Literature DB >> 33527127

Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy.

Emmanouil Papasavvas1, Livio Azzoni1, Brian N Ross1, Matthew Fair1, Zhe Yuan1, Kwasi Gyampoh1, Agnieszka Mackiewicz1, Amanda C Sciorillo1, Amelie Pagliuzza2, Steven M Lada3, Guoxin Wu4, Shih Lin Goh4, Carolyn Bahnck-Teets4, Daniel J Holder4, Paul D Zuck4, Mohammad Damra1, Kenneth M Lynn5, Pablo Tebas6, Karam Mounzer7, Jay R Kostman8, Mohamed Abdel-Mohsen1, Douglas Richman3, Nicolas Chomont2, Bonnie J Howell4, Luis J Montaner1.   

Abstract

Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  HIV latency; IPDA; TILDA; integrated HIV; p24

Mesh：

Substances：

Year:  2021        PMID： 33527127      PMCID： PMC7850524          DOI： 10.1093/cid/ciaa809

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   20.999


  12 in total

1.  Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR.

Authors:  Steven M Lada; Karissa Huang; D Jake VanBelzen; Luis J Montaner; Una O'Doherty; Douglas D Richman
Journal:  J Clin Microbiol       Date:  2018-11-27       Impact factor: 5.948

2.  HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.

Authors:  Guoxin Wu; Michael Swanson; Aarthi Talla; Donald Graham; Julie Strizki; Daniel Gorman; Richard Jo Barnard; Wade Blair; Ole S Søgaard; Martin Tolstrup; Lars Østergaard; Thomas A Rasmussen; Rafick-Pierre Sekaly; Nancie M Archin; David M Margolis; Daria J Hazuda; Bonnie J Howell
Journal:  JCI Insight       Date:  2017-08-17

3.  Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.

Authors:  D Finzi; M Hermankova; T Pierson; L M Carruth; C Buck; R E Chaisson; T C Quinn; K Chadwick; J Margolick; R Brookmeyer; J Gallant; M Markowitz; D D Ho; D D Richman; R F Siliciano
Journal:  Science       Date:  1997-11-14       Impact factor: 47.728

4.  Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.

Authors:  Angela M Mexas; Erin H Graf; Matthew J Pace; Jianqing J Yu; Emmanouil Papasavvas; Livio Azzoni; Michael P Busch; Michele Di Mascio; Andrea S Foulkes; Stephen A Migueles; Luis J Montaner; Una O'Doherty
Journal:  AIDS       Date:  2012-11-28       Impact factor: 4.177

5.  Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.

Authors:  J K Wong; M Hezareh; H F Günthard; D V Havlir; C C Ignacio; C A Spina; D D Richman
Journal:  Science       Date:  1997-11-14       Impact factor: 47.728

6.  Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.

Authors:  Amy E Baxter; Julia Niessl; Rémi Fromentin; Jonathan Richard; Filippos Porichis; Roxanne Charlebois; Marta Massanella; Nathalie Brassard; Nirmin Alsahafi; Gloria-Gabrielle Delgado; Jean-Pierre Routy; Bruce D Walker; Andrés Finzi; Nicolas Chomont; Daniel E Kaufmann
Journal:  Cell Host Microbe       Date:  2016-08-18       Impact factor: 21.023

7.  A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.

Authors:  Francesco Andrea Procopio; Rémi Fromentin; Deanna A Kulpa; Jessica H Brehm; Anne-Gaelle Bebin; Matthew C Strain; Douglas D Richman; Una O'Doherty; Sarah Palmer; Frederick M Hecht; Rebecca Hoh; Richard J O Barnard; Michael D Miller; Daria J Hazuda; Steven G Deeks; Rafick-Pierre Sékaly; Nicolas Chomont
Journal:  EBioMedicine       Date:  2015-06-27       Impact factor: 8.143

8.  Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.

Authors:  Susanne Eriksson; Erin H Graf; Viktor Dahl; Matthew C Strain; Steven A Yukl; Elena S Lysenko; Ronald J Bosch; Jun Lai; Stanley Chioma; Fatemeh Emad; Mohamed Abdel-Mohsen; Rebecca Hoh; Frederick Hecht; Peter Hunt; Ma Somsouk; Joseph Wong; Rowena Johnston; Robert F Siliciano; Douglas D Richman; Una O'Doherty; Sarah Palmer; Steven G Deeks; Janet D Siliciano
Journal:  PLoS Pathog       Date:  2013-02-14       Impact factor: 6.823

9.  A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.

Authors:  Katherine M Bruner; Zheng Wang; Francesco R Simonetti; Alexandra M Bender; Kyungyoon J Kwon; Srona Sengupta; Emily J Fray; Subul A Beg; Annukka A R Antar; Katharine M Jenike; Lynn N Bertagnolli; Adam A Capoferri; Joshua T Kufera; Andrew Timmons; Christopher Nobles; John Gregg; Nikolas Wada; Ya-Chi Ho; Hao Zhang; Joseph B Margolick; Joel N Blankson; Steven G Deeks; Frederic D Bushman; Janet D Siliciano; Gregory M Laird; Robert F Siliciano
Journal:  Nature       Date:  2019-01-30       Impact factor: 49.962

10.  Defective proviruses rapidly accumulate during acute HIV-1 infection.

Authors:  Katherine M Bruner; Alexandra J Murray; Ross A Pollack; Mary G Soliman; Sarah B Laskey; Adam A Capoferri; Jun Lai; Matthew C Strain; Steven M Lada; Rebecca Hoh; Ya-Chi Ho; Douglas D Richman; Steven G Deeks; Janet D Siliciano; Robert F Siliciano
Journal:  Nat Med       Date:  2016-08-08       Impact factor: 53.440
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  10 in total

1.  Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA.

