Mengying Wang1,2, Tao Zhou1, Yongze Song3, Xiang Li1, Hao Ma1, Yonghua Hu2, Yoriko Heianza1, Lu Qi1,4,5. 1. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA. 2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China. 3. School of Design and the Built Environment, Curtin University, Kent Street, Bentley, Perth, Western Australia 6102, Australia. 4. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA. 5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Abstract
AIMS: Little is known about the relation between the long-term joint exposure to various ambient air pollutants and the incidence of heart failure (HF). We aimed to assess the joint association of various air pollutants with HF risk and examine the modification effect of the genetic susceptibility. METHODS AND RESULTS: This study included 432 530 participants free of HF, atrial fibrillation, or coronary heart disease in the UK Biobank study. All participants were enrolled from 2006 to 2010 and followed up to 2018. The information on particulate matter (PM) with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), and between 2.5 and 10 µm (PM2.5-10) as well as nitrogen oxides (NO2 and NOx) was collected. We newly proposed an air pollution score to assess the joint exposure to the five air pollutants through summing each pollutant concentration weighted by the regression coefficients with HF from single-pollutant models. We also calculated the weighted genetic risk score of HF. During a median of 10.1 years (4 346 642 person-years) of follow-up, we documented 4201 incident HF. The hazard ratios (HRs) [95% confidence interval (CI)] of HF for a 10 µg/m3 increase in PM2.5, PM10, PM2.5-10, NO2, and NOx were 1.85 (1.34-2.55), 1.61 (1.30-2.00), 1.13 (0.80-1.59), 1.10 (1.04-1.15), and 1.04 (1.02-1.06), respectively. We found that the air pollution score was associated with an increased risk of incident HF in a dose-response fashion. The HRs (95% CI) of HF were 1.16 (1.05-1.28), 1.19 (1.08-1.32), 1.21 (1.09-1.35), and 1.31 (1.17-1.48) in higher quintile groups compared with the lowest quintile of the air pollution score (P trend <0.001). In addition, we observed that the elevated risk of HF associated with a higher air pollution score was strengthened by the genetic susceptibility to HF. CONCLUSION: Our results indicate that the long-term joint exposure to various air pollutants including PM2.5, PM10, PM2.5-10, NO2, and NOx is associated with an elevated risk of incident HF in an additive manner. Our findings highlight the importance to comprehensively assess various air pollutants in relation to the HF risk. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Little is known about the relation between the long-term joint exposure to various ambient air pollutants and the incidence of heart failure (HF). We aimed to assess the joint association of various air pollutants with HF risk and examine the modification effect of the genetic susceptibility. METHODS AND RESULTS: This study included 432 530 participants free of HF, atrial fibrillation, or coronary heart disease in the UK Biobank study. All participants were enrolled from 2006 to 2010 and followed up to 2018. The information on particulate matter (PM) with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), and between 2.5 and 10 µm (PM2.5-10) as well as nitrogen oxides (NO2 and NOx) was collected. We newly proposed an air pollution score to assess the joint exposure to the five air pollutants through summing each pollutant concentration weighted by the regression coefficients with HF from single-pollutant models. We also calculated the weighted genetic risk score of HF. During a median of 10.1 years (4 346 642 person-years) of follow-up, we documented 4201 incident HF. The hazard ratios (HRs) [95% confidence interval (CI)] of HF for a 10 µg/m3 increase in PM2.5, PM10, PM2.5-10, NO2, and NOx were 1.85 (1.34-2.55), 1.61 (1.30-2.00), 1.13 (0.80-1.59), 1.10 (1.04-1.15), and 1.04 (1.02-1.06), respectively. We found that the air pollution score was associated with an increased risk of incident HF in a dose-response fashion. The HRs (95% CI) of HF were 1.16 (1.05-1.28), 1.19 (1.08-1.32), 1.21 (1.09-1.35), and 1.31 (1.17-1.48) in higher quintile groups compared with the lowest quintile of the air pollution score (P trend <0.001). In addition, we observed that the elevated risk of HF associated with a higher air pollution score was strengthened by the genetic susceptibility to HF. CONCLUSION: Our results indicate that the long-term joint exposure to various air pollutants including PM2.5, PM10, PM2.5-10, NO2, and NOx is associated with an elevated risk of incident HF in an additive manner. Our findings highlight the importance to comprehensively assess various air pollutants in relation to the HF risk. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Loren E Wold; Zhekang Ying; Kirk R Hutchinson; Markus Velten; Matthew W Gorr; Christina Velten; Dane J Youtz; Aixia Wang; Pamela A Lucchesi; Qinghua Sun; Sanjay Rajagopalan Journal: Circ Heart Fail Date: 2012-06-01 Impact factor: 8.790
Authors: David M Stieb; Richard T Burnett; Marc Smith-Doiron; Orly Brion; Hwashin Hyun Shin; Vanita Economou Journal: J Air Waste Manag Assoc Date: 2008-03 Impact factor: 2.235
Authors: Marloes Eeftens; Rob Beelen; Kees de Hoogh; Tom Bellander; Giulia Cesaroni; Marta Cirach; Christophe Declercq; Audrius Dėdelė; Evi Dons; Audrey de Nazelle; Konstantina Dimakopoulou; Kirsten Eriksen; Grégoire Falq; Paul Fischer; Claudia Galassi; Regina Gražulevičienė; Joachim Heinrich; Barbara Hoffmann; Michael Jerrett; Dirk Keidel; Michal Korek; Timo Lanki; Sarah Lindley; Christian Madsen; Anna Mölter; Gizella Nádor; Mark Nieuwenhuijsen; Michael Nonnemacher; Xanthi Pedeli; Ole Raaschou-Nielsen; Evridiki Patelarou; Ulrich Quass; Andrea Ranzi; Christian Schindler; Morgane Stempfelet; Euripides Stephanou; Dorothea Sugiri; Ming-Yi Tsai; Tarja Yli-Tuomi; Mihály J Varró; Danielle Vienneau; Stephanie von Klot; Kathrin Wolf; Bert Brunekreef; Gerard Hoek Journal: Environ Sci Technol Date: 2012-10-01 Impact factor: 9.028
Authors: Aaron J Cohen; Michael Brauer; Richard Burnett; H Ross Anderson; Joseph Frostad; Kara Estep; Kalpana Balakrishnan; Bert Brunekreef; Lalit Dandona; Rakhi Dandona; Valery Feigin; Greg Freedman; Bryan Hubbell; Amelia Jobling; Haidong Kan; Luke Knibbs; Yang Liu; Randall Martin; Lidia Morawska; C Arden Pope; Hwashin Shin; Kurt Straif; Gavin Shaddick; Matthew Thomas; Rita van Dingenen; Aaron van Donkelaar; Theo Vos; Christopher J L Murray; Mohammad H Forouzanfar Journal: Lancet Date: 2017-04-10 Impact factor: 79.321