Literature DB >> 33526483

Multidrug-Resistant Plasmodium falciparum Parasites in the Central Highlands of Vietnam Jeopardize Malaria Control and Elimination Strategies.

Huynh Hong Quang1, Marina Chavchich2, Nguyen Thi Minh Trinh1, Kimberly A Edgel3, Michael D Edstein4, Nicholas J Martin3.   

Abstract

Plasmodium falciparum resistance to dihydroartemisinin-piperaquine has spread through the Greater Mekong Subregion to southwestern Vietnam. In 2018 to 2019, we collected 127 P. falciparum isolates from Dak Nong (36), Dak Lak (55), Gia Lai (13), and Kon Tum (23) provinces in Vietnam's Central Highlands and found parasites bearing the Pfkelch13 C580Y mutation and multiple plasmepsin 2/3 genes (mean prevalence, 17.9%; range, 4.3% to 27.8%), conferring resistance to dihydroartemisinin-piperaquine. This information is important for drug policy decisions in Vietnam.

Entities:  

Keywords:  Pfcrt; Pfkelch13; Vietnam; dihydroartemisinin; falciparum malaria; piperaquine; plasmepsin 2/3; pyronaridine resistance

Year:  2021        PMID： 33526483      PMCID： PMC8097446          DOI： 10.1128/AAC.01639-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  36 in total

1.  Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

Authors:  Marina Chavchich; Lucia Gerena; Jennifer Peters; Nanhua Chen; Qin Cheng; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

2.  Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.

Authors:  Ric N Price; Anne-Catrin Uhlemann; Michele van Vugt; Al Brockman; Robert Hutagalung; Shalini Nair; Denae Nash; Pratap Singhasivanon; Tim J C Anderson; Sanjeev Krishna; Nicholas J White; François Nosten
Journal:  Clin Infect Dis       Date:  2006-04-26       Impact factor: 9.079

3.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

Review 4.  Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance.

Authors:  Toshihiro Mita; Kazuyuki Tanabe
Journal:  Jpn J Infect Dis       Date:  2012       Impact factor: 1.362

5.  Pyronaridine-artesunate Efficacy and Safety in Uncomplicated Plasmodium falciparum Malaria in Areas of Artemisinin-resistant Falciparum in Viet Nam (2017-2018).

Authors:  Phuc Quang Bui; Quang Hong Huynh; Duong Thanh Tran; Dong Thanh Le; Thieu Quang Nguyen; Hanh Van Truong; Nimol Khim; Benoit Witkowski; Dai Cong Tran; Maria Dorina Bustos; Pascal Ringwald; Tinh Thi Ta
Journal:  Clin Infect Dis       Date:  2020-05-06       Impact factor: 9.079

6.  Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study.

Authors:  Roberto Amato; Pharath Lim; Olivo Miotto; Chanaki Amaratunga; Dalin Dek; Richard D Pearson; Jacob Almagro-Garcia; Aaron T Neal; Sokunthea Sreng; Seila Suon; Eleanor Drury; Dushyanth Jyothi; Jim Stalker; Dominic P Kwiatkowski; Rick M Fairhurst
Journal:  Lancet Infect Dis       Date:  2016-11-03       Impact factor: 25.071

7.  The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study.

Authors:  Mallika Imwong; Kanokon Suwannasin; Chanon Kunasol; Kreepol Sutawong; Mayfong Mayxay; Huy Rekol; Frank M Smithuis; Tin Maung Hlaing; Kyaw M Tun; Rob W van der Pluijm; Rupam Tripura; Olivo Miotto; Didier Menard; Mehul Dhorda; Nicholas P J Day; Nicholas J White; Arjen M Dondorp
Journal:  Lancet Infect Dis       Date:  2017-02-02       Impact factor: 25.071

8.  Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.

Authors:  Shannon Takala-Harrison; Taane G Clark; Christopher G Jacob; Michael P Cummings; Olivo Miotto; Arjen M Dondorp; Mark M Fukuda; Francois Nosten; Harald Noedl; Mallika Imwong; Delia Bethell; Youry Se; Chanthap Lon; Stuart D Tyner; David L Saunders; Duong Socheat; Frederic Ariey; Aung Pyae Phyo; Peter Starzengruber; Hans-Peter Fuehrer; Paul Swoboda; Kasia Stepniewska; Jennifer Flegg; Cesar Arze; Gustavo C Cerqueira; Joana C Silva; Stacy M Ricklefs; Stephen F Porcella; Robert M Stephens; Matthew Adams; Leo J Kenefic; Susana Campino; Sarah Auburn; Bronwyn MacInnis; Dominic P Kwiatkowski; Xin-zhuan Su; Nicholas J White; Pascal Ringwald; Christopher V Plowe
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205

Review 9.  The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread.

Authors:  Charles J Woodrow; Nicholas J White
Journal:  FEMS Microbiol Rev       Date:  2016-09-08       Impact factor: 16.408

10.  Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study.

Authors:  Roberto Amato; Richard D Pearson; Jacob Almagro-Garcia; Chanaki Amaratunga; Pharath Lim; Seila Suon; Sokunthea Sreng; Eleanor Drury; Jim Stalker; Olivo Miotto; Rick M Fairhurst; Dominic P Kwiatkowski
Journal:  Lancet Infect Dis       Date:  2018-02-02       Impact factor: 71.421
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  1 in total

1.  A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility.

Authors:  Nonlawat Boonyalai; Kirakarn Kirativanich; Chatchadaporn Thamnurak; Chantida Praditpol; Brian A Vesely; Mariusz Wojnarski; John S Griesenbeck; Norman C Waters
Journal:  Malar J       Date:  2022-04-22       Impact factor: 3.469
  1 in total

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