Authors:  Francesco R Simonetti; Jennifer A White; Camille Tumiotto; Kristen D Ritter; Mian Cai; Rajesh T Gandhi; Steven G Deeks; Bonnie J Howell; Luis J Montaner; Joel N Blankson; Albine Martin; Gregory M Laird; Robert F Siliciano; John W Mellors; Janet D Siliciano
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-20       Impact factor: 11.205

2.  Measuring the Haystack's Needles.

Authors:  David M Margolis
Journal:  J Infect Dis       Date:  2021-02-03       Impact factor: 5.226

3.  Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART.

Authors:  Catherine R Cochrane; Thomas A Angelovich; Michael Roche; Melissa J Churchill; Sarah J Byrnes; Emily Waring; Aleks C Guanizo; Gemma S Trollope; Jingling Zhou; Judith Vue; Lachlan Senior; Emma Wanicek; Janna Jamal Eddine; Matthew J Gartner; Trisha A Jenkins; Paul R Gorry; Bruce J Brew; Sharon R Lewin; Jacob D Estes
Journal:  Ann Neurol       Date:  2022-08-09       Impact factor: 11.274

4.  High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood.

Authors:  Stefan Petkov; Yonas Bekele; Tadepally Lakshmikanth; Bo Hejdeman; Maurizio Zazzi; Petter Brodin; Francesca Chiodi
Journal:  Sci Rep       Date:  2020-11-24       Impact factor: 4.379

5.  Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.

Authors:  Chenjie Wan; Nadine Bachmann; Venelin Mitov; François Blanquart; Susana Posada Céspedes; Teja Turk; Kathrin Neumann; Niko Beerenwinkel; Jasmina Bogojeska; Jacques Fellay; Volker Roth; Jürg Böni; Matthieu Perreau; Thomas Klimkait; Sabine Yerly; Manuel Battegay; Laura Walti; Alexandra Calmy; Pietro Vernazza; Enos Bernasconi; Matthias Cavassini; Karin J Metzner; Huldrych F Günthard; Roger D Kouyos
Journal:  Nat Commun       Date:  2020-11-02       Impact factor: 14.919

6.  HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).

Authors:  Natalie N Kinloch; Yanqin Ren; Winiffer D Conce Alberto; Winnie Dong; Pragya Khadka; Szu Han Huang; Talia M Mota; Andrew Wilson; Aniqa Shahid; Don Kirkby; Marianne Harris; Colin Kovacs; Erika Benko; Mario A Ostrowski; Perla M Del Rio Estrada; Avery Wimpelberg; Christopher Cannon; W David Hardy; Lynsay MacLaren; Harris Goldstein; Chanson J Brumme; Guinevere Q Lee; Rebecca M Lynch; Zabrina L Brumme; R Brad Jones
Journal:  Nat Commun       Date:  2021-01-08       Impact factor: 14.919

7.  Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.

Authors:  Justin Harper; Susan P Ribeiro; Chi Ngai Chan; Malika Aid; Claire Deleage; Luca Micci; Maria Pino; Barbara Cervasi; Gopalan Raghunathan; Eric Rimmer; Gulesi Ayanoglu; Guoxin Wu; Neeta Shenvi; Richard Jo Barnard; Gregory Q Del Prete; Kathleen Busman-Sahay; Guido Silvestri; Deanna A Kulpa; Steven E Bosinger; Kirk A Easley; Bonnie J Howell; Dan Gorman; Daria J Hazuda; Jacob D Estes; Rafick-Pierre Sekaly; Mirko Paiardini
Journal:  J Clin Invest       Date:  2022-04-15       Impact factor: 19.456

8.  Persistence of Unintegrated HIV DNA Associates With Ongoing NK Cell Activation and CD34+DNAM-1brightCXCR4+ Precursor Turnover in Vertically Infected Patients Despite Successful Antiretroviral Treatment.

Authors:  Lucia Taramasso; Federica Bozzano; Anna Casabianca; Chiara Orlandi; Francesca Bovis; Sara Mora; Mauro Giacomini; Lorenzo Moretta; Mauro Magnani; Antonio Di Biagio; Andrea De Maria
Journal:  Front Immunol       Date:  2022-04-26       Impact factor: 8.786

9.  VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies.

Authors:  Maria C Puertas; Ángel Bayón-Gil; Maria C Garcia-Guerrero; Maria Salgado; Víctor Urrea; Sara Morón-López; Ruth Peña; Esther Jiménez-Moyano; Bonaventura Clotet; Julia G Prado; Javier Martinez-Picado
Journal:  mBio       Date:  2021-06-22       Impact factor: 7.867

10.  Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA.

Authors:  Christian Gaebler; Shane D Falcinelli; Elina Stoffel; Jenna Read; Ross Murtagh; Thiago Y Oliveira; Victor Ramos; Julio C C Lorenzi; Jennifer Kirchherr; Katherine S James; Brigitte Allard; Caroline Baker; JoAnn D Kuruc; Marina Caskey; Nancie M Archin; Robert F Siliciano; David M Margolis; Michel C Nussenzweig
Journal:  J Virol       Date:  2021-02-24       Impact factor: 5.103
  10 in total

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