| Literature DB >> 33547309 |
Jean-Francois Daneault1,2, Gloria Vergara-Diaz1, Federico Parisi1, Chen Admati3, Christina Alfonso4, Matilde Bertoli1, Edoardo Bonizzoni1, Gabriela Ferreira Carvalho1, Gianluca Costante1, Eric Eduardo Fabara1, Naama Fixler3, Fatemah Noushin Golabchi1, John Growdon5, Stefano Sapienza1, Phil Snyder6, Shahar Shpigelman3, Lewis Sudarsky7, Margaret Daeschler8, Lauren Bataille8, Solveig K Sieberts6, Larsson Omberg6, Steven Moore4,9, Paolo Bonato10,11.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder associated with motor and non-motor symptoms. Current treatments primarily focus on managing motor symptom severity such as tremor, bradykinesia, and rigidity. However, as the disease progresses, treatment side-effects can emerge such as on/off periods and dyskinesia. The objective of the Levodopa Response Study was to identify whether wearable sensor data can be used to objectively quantify symptom severity in individuals with PD exhibiting motor fluctuations. Thirty-one subjects with PD were recruited from 2 sites to participate in a 4-day study. Data was collected using 2 wrist-worn accelerometers and a waist-worn smartphone. During Days 1 and 4, a portion of the data was collected in the laboratory while subjects performed a battery of motor tasks as clinicians rated symptom severity. The remaining of the recordings were performed in the home and community settings. To our knowledge, this is the first dataset collected using wearable accelerometers with specific focus on individuals with PD experiencing motor fluctuations that is made available via an open data repository.Entities:
Year: 2021 PMID: 33547309 PMCID: PMC7865022 DOI: 10.1038/s41597-021-00830-0
Source DB: PubMed Journal: Sci Data ISSN: 2052-4463 Impact factor: 6.444