Nan Zhang1,2, Jiaxing Wang2, Biyue Chen1, Ying Li2, Bing Jiang1,3. 1. Department of Ophthalmology of Second Xiangya Hospital, Central South University, Changsha, China. 2. Department of Ophthalmology, School of Medicine, Emory University, Atlanta, GA, United States. 3. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.
Abstract
Purpose: This meta-analysis aims to investigate the worldwide prevalence of primary angle-closure glaucoma (PACG) and its risk factors in the last 20 years. Methods: We conducted a systematic review and meta-analysis of 37 population-based studies and 144,354 subjects. PubMed, Embase, and Web of Science databases were searched for cross-sectional or cohort studies published in the last 20 years (2000-2020) that reported the prevalence of PACG. The prevalence of PACG was analyzed according to various risk factors. A random-effects model was used for the meta-analysis. Results: The global pooled prevalence of PACG was 0.6% [95% confidence interval (CI) = 0.5-0.8%] for the last 20 years. The prevalence of PACG increases with age. Men are found less likely to have PACG than women (risk ratio = 0.71, 95% CI = 0.53-0.93, p < 0.01). Asia is found to have the highest prevalence of PACG (0.7%, 95% CI = 0.6-1.0%). The current estimated population with PACG is 17.14 million (95% CI = 14.28-22.85) for people older than 40 years old worldwide, with 12.30 million (95% CI = 10.54-17.57) in Asia. It is estimated that by 2050, the global population with PACG will be 26.26 million, with 18.47 million in Asia. Conclusion: PACG affects more than 17 million people worldwide, especially leading a huge burden to Asia. The prevalence of PACG varies widely across different ages, sex, and population geographic variation. Asian, female sex, and age are risk factors of PACG.
Purpose: This meta-analysis aims to investigate the worldwide prevalence of primary angle-closure glaucoma (PACG) and its risk factors in the last 20 years. Methods: We conducted a systematic review and meta-analysis of 37 population-based studies and 144,354 subjects. PubMed, Embase, and Web of Science databases were searched for cross-sectional or cohort studies published in the last 20 years (2000-2020) that reported the prevalence of PACG. The prevalence of PACG was analyzed according to various risk factors. A random-effects model was used for the meta-analysis. Results: The global pooled prevalence of PACG was 0.6% [95% confidence interval (CI) = 0.5-0.8%] for the last 20 years. The prevalence of PACG increases with age. Men are found less likely to have PACG than women (risk ratio = 0.71, 95% CI = 0.53-0.93, p < 0.01). Asia is found to have the highest prevalence of PACG (0.7%, 95% CI = 0.6-1.0%). The current estimated population with PACG is 17.14 million (95% CI = 14.28-22.85) for people older than 40 years old worldwide, with 12.30 million (95% CI = 10.54-17.57) in Asia. It is estimated that by 2050, the global population with PACG will be 26.26 million, with 18.47 million in Asia. Conclusion: PACG affects more than 17 million people worldwide, especially leading a huge burden to Asia. The prevalence of PACG varies widely across different ages, sex, and population geographic variation. Asian, female sex, and age are risk factors of PACG.
Authors: Ryan Eyn Kidd Man; Eva K Fenwick; Jyoti Khadka; ZhiChao Wu; Simon Skalicky; Konrad Pesudovs; Ecosse L Lamoureux Journal: Transl Vis Sci Technol Date: 2022-06-01 Impact factor: 3.048
Authors: Ngozika E Ezinne; Chukwuebuka S Ojukwu; Kingsley K Ekemiri; Obinna F Akano; Edgar Ekure; Uchechukwu Levi Osuagwu Journal: PLoS One Date: 2021-12-02 Impact factor: 3.240