Clémence Baudin1,2, Marie Lefèvre1,3, Wolfgang Babisch4, Ennio Cadum5, Patricia Champelovier6, Konstantina Dimakopoulou7, Danny Houthuijs8, Jacques Lambert6,9, Bernard Laumon10, Göran Pershagen11, Stephen Stansfeld12, Venetia Velonaki13, Anna L Hansell1,14, Anne-Sophie Evrard15. 1. Univ Lyon, Univ Gustave Eiffel, IFSTTAR, Univ Lyon 1, Umrestte, UMR T_9405, Bron, France. 2. Now at: Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France. 3. Now at: Technical Agency for Information on Hospital Care, Lyon, France. 4. Currently retired (formerly Federal Environment Agency), Berlin, Germany. 5. Environmental Health Unit, Agency for Health Protection, Pavia, Italy. 6. Univ Gustave Eiffel, IFSTTAR, AME-DCM, Bron, France. 7. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece. 8. National Institute for Public Health and the Environment, Bilthoven, the Netherlands. 9. Currently retired, Villeurbanne, France. 10. Univ Gustave Eiffel, IFSTTAR, TS2, Bron, France. 11. Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. 12. Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London, UK. 13. Nurses School, National and Kapodistrian University of Athens, Athens, Greece. 14. Centre for Environmental Health and Sustainability, University of Leicester, Leicester, UK. 15. Univ Lyon, Univ Gustave Eiffel, IFSTTAR, Univ Lyon 1, Umrestte, UMR T_9405, Bron, France. anne-sophie.evrard@univ-eiffel.fr.
Abstract
BACKGROUND: Few studies have considered aircraft noise annoyance and noise sensitivity in analyses of the health effects of aircraft noise, especially in relation to medication use. This study aims to investigate the moderating and mediating role of these two factors in the relationship between aircraft noise levels and medication use among 5860 residents of ten European airports included in the HYENA and DEBATS studies. METHODS: Information on aircraft noise annoyance, noise sensitivity, medication use, and demographic, socio-economic and lifestyle factors was collected during a face-to-face interview at home. Medication was coded according to the Anatomical Therapeutic Chemical (ATC) classification. Outdoor aircraft noise exposure was estimated by linking the participant's home address to noise contours using Geographical Information Systems (GIS) methods. Logistic regressions with adjustment for potential confounding factors were used. In addition, Baron and Kenny's recommendations were followed to investigate the moderating and mediating effects of aircraft noise annoyance and noise sensitivity. RESULTS: A significant association was found between aircraft noise levels at night and antihypertensive medication only in the UK (OR = 1.43, 95%CI 1.19-1.73 for a 10 dB(A)-increase in Lnight). No association was found with other medications. Aircraft noise annoyance was significantly associated with the use of antihypertensive medication (OR = 1.33, 95%CI 1.14-1.56), anxiolytics (OR = 1.48, 95%CI 1.08-2.05), hypnotics and sedatives (OR = 1.60, 95%CI 1.07-2.39), and antasthmatics (OR = 1.44, 95%CI 1.07-1.96), with no difference between countries. Noise sensitivity was significantly associated with almost all medications, with the exception of the use of antasthmatics, showing an increase in ORs with the level of noise sensitivity, with differences in ORs among countries only for the use of antihypertensive medication. The results also suggested a mediating role of aircraft noise annoyance and a modifying role of both aircraft noise annoyance and noise sensitivity in the association between aircraft noise levels and medication use. CONCLUSIONS: The present study is consistent with the results of the small number of studies available to date suggesting that both aircraft noise annoyance and noise sensitivity should be taken into account in analyses of the health effects of exposure to aircraft noise.
BACKGROUND: Few studies have considered aircraft noise annoyance and noise sensitivity in analyses of the health effects of aircraft noise, especially in relation to medication use. This study aims to investigate the moderating and mediating role of these two factors in the relationship between aircraft noise levels and medication use among 5860 residents of ten European airports included in the HYENA and DEBATS studies. METHODS: Information on aircraft noise annoyance, noise sensitivity, medication use, and demographic, socio-economic and lifestyle factors was collected during a face-to-face interview at home. Medication was coded according to the Anatomical Therapeutic Chemical (ATC) classification. Outdoor aircraft noise exposure was estimated by linking the participant's home address to noise contours using Geographical Information Systems (GIS) methods. Logistic regressions with adjustment for potential confounding factors were used. In addition, Baron and Kenny's recommendations were followed to investigate the moderating and mediating effects of aircraft noise annoyance and noise sensitivity. RESULTS: A significant association was found between aircraft noise levels at night and antihypertensive medication only in the UK (OR = 1.43, 95%CI 1.19-1.73 for a 10 dB(A)-increase in Lnight). No association was found with other medications. Aircraft noise annoyance was significantly associated with the use of antihypertensive medication (OR = 1.33, 95%CI 1.14-1.56), anxiolytics (OR = 1.48, 95%CI 1.08-2.05), hypnotics and sedatives (OR = 1.60, 95%CI 1.07-2.39), and antasthmatics (OR = 1.44, 95%CI 1.07-1.96), with no difference between countries. Noise sensitivity was significantly associated with almost all medications, with the exception of the use of antasthmatics, showing an increase in ORs with the level of noise sensitivity, with differences in ORs among countries only for the use of antihypertensive medication. The results also suggested a mediating role of aircraft noise annoyance and a modifying role of both aircraft noise annoyance and noise sensitivity in the association between aircraft noise levels and medication use. CONCLUSIONS: The present study is consistent with the results of the small number of studies available to date suggesting that both aircraft noise annoyance and noise sensitivity should be taken into account in analyses of the health effects of exposure to aircraft noise.
Authors: Clémence Baudin; Marie Lefèvre; Wolfgang Babisch; Ennio Cadum; Patricia Champelovier; Konstantina Dimakopoulou; Danny Houthuijs; Jacques Lambert; Bernard Laumon; Göran Pershagen; Stephen Stansfeld; Venetia Velonaki; Anna Hansell; Anne-Sophie Evrard Journal: Environ Res Date: 2020-09-10 Impact factor: 6.498
Authors: Wolfgang Babisch; Göran Pershagen; Jenny Selander; Danny Houthuijs; Oscar Breugelmans; Ennio Cadum; Federica Vigna-Taglianti; Klea Katsouyanni; Alexandros S Haralabidis; Konstantina Dimakopoulou; Panayota Sourtzi; Sarah Floud; Anna L Hansell Journal: Sci Total Environ Date: 2013-03-15 Impact factor: 7.963
Authors: Xiangpu Gong; Benjamin Fenech; Claire Blackmore; Yingxin Chen; Georgia Rodgers; John Gulliver; Anna L Hansell Journal: Int J Environ Res Public Health Date: 2022-02-25 Impact factor: 3.390