| Literature DB >> 33547317 |
Gloria Vergara-Diaz1, Jean-Francois Daneault1,2, Federico Parisi1, Chen Admati3, Christina Alfonso4, Matilde Bertoli1, Edoardo Bonizzoni1, Gabriela Ferreira Carvalho1, Gianluca Costante1, Eric Eduardo Fabara1, Naama Fixler3, Fatemah Noushin Golabchi1, John Growdon5, Stefano Sapienza1, Phil Snyder6, Shahar Shpigelman3, Lewis Sudarsky7, Margaret Daeschler8, Lauren Bataille8, Solveig K Sieberts6, Larsson Omberg6, Steven Moore4,9, Paolo Bonato10,11.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Dyskinesia and motor fluctuations are complications of PD medications. An objective measure of on/off time with/without dyskinesia has been sought for some time because it would facilitate the titration of medications. The objective of the dataset herein presented is to assess if wearable sensor data can be used to generate accurate estimates of limb-specific symptom severity. Nineteen subjects with PD experiencing motor fluctuations were asked to wear a total of five wearable sensors on both forearms and shanks, as well as on the lower back. Accelerometer data was collected for four days, including two laboratory visits lasting 3 to 4 hours each while the remainder of the time was spent at home and in the community. During the laboratory visits, subjects performed a battery of motor tasks while clinicians rated limb-specific symptom severity. At home, subjects were instructed to use a smartphone app that guided the periodic performance of a set of motor tasks.Entities:
Year: 2021 PMID: 33547317 PMCID: PMC7864964 DOI: 10.1038/s41597-021-00831-z
Source DB: PubMed Journal: Sci Data ISSN: 2052-4463 Impact factor: 6.444