Henshaw Mandi1,2, Bekolo Cavin Epie3, Agnes Eyoh4, Sindhiya Jan5, Sue Ann Costa Clemens6, Ralf Clemens6, Solomon Yimer7. 1. Coalition for Epidemic Preparedness Innovations CEPI, Oslo, Norway. mhenshawnet@gmail.com. 2. Institute for Public Health, University of Siena, Siena, Italy. mhenshawnet@gmail.com. 3. Department of Public Health, University of Dschang, Dschang, Cameroon. 4. National Early Infant Reference Laboratory, Mutengene, Cameroon. 5. Vismederi srl, Siena, Italy. 6. Institute for Public Health, University of Siena, Siena, Italy. 7. Coalition for Epidemic Preparedness Innovations CEPI, Oslo, Norway.
Abstract
BACKGROUND: The respiratory syncytial virus (RSV) has been established as a leading cause of acute lower respiratory illness (ALRI) in infants and children. In 2015, the global disease burden (GBD) study estimated that the overall RSV-ALRI mortality could be as high as 118,200, with most death occurring in low- and middle-incomes countries (LMIC). This study aimed to assess the burden of RSV infection among children less than 2 years with acute respiratory infections (ARI) in the Littoral region of Cameroon. METHODS: We carried out a cross-sectional study in seven health centres in the Littoral region of Cameroon. Venous blood was collected using serum separation tubes from eligible children who visited these health centres with acute respiratory infections. ELISA (Enzyme-linked immunosorbent assay) testing was used to assess the seroprevalence of anti-IgM RSV for the total population and by selected demographic and health parameters and potential risk factors. RESULTS: The overall RSV-associated ARI seroprevalence was 33% (95%CI:23.6-42.3; 33/100 children). The only demographic factor significantly associated with RSV acquisition was age of 6 months and below (odds ratio: 7.54 (2.62, 23.36); p = 0.000). Children who were clinically diagnosed to be concomitantly infected with malaria had a lower risk of RSV infection (odds ratio: 0.38 (0.14, 0.95; P = 0.03). CONCLUSIONS: The RSV burden is high among children less than 2 years with ARI in the Littoral region of Cameroon. There is a need for an effective public health RSV surveillance system with standard laboratory techniques and equipment to better understand the RSV disease age-specific incidence, seasonality, risk factors and RSV burden among patients in communities in Cameroon.
BACKGROUND: The respiratory syncytial virus (RSV) has been established as a leading cause of acute lower respiratory illness (ALRI) in infants and children. In 2015, the global disease burden (GBD) study estimated that the overall RSV-ALRI mortality could be as high as 118,200, with most death occurring in low- and middle-incomes countries (LMIC). This study aimed to assess the burden of RSV infection among children less than 2 years with acute respiratory infections (ARI) in the Littoral region of Cameroon. METHODS: We carried out a cross-sectional study in seven health centres in the Littoral region of Cameroon. Venous blood was collected using serum separation tubes from eligible children who visited these health centres with acute respiratory infections. ELISA (Enzyme-linked immunosorbent assay) testing was used to assess the seroprevalence of anti-IgM RSV for the total population and by selected demographic and health parameters and potential risk factors. RESULTS: The overall RSV-associated ARI seroprevalence was 33% (95%CI:23.6-42.3; 33/100 children). The only demographic factor significantly associated with RSV acquisition was age of 6 months and below (odds ratio: 7.54 (2.62, 23.36); p = 0.000). Children who were clinically diagnosed to be concomitantly infected with malaria had a lower risk of RSV infection (odds ratio: 0.38 (0.14, 0.95; P = 0.03). CONCLUSIONS: The RSV burden is high among children less than 2 years with ARI in the Littoral region of Cameroon. There is a need for an effective public health RSV surveillance system with standard laboratory techniques and equipment to better understand the RSV disease age-specific incidence, seasonality, risk factors and RSV burden among patients in communities in Cameroon.
Authors: Susan E Robertson; Anna Roca; Pedro Alonso; Eric A F Simoes; Cissy B Kartasasmita; David O Olaleye; Georgina N Odaibo; Mark Collinson; Marietjie Venter; Yuwei Zhu; Peter F Wright Journal: Bull World Health Organ Date: 2005-01-05 Impact factor: 9.408
Authors: Pablo Obando-Pacheco; Antonio José Justicia-Grande; Irene Rivero-Calle; Carmen Rodríguez-Tenreiro; Peter Sly; Octavio Ramilo; Asunción Mejías; Eugenio Baraldi; Nikolaos G Papadopoulos; Harish Nair; Marta C Nunes; Leyla Kragten-Tabatabaie; Terho Heikkinen; Anne Greenough; Renato T Stein; Paolo Manzoni; Louis Bont; Federico Martinón-Torres Journal: J Infect Dis Date: 2018-04-11 Impact factor: 5.226
Authors: Karen Bohmwald; Catalina A Andrade; Nicolás M S Gálvez; Valentina P Mora; José T Muñoz; Alexis M Kalergis Journal: Front Cell Neurosci Date: 2021-11-30 Impact factor: 5.505