Laura M Holsen1,2,3, Grace Huang3,4, Sara Cherkerzian3,5, Sarah Aroner6, Eric B Loucks7, Steve Buka7, Robert J Handa8,9, Jill M Goldstein1,3,6,10. 1. Division of Women's Health, Department of Medicine, Boston, Massachusetts, USA. 2. Department of Psychiatry, Boston, Massachusetts, USA. 3. Harvard Medical School, Boston, Massachusetts, USA. 4. Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Boston, Massachusetts, USA. 5. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. 6. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. 7. Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA. 8. Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA. 9. Department of Basic Medical Sciences, College of Medicine, University of Arizona, Phoenix, Arizona, USA. 10. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract
Background: Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity appears more common among women. Mechanisms linking these conditions may involve inflammatory and metabolic pathways. The goal of this study was to evaluate the impact of MDD on relationships between OB and cardiometabolic function, and sex differences therein. Materials and Methods: Adult offspring from the New England Family Studies (NEFS) were assessed at ages 39-50, including anthropometry, cardiometabolic profile assays, and metabolic syndrome. Individuals were grouped by body mass index (BMI) and MDD status: healthy weight with (n = 50) or without MDD (n = 95) and obese with (n = 79) or without MDD (n = 131). The interaction of (recurrent) MDD and BMI on cardiometabolic markers was tested using quantile regression models. Results: Participants with MDD exhibited significantly higher hemoglobin A1c (HbA1c) than those without MDD (5.60% vs. 5.35%, p < 0.05). Women with comorbid recurrent MDD and OB had higher HbA1c levels compared to obese women without MDD (5.75% vs. 5.44%, p < 0.05); an interaction between MDD and BMI status was not observed among men. Conclusions: We demonstrated sex differences in the interaction between BMI and recurrent MDD status on a primary biomarker for diabetes risk, suggesting a common metabolic pathway predisposing women to these comorbid conditions. Further investigation is needed to identify mechanisms that may lead to more effective, sex-dependent screening and therapies.
Background: Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity appears more common among women. Mechanisms linking these conditions may involve inflammatory and metabolic pathways. The goal of this study was to evaluate the impact of MDD on relationships between OB and cardiometabolic function, and sex differences therein. Materials and Methods: Adult offspring from the New England Family Studies (NEFS) were assessed at ages 39-50, including anthropometry, cardiometabolic profile assays, and metabolic syndrome. Individuals were grouped by body mass index (BMI) and MDD status: healthy weight with (n = 50) or without MDD (n = 95) and obese with (n = 79) or without MDD (n = 131). The interaction of (recurrent) MDD and BMI on cardiometabolic markers was tested using quantile regression models. Results: Participants with MDD exhibited significantly higher hemoglobin A1c (HbA1c) than those without MDD (5.60% vs. 5.35%, p < 0.05). Women with comorbid recurrent MDD and OB had higher HbA1c levels compared to obese women without MDD (5.75% vs. 5.44%, p < 0.05); an interaction between MDD and BMI status was not observed among men. Conclusions: We demonstrated sex differences in the interaction between BMI and recurrent MDD status on a primary biomarker for diabetes risk, suggesting a common metabolic pathway predisposing women to these comorbid conditions. Further investigation is needed to identify mechanisms that may lead to more effective, sex-dependent screening and therapies.
Authors: David E Kemp; Faramarz Ismail-Beigi; Stephen J Ganocy; Carla Conroy; Keming Gao; Sarah Obral; Elizabeth Fein; Robert L Findling; Joseph R Calabrese Journal: J Affect Disord Date: 2011-07-22 Impact factor: 4.839
Authors: J M Goldstein; S Cherkerzian; S L Buka; G Fitzmaurice; M Hornig; M Gillman; S O'Toole; R P Sloan Journal: J Dev Orig Health Dis Date: 2011-12 Impact factor: 2.401