Literature DB >> 33534112

The Isolation and Manufacture of GMP-Grade Bone Marrow Stromal Cells from Bone Specimens.

Rhayra B Dias1,2, Danielle C Bonfim3.   

Abstract

Bone marrow stromal cells (BMSCs, also known as bone marrow mesenchymal stem cells) are a plastic-adherent heterogeneous cell population that contain inherent skeletal progenitors and a subset of multipotential skeletal stem cells (SSCs). Application of BMSCs in therapeutic protocols implies its isolation and expansion under good manufacturing practices (GMP). Here we describe the procedures we have found to successfully generate practical BMSCs numbers, with preserved biological potency.

Entities:  

Keywords:  Bone marrow stromal cells; Clinical application; GMP-grade; Manufacture

Year:  2021        PMID： 33534112     DOI： 10.1007/7651_2020_319

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  23 in total

1.  "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease.

Authors:  Paolo Bianco; Pamela Gehron Robey; Isabella Saggio; Mara Riminucci
Journal:  Hum Gene Ther       Date:  2010-09       Impact factor: 5.695

2.  Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial.

Authors:  Lingna Deng; Qingxia Peng; Hongxuan Wang; Jingrui Pan; Ying Zhou; Kuang Pan; Jinteng Li; Yanfeng Wu; Yidong Wang
Journal:  Transl Stroke Res       Date:  2018-05-23       Impact factor: 6.829

Review 3.  Advances in stem cell research and therapeutic development.

Authors:  Michele De Luca; Alessandro Aiuti; Giulio Cossu; Malin Parmar; Graziella Pellegrini; Pamela Gehron Robey
Journal:  Nat Cell Biol       Date:  2019-06-17       Impact factor: 28.824

4.  Multilineage potential of adult human mesenchymal stem cells.

Authors:  M F Pittenger; A M Mackay; S C Beck; R K Jaiswal; R Douglas; J D Mosca; M A Moorman; D W Simonetti; S Craig; D R Marshak
Journal:  Science       Date:  1999-04-02       Impact factor: 47.728

5.  Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia.

Authors:  S Keisin Wang; Linden A Green; Natalie A Drucker; Raghu L Motaganahalli; Andres Fajardo; Michael P Murphy
Journal:  J Vasc Surg       Date:  2018-02-01       Impact factor: 4.268

Review 6.  Bone marrow stromal stem cells: nature, biology, and potential applications.

Authors:  P Bianco; M Riminucci; S Gronthos; P G Robey
Journal:  Stem Cells       Date:  2001       Impact factor: 6.277

Review 7.  Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.

Authors:  Li-Tzu Wang; Chiao-Hsuan Ting; Men-Luh Yen; Ko-Jiunn Liu; Huey-Kang Sytwu; Kenneth K Wu; B Linju Yen
Journal:  J Biomed Sci       Date:  2016-11-04       Impact factor: 8.410

8.  A Multicentric, Open-Label, Randomized, Comparative Clinical Trial of Two Different Doses of Expanded hBM-MSCs Plus Biomaterial versus Iliac Crest Autograft, for Bone Healing in Nonunions after Long Bone Fractures: Study Protocol.

Authors:  Enrique Gómez-Barrena; Norma G Padilla-Eguiluz; Cristina Avendaño-Solá; Concepción Payares-Herrera; Ana Velasco-Iglesias; Ferran Torres; Philippe Rosset; Florian Gebhard; Nicola Baldini; Juan C Rubio-Suarez; Eduardo García-Rey; José Cordero-Ampuero; Javier Vaquero-Martin; Francisco Chana; Fernando Marco; Javier García-Coiradas; Pedro Caba-Dessoux; Pablo de la Cuadra; Philippe Hernigou; Charles-Henri Flouzat-Lachaniette; François Gouin; Didier Mainard; Jean Michel Laffosse; Miriam Kalbitz; Ingo Marzi; Norbert Südkamp; Ulrich Stöckle; Gabriela Ciapetti; Davide Maria Donati; Luigi Zagra; Ugo Pazzaglia; Guido Zarattini; Rodolfo Capanna; Fabio Catani
Journal:  Stem Cells Int       Date:  2018-02-22       Impact factor: 5.443

9.  Mesenchymal stem cells.

Authors:  A I Caplan
Journal:  J Orthop Res       Date:  1991-09       Impact factor: 3.494

Review 10.  Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials.

Authors:  Manoj M Lalu; Lauralyn McIntyre; Christina Pugliese; Dean Fergusson; Brent W Winston; John C Marshall; John Granton; Duncan J Stewart
Journal:  PLoS One       Date:  2012-10-25       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.