Yanbin Zhu1,2,3, Wei Chen1,2,3, Junyong Li1,2,3, Kuo Zhao1,2,3, Junzhe Zhang1,2,3, Hongyu Meng1,2,3, Yingze Zhang4,5,6,7,8, Qi Zhang9,10,11. 1. Department of Orthopaedic Surgery, The 3rd Hospital of Hebei Medical University, NO.139 Ziqiang Road, Shijiazhuang, 050051, Hebei, People's Republic of China. 2. Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, 050051, Hebei, People's Republic of China. 3. Orthopaedic Institution of Hebei Province, Shijiazhuang, 050051, Hebei, People's Republic of China. 4. Department of Orthopaedic Surgery, The 3rd Hospital of Hebei Medical University, NO.139 Ziqiang Road, Shijiazhuang, 050051, Hebei, People's Republic of China. drzhang2013@126.com. 5. Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, 050051, Hebei, People's Republic of China. drzhang2013@126.com. 6. Orthopaedic Institution of Hebei Province, Shijiazhuang, 050051, Hebei, People's Republic of China. drzhang2013@126.com. 7. Chinese Academy of Engineering, Beijing, 100088, People's Republic of China. drzhang2013@126.com. 8. NHC Key Laboratory of Intelligent Orthopeadic Equipment, Shijiazhuang, Hebei, 050051, P.R. China. drzhang2013@126.com. 9. Department of Orthopaedic Surgery, The 3rd Hospital of Hebei Medical University, NO.139 Ziqiang Road, Shijiazhuang, 050051, Hebei, People's Republic of China. zq_19865@163.com. 10. Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, 050051, Hebei, People's Republic of China. zq_19865@163.com. 11. Orthopaedic Institution of Hebei Province, Shijiazhuang, 050051, Hebei, People's Republic of China. zq_19865@163.com.
Abstract
BACKGROUND: There is still lack of data on deep vein thrombosis (DVT) following bone trauma. This study aimed to determine the epidemiologic characteristics of deep venous thrombosis (DVT) of lower extremities following tibial plateau fractures. METHODS: Retrospective analysis of prospectively collected data on patients presenting with tibial plateau fractures between October 2014 and December 2018 was conducted. Duplex ultrasonography (DUS) was routinely used to screen for preoperative DVT of bilateral lower extremities. Data on demographics, comorbidities, injury-related data, and laboratory biomarkers at admission were collected. Univariate analyses and multivariate logistic regression analyses were used to identify the independent risk factors associated with DVT. RESULTS: A total of 1179 patients were included, among whom 192 (16.3%) had a preoperative DVT, with incidence rate of 1.0% for proximal and 15.3% for distal DVT. The average interval between fracture occurrence and diagnosis of DVT was 3.5 days (median, 2 days), ranging from 0 to 19 days. DVT involved the injured extremity in 166 (86.4%) patients, both the injured and uninjured extremities in 14 patients (7.3%) and only the uninjured extremity in 12 patients (6.3%). Six risk factors were identified to be associated with DVT, including gender (male vs female), hypertension, open fracture, alkaline phosphatase > 100 u/L, sodium concentration < 135 mmol/L, and D-dimer > 0.5 mg/L. CONCLUSION: These epidemiologic data are conducive to the individualized assessment, risk stratification, and development of targeted prevention programs.
BACKGROUND: There is still lack of data on deep vein thrombosis (DVT) following bone trauma. This study aimed to determine the epidemiologic characteristics of deep venous thrombosis (DVT) of lower extremities following tibial plateau fractures. METHODS: Retrospective analysis of prospectively collected data on patients presenting with tibial plateau fractures between October 2014 and December 2018 was conducted. Duplex ultrasonography (DUS) was routinely used to screen for preoperative DVT of bilateral lower extremities. Data on demographics, comorbidities, injury-related data, and laboratory biomarkers at admission were collected. Univariate analyses and multivariate logistic regression analyses were used to identify the independent risk factors associated with DVT. RESULTS: A total of 1179 patients were included, among whom 192 (16.3%) had a preoperative DVT, with incidence rate of 1.0% for proximal and 15.3% for distal DVT. The average interval between fracture occurrence and diagnosis of DVT was 3.5 days (median, 2 days), ranging from 0 to 19 days. DVT involved the injured extremity in 166 (86.4%) patients, both the injured and uninjured extremities in 14 patients (7.3%) and only the uninjured extremity in 12 patients (6.3%). Six risk factors were identified to be associated with DVT, including gender (male vs female), hypertension, open fracture, alkaline phosphatase > 100 u/L, sodium concentration < 135 mmol/L, and D-dimer > 0.5 mg/L. CONCLUSION: These epidemiologic data are conducive to the individualized assessment, risk stratification, and development of targeted prevention programs.
Entities:
Keywords:
Deep venous thrombosis; Epidemiology; Risk factors; Tibial plateau fractures
Authors: Lasse J Lapidus; Sari Ponzer; Anders Elvin; Catharina Levander; Gerd Lärfars; Stefan Rosfors; Edin de Bri Journal: Acta Orthop Date: 2007-08 Impact factor: 3.717
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