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Literature DB >> 33522833

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca²⁺ Leak.

Ting Liu¹, Ni Yang¹, Agnieszka Sidor¹, Brian O'Rourke¹.

Abstract

[Figure: see text].

Entities: Chemical

Keywords: genetic therapy; guinea pigs; heart failure; reactive oxygen species; ryanodine receptor calcium release channel; sudden cardiac death

Mesh：

Substances：

Year: 2021 PMID： 33522833 PMCID： PMC8049980 DOI： 10.1161/CIRCRESAHA.120.318562

Source DB: PubMed Journal: Circ Res ISSN： 0009-7330 Impact factor: 17.367

53 in total

1. Quantitative assessment of the SR Ca2+ leak-load relationship.

Authors: Thomas R Shannon; Kenneth S Ginsburg; Donald M Bers
Journal: Circ Res Date: 2002-10-04 Impact factor: 17.367

2. Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure.

Authors: M Lindner; E Erdmann; D J Beuckelmann
Journal: J Mol Cell Cardiol Date: 1998-04 Impact factor: 5.000

3. Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes.

Authors: Michael Kohlhaas; Ting Liu; Andreas Knopp; Tanja Zeller; Mei Fang Ong; Michael Böhm; Brian O'Rourke; Christoph Maack
Journal: Circulation Date: 2010-03-29 Impact factor: 29.690

Review 4. Mitochondrial dysfunction in pathophysiology of heart failure.

Authors: Bo Zhou; Rong Tian
Journal: J Clin Invest Date: 2018-08-20 Impact factor: 14.808

5. Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts.

Authors: Leroy L Cooper; Weiyan Li; Yichun Lu; Jason Centracchio; Radmila Terentyeva; Gideon Koren; Dmitry Terentyev
Journal: J Physiol Date: 2013-09-16 Impact factor: 5.182

Review 6. Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart.

Authors: Ting Liu; Brian O'Rourke
Journal: J Bioenerg Biomembr Date: 2009-04 Impact factor: 2.945

7. Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria.

Authors: S Kettlewell; P Cabrero; S A Nicklin; J A T Dow; S Davies; G L Smith
Journal: J Mol Cell Cardiol Date: 2009-02-26 Impact factor: 5.000

8. Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure.

Authors: Swati Dey; Deeptankar DeMazumder; Agnieszka Sidor; D Brian Foster; Brian O'Rourke
Journal: Circ Res Date: 2018-06-13 Impact factor: 17.367

9. Mitochondrial Ca²⁺ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy.

Authors: An Xie; Zhen Song; Hong Liu; Anyu Zhou; Guangbin Shi; Qiongying Wang; Lianzhi Gu; Man Liu; Lai-Hua Xie; Zhilin Qu; Samuel C Dudley
Journal: J Am Heart Assoc Date: 2018-04-07 Impact factor: 5.501

10. Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies.

Authors: Markus B Sikkel; Darrel P Francis; James Howard; Fabiana Gordon; Christina Rowlands; Nicholas S Peters; Alexander R Lyon; Sian E Harding; Kenneth T MacLeod
Journal: Cardiovasc Res Date: 2017-12-01 Impact factor: 10.787

12 in total

1. Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling.

Authors: Pei Wang; Shangcheng Xu; Jiqian Xu; Yanguo Xin; Yan Lu; Huiliang Zhang; Bo Zhou; Haodong Xu; Shey-Shing Sheu; Rong Tian; Wang Wang
Journal: Circulation Date: 2022-02-15 Impact factor: 29.690

2. MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca²⁺ release in hypertrophic rat cardiomyocytes.

Authors: Shanna Hamilton; Radmila Terentyeva; Fruzsina Perger; Benjamín Hernández Orengo; Benjamin Martin; Matthew W Gorr; Andriy E Belevych; Richard T Clements; Sandor Györke; Dmitry Terentyev
Journal: Am J Physiol Heart Circ Physiol Date: 2021-08-20 Impact factor: 5.125

3. Enhanced NCLX-dependent mitochondrial Ca²⁺ efflux attenuates pathological remodeling in heart failure.

Authors: Joanne F Garbincius; Timothy S Luongo; Pooja Jadiya; Alycia N Hildebrand; Devin W Kolmetzky; Adam S Mangold; Rajika Roy; Jessica Ibetti; Mary Nwokedi; Walter J Koch; John W Elrod
Journal: J Mol Cell Cardiol Date: 2022-03-28 Impact factor: 5.763

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca²⁺ Leak.

1. Quantitative assessment of the SR Ca2+ leak-load relationship.

2. Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure.

3. Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes.

Review 4. Mitochondrial dysfunction in pathophysiology of heart failure.

5. Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts.

Review 6. Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart.

7. Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria.

8. Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure.

9. Mitochondrial Ca²⁺ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy.

10. Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies.

1. Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling.

2. MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca²⁺ release in hypertrophic rat cardiomyocytes.

3. Enhanced NCLX-dependent mitochondrial Ca²⁺ efflux attenuates pathological remodeling in heart failure.

Review 4. VDAC2 as a novel target for heart failure: Ca²⁺ at the sarcomere, mitochondria and SR.

Review 5. Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.

6. Is the Failing Heart Starved of Mitochondrial Calcium?

7. Mitochondria in Pathological Cardiac Remodeling.

Review 8. Mitochondrial calcium exchange in physiology and disease.

9. PDE1 Inhibition Modulates Ca_v1.2 Channel to Stimulate Cardiomyocyte Contraction.

10. Cardiomyocyte Na⁺ and Ca²⁺ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors.

Review 4. Mitochondrial dysfunction in pathophysiology of heart failure.

Review 6. Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart.

Review 4. VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR.

Review 5. Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.

Review 8. Mitochondrial calcium exchange in physiology and disease.

Review 4. VDAC2 as a novel target for heart failure: Ca²⁺ at the sarcomere, mitochondria and SR.