Amaia Bilbao1,2,3, Jesús Martín-Fernández2,4,5, Lidia García-Pérez2,6, José Ignacio Mendezona7, Marta Arrasate7,8, Ruth Candela9, Francisco Javier Acosta2,10,11, Soraya Estebanez1, Ander Retolaza2,12,13. 1. Osakidetza Basque Health Service, Basurto University Hospital, Research Unit, Bilbao, Spain. 2. Health Service Research Network on Chronic Diseases (REDISSEC), Spain. 3. Kronikgune Institute for Health Services Research, Barakaldo, Spain. 4. Oeste Multiprofessional Teaching Unit of Primary and Community Care, Primary Healthcare Management, Madrid Health Service, Madrid, Spain. 5. Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain. 6. Fundación Canaria de Investigación Sanitaria (FUNCANIS), Santa Cruz de Tenerife, Spain. 7. Osakidetza Basque Health Service, Bizkaia Mental Health Network, Derio Mental Health Centre, Derio, Spain. 8. Osakidetza Basque Health Service, Bizkaia Mental Health Network, Uribe Mental Health Centre, Getxo, Spain. 9. Psychiatry Department, Fuenlabrada University Hospital, Madrid, Spain. 10. Service of Mental Health, General Management of Healthcare Programs, Canary Islands Health Service, Canary Islands, Spain. 11. Insular University Hospital of Gran Canaria, Canary Islands, Spain. 12. Osakidetza Basque Health Service, Bizkaia Mental Health Network, Basauri Mental Health Centre, Basauri, Spain. 13. Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Abstract
BACKGROUND: The EQ-5D is one of the most recommended questionnaires for cost-effectiveness studies. AIMS: To study the psychometric properties of the EQ-5D-5L in patients with major depression. METHODS: This prospective observational study included 433 patients with major depression who completed the EQ-5D-5L and Patient Health Questionnaire-9 (PHQ-9) questionnaires at baseline, of whom 310 also did six months later. The structural validity was assessed by confirmatory factor analysis, the item functioning by item response analysis, and reliability by Cronbach's alpha. Convergent validity and known-groups validity was studied using the PHQ-9 and a general health question. To assess responsiveness effect sizes were calculated. RESULTS: The results supported the unidimensionality and showed adequate item functioning, with somewhat age-related item differential functioning for the mobility dimension. Cronbach's alpha was 0.77. The EQ-5D-5L showed a high correlation with the PHQ-9 and general health. The more severe the depression level and the poorer the general health, the lower the EQ-5D-5L scores (p < 0.001). Responsiveness parameters showed moderate changes among "improved" patients. CONCLUSIONS: These findings support the adequate psychometric properties of the EQ-5D-5L in patients with major depression. It could be very useful for clinicians and researchers as an outcome measure and for use in economic evaluation.
BACKGROUND: The EQ-5D is one of the most recommended questionnaires for cost-effectiveness studies. AIMS: To study the psychometric properties of the EQ-5D-5L in patients with major depression. METHODS: This prospective observational study included 433 patients with major depression who completed the EQ-5D-5L and Patient Health Questionnaire-9 (PHQ-9) questionnaires at baseline, of whom 310 also did six months later. The