| Literature DB >> 33547074 |
Gerda Kildisiute1, Waleed M Kholosy2, Matthew D Young3, Kenny Roberts1, Rasa Elmentaite1, Sander R van Hooff2, Clarissa N Pacyna1, Eleonora Khabirova1, Alice Piapi4, Christine Thevanesan4, Eva Bugallo-Blanco4, Christina Burke4, Lira Mamanova1, Kaylee M Keller2, Karin P S Langenberg-Ververgaert2, Philip Lijnzaad2, Thanasis Margaritis2, Frank C P Holstege2, Michelle L Tas2, Marc H W A Wijnen2, Max M van Noesel2, Ignacio Del Valle4, Giuseppe Barone5, Reinier van der Linden6, Catriona Duncan5, John Anderson4,5, John C Achermann4, Muzlifah Haniffa1,7,8, Sarah A Teichmann1, Dyanne Rampling5, Neil J Sebire5, Xiaoling He9,10, Ronald R de Krijger2,11, Roger A Barker9,10, Kerstin B Meyer1, Omer Bayraktar1, Karin Straathof12,5, Jan J Molenaar13, Sam Behjati3,14,15.
Abstract
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cells by comparing cancer (n = 19,723) with normal fetal adrenal single-cell transcriptomes (n = 57,972). Our principal finding was that the neuroblastoma cancer cell resembled fetal sympathoblasts, but no other fetal adrenal cell type. The sympathoblastic state was a universal feature of neuroblastoma cells, transcending cell cluster diversity, individual patients, and clinical phenotypes. We substantiated our findings in 650 neuroblastoma bulk transcriptomes and by integrating canonical features of the neuroblastoma genome with transcriptional signals. Overall, our observations indicate that a pan-neuroblastoma cancer cell state exists, which may be attractive for novel immunotherapeutic and targeted avenues.Entities:
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Year: 2021 PMID： 33547074 PMCID： PMC7864567 DOI： 10.1126/sciadv.abd3311
Source DB: PubMed Journal: Sci Adv ISSN： 2375-2548 Impact factor: 14.136