Literature DB >> 19440234

p21 in cancer: intricate networks and multiple activities.

Tarek Abbas1, Anindya Dutta.   

Abstract

One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals. This Review focuses on recent advances in our understanding of the regulation of p21 and its biological functions with emphasis on its p53-independent tumour suppressor activities and paradoxical tumour-promoting activities, and their implications in cancer.

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Year:  2009        PMID： 19440234      PMCID： PMC2722839          DOI： 10.1038/nrc2657

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  230 in total

1.  A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.

Authors:  R Touitou; J Richardson; S Bose; M Nakanishi; J Rivett; M J Allday
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

2.  Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

Authors:  B P Zhou; Y Liao; W Xia; B Spohn; M H Lee; M C Hung
Journal:  Nat Cell Biol       Date:  2001-03       Impact factor: 28.824

3.  Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.

Authors:  L Rössig; A S Jadidi; C Urbich; C Badorff; A M Zeiher; S Dimmeler
Journal:  Mol Cell Biol       Date:  2001-08       Impact factor: 4.272

Review 4.  Regulation of the G2/M transition by p53.

Authors:  W R Taylor; G R Stark
Journal:  Oncogene       Date:  2001-04-05       Impact factor: 9.867

5.  Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus.

Authors:  D S Bae; S B Cho; Y J Kim; J D Whang; S Y Song; C S Park; D S Kim; J H Lee
Journal:  Gynecol Oncol       Date:  2001-06       Impact factor: 5.482

6.  p53, p21 and p27 protein expression in head and neck cancer and their prognostic value.

Authors:  N Kapranos; G P Stathopoulos; L Manolopoulos; E Kokka; C Papadimitriou; A Bibas; J Yiotakis; G Adamopoulos
Journal:  Anticancer Res       Date:  2001 Jan-Feb       Impact factor: 2.480

7.  A combination analysis of p53 and p21 in gastric carcinoma as a strong indicator for prognosis.

Authors:  M Ogawa; N Onoda; K Maeda; Y Kato; B Nakata; S M Kang; M Sowa; K Hirakawa
Journal:  Int J Mol Med       Date:  2001-05       Impact factor: 4.101

8.  Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

Authors:  J Martín-Caballero; J M Flores; P García-Palencia; M Serrano
Journal:  Cancer Res       Date:  2001-08-15       Impact factor: 12.701

Review 9.  Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer.

Authors:  A R Black; J D Black; J Azizkhan-Clifford
Journal:  J Cell Physiol       Date:  2001-08       Impact factor: 6.384

10.  Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.

Authors:  M Lebel; R D Cardiff; P Leder
Journal:  Cancer Res       Date:  2001-03-01       Impact factor: 12.701
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  1030 in total

Review 1.  Single-nucleotide polymorphisms in the p53 signaling pathway.

Authors:  Lukasz F Grochola; Jorge Zeron-Medina; Sophie Mériaux; Gareth L Bond
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-12-09       Impact factor: 10.005

2.  Cables1 complex couples survival signaling to the cell death machinery.

Authors:  Zhi Shi; Hae Ryon Park; Yuhong Du; Zijian Li; Kejun Cheng; Shi-Yong Sun; Zenggang Li; Haian Fu; Fadlo R Khuri
Journal:  Cancer Res       Date:  2014-10-31       Impact factor: 12.701

3.  p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies.

Authors:  Tanya Stoyanova; Nilotpal Roy; Shaumick Bhattacharjee; Dragana Kopanja; Ted Valli; Srilata Bagchi; Pradip Raychaudhuri
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

4.  Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions.

Authors:  Kristina Goetze; Michael Scholz; Gisela Taucher-Scholz; Wolfgang Mueller-Klieser
Journal:  Radiat Environ Biophys       Date:  2010-06-10       Impact factor: 1.925

5.  RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway.

Authors:  Xia Yi; Mei Hong; Bin Gui; Zhe Chen; Lei Li; Guojia Xie; Jing Liang; Xiaocheng Wang; Yongfeng Shang
Journal:  J Biol Chem       Date:  2012-04-30       Impact factor: 5.157

6.  Role of the translationally controlled tumor protein in DNA damage sensing and repair.

Authors:  Jie Zhang; Sonia M de Toledo; Badri N Pandey; Guozheng Guo; Debkumar Pain; Hong Li; Edouard I Azzam
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

7.  p21 overexpression sensitizes osteosarcoma U2OS cells to cisplatin via evoking caspase-3 and Bax/Bcl-2 cascade.

Authors:  Yong Ding; Yucai Wang; Jun Chen; Yunsheng Hu; Zhuo Cao; Pengcheng Ren; Yong Zhang
Journal:  Tumour Biol       Date:  2013-12-11

8.  The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells.

Authors:  Cory T Zumbar; Aisulu Usubalieva; Paul D King; Xiaohui Li; Caroline S Mifsud; Hailey M Dalton; Muge Sak; Sara Urio; William M Bryant; Joseph P McElroy; George Farmer; Norman L Lehman
Journal:  J Neurooncol       Date:  2018-02-02       Impact factor: 4.130

9.  Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function.

Authors:  L Palanikumar; Laura Karpauskaite; Mohamed Al-Sayegh; Ibrahim Chehade; Maheen Alam; Sarah Hassan; Debabrata Maity; Liaqat Ali; Mona Kalmouni; Yamanappa Hunashal; Jemil Ahmed; Tatiana Houhou; Shake Karapetyan; Zackary Falls; Ram Samudrala; Renu Pasricha; Gennaro Esposito; Ahmed J Afzal; Andrew D Hamilton; Sunil Kumar; Mazin Magzoub
Journal:  Nat Commun       Date:  2021-06-25       Impact factor: 14.919

10.  Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21.

Authors:  Nirmalya Basu; Sayanti Saha; Imran Khan; Subbaraya G Ramachandra; Sandhya S Visweswariah
Journal:  J Biol Chem       Date:  2013-11-11       Impact factor: 5.157
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