita; Tran Cam Tu; Toshiki Kato; Kinuko Ohneda; Fujio Sato; Osamu Ohneda
Journal: Biochem Biophys Res Commun Date: 2016-04-07 Impact factor: 3.575

5. Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.

Authors: Petra Hirsova; Samar H Ibrahim; Anuradha Krishnan; Vikas K Verma; Steven F Bronk; Nathan W Werneburg; Michael R Charlton; Vijay H Shah; Harmeet Malhi; Gregory J Gores
Journal: Gastroenterology Date: 2016-01-05 Impact factor: 22.682

6. Physical exercise induces rapid release of small extracellular vesicles into the circulation.

Authors: Carsten Frühbeis; Susanne Helmig; Suzan Tug; Perikles Simon; Eva-Maria Krämer-Albers
Journal: J Extracell Vesicles Date: 2015-07-02

7. Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes.

Authors: Kanna Nagaishi; Yuka Mizue; Takako Chikenji; Miho Otani; Masako Nakano; Naoto Konari; Mineko Fujimiya
Journal: Sci Rep Date: 2016-10-10 Impact factor: 4.379

8. Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing.

Authors: Qijun Lv; Junfeng Deng; You Chen; Yizhen Wang; Bo Liu; Jie Liu
Journal: Mol Pharm Date: 2020-04-13 Impact factor: 4.939

9. An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells.

Authors: Kenta Kubota; Masako Nakano; Eiji Kobayashi; Yuka Mizue; Takako Chikenji; Miho Otani; Kanna Nagaishi; Mineko Fujimiya
Journal: PLoS One Date: 2018-09-21 Impact factor: 3.240

10. Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds.

Authors: Shi-Cong Tao; Bi-Yu Rui; Qi-Yang Wang; Ding Zhou; Yang Zhang; Shang-Chun Guo
Journal: Drug Deliv Date: 2018-11 Impact factor: 6.419

7 in total

Clinical Potential of Extracellular Vesicles in Type 2 Diabetes.

Review 1. Inflammation and metabolic disorders.

2. Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes.

3. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.

4. Microvesicles enhance the mobility of human diabetic adipose tissue-derived mesenchymal stem cells in vitro and improve wound healing in vivo.

5. Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.

6. Physical exercise induces rapid release of small extracellular vesicles into the circulation.

7. Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes.

8. Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing.

9. An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells.

10. Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds.

1. Insulin infusion decreases medium-sized extracellular vesicles in adults with metabolic syndrome.

Review 2. In vitro skeletal muscle models for type 2 diabetes.

3. IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity.

Review 4. Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications.

Review 5. Roles and mechanisms of exosomal non-coding RNAs in human health and diseases.

Review 6. Exosomal Proteins and Lipids as Potential Biomarkers for Lung Cancer Diagnosis, Prognosis, and Treatment.

7. RNF6 Targeted by miR-26a-5p Protects Pancreatic β-Cell Function Against Type 2 Diabetes.