Yifan Liu1, Tingting Yu2,3, Xiaoqing Li2,3, Dongxue Pan1, Xin Lai1, Yao Chen4, Xiumin Wang4, Xiaodan Yu5, Simao Fu6, Sizhe Huang7, Cuilan Lin8, Shijian Liu9,10. 1. The Second School of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, China. 2. Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4. Department of Endocrine and Genetic Metabolic Diseases, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5. Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6. Zhongshan Hospital of Sun-Yat-Sen University, Zhongshan City, Guangdong Province, China. 7. Health Care Center for Primary and Secondary Schools, Zhongshan City, Guangdong province, China. 8. Bo Ai Hospital of Zhongshan Affiliated to The Second School of Clinical Medicine, Southern Medical University, Zhongshan City, Guangdong Province, China. lincuilan2006@163.com. 9. Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. arrow64@163.com. 10. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. arrow64@163.com.
Abstract
PURPOSE: To investigate the prevalence of precocious puberty in school-based population in Zhongshan, Guangdong, China. METHODS: We recruited a total of 4058 students in grades 1-3 using a multistage stratified cluster random sampling method in a population-based cross-sectional study. We evaluated height, weight, and development of breast and pubic hair in girls, breast development was evaluated by inspection and palpation combined with ultrasound detection for overweight and obese girls, and testicular volume and development of pubic hair in boys. We estimated overall, sex-, age, and district-specific prevalence of precocious puberty and examined the association between prevalence of precocious puberty and body mass index (BMI). RESULTS: The unadjusted and adjusted prevalence of precocious puberty by Tanner stage was 4.74% (girls:8.78%, boys:2.58%) and 6.19% (girls:11.47%, boys:3.26%), respectively. In both urban and suburban areas, the prevalence of precocious puberty was higher in the overweight and obese group than in the normal-weight group (p < 0.05). The prevalence of precocious puberty among overweight (27.94%) and obese (48.00%) girls was higher than that of normal-weight girls (8.73%) (p value for trend < 0.05). In boys, the prevalence of precocious puberty in the obese (6.78%) group was higher than that in the normal-weight (2.86%) group (p < 0.05). CONCLUSIONS: The prevalence of precocious puberty was high in China. Overweight and obesity was related to precocious puberty, but this correlation had gender differences and may be affected by other environmental factors.
PURPOSE: To investigate the prevalence of precocious puberty in school-based population in Zhongshan, Guangdong, China. METHODS: We recruited a total of 4058 students in grades 1-3 using a multistage stratified cluster random sampling method in a population-based cross-sectional study. We evaluated height, weight, and development of breast and pubic hair in girls, breast development was evaluated by inspection and palpation combined with ultrasound detection for overweight and obesegirls, and testicular volume and development of pubic hair in boys. We estimated overall, sex-, age, and district-specific prevalence of precocious puberty and examined the association between prevalence of precocious puberty and body mass index (BMI). RESULTS: The unadjusted and adjusted prevalence of precocious puberty by Tanner stage was 4.74% (girls:8.78%, boys:2.58%) and 6.19% (girls:11.47%, boys:3.26%), respectively. In both urban and suburban areas, the prevalence of precocious puberty was higher in the overweight and obese group than in the normal-weight group (p < 0.05). The prevalence of precocious puberty among overweight (27.94%) and obese (48.00%) girls was higher than that of normal-weight girls (8.73%) (p value for trend < 0.05). In boys, the prevalence of precocious puberty in the obese (6.78%) group was higher than that in the normal-weight (2.86%) group (p < 0.05). CONCLUSIONS: The prevalence of precocious puberty was high in China. Overweight and obesity was related to precocious puberty, but this correlation had gender differences and may be affected by other environmental factors.
Authors: Sara Aghaee; Cecile A Laurent; Julianna Deardorff; Assiamira Ferrara; Louise C Greenspan; Charles P Quesenberry; Lawrence H Kushi; Ai Kubo Journal: Am J Epidemiol Date: 2019-07-01 Impact factor: 4.897
Authors: Soheir S Abou El Ella; Naglaa Fathy Barseem; Maha A Tawfik; Amira F Ahmed Journal: J Pediatr Endocrinol Metab Date: 2020-01-28 Impact factor: 1.634
Authors: Joyce M Lee; Richard Wasserman; Niko Kaciroti; Achamyeleh Gebremariam; Jennifer Steffes; Steven Dowshen; Donna Harris; Janet Serwint; Dianna Abney; Lynn Smitherman; Edward Reiter; Marcia E Herman-Giddens Journal: Pediatrics Date: 2016-01-27 Impact factor: 7.124
Authors: Nis Brix; Andreas Ernst; Lea L B Lauridsen; Onyebuchi A Arah; Ellen A Nohr; Jørn Olsen; Tine Brink Henriksen; Cecilia Høst Ramlau-Hansen Journal: Int J Epidemiol Date: 2019-10-01 Impact factor: 7.196