| Literature DB >> 33533008 |
Yong Song1, Asgerally T Fazleabas2.
Abstract
The endometrium is one of the most dynamic organs in the human body. Until now, cell lines have furthered the understanding of endometrial biology and associated diseases, but they failed to recapitulate the key physiological aspects of the endometrium, especially as it relates to its complex architecture and functions. Organoid culture systems have become an alternative approach to reproduce biological functions of tissues in vitro. Endometrial organoids have now been established from stem/progenitor cells and/or differentiated cells by several methods, which represents a promising tool to gain a deeper understanding of this dynamic organ. In this review, we will discuss the establishment, characteristics, applications, and potential challenges and directions of endometrial organoids.Entities:
Keywords: Endometrial cancer; Endometrial development; Endometrial organoid; Endometriosis; Endometrium; Polycystic ovary syndrome
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Year: 2021 PMID： 33533008 DOI： 10.1007/s43032-021-00471-z
Source DB: PubMed Journal: Reprod Sci ISSN： 1933-7191 Impact factor: 3.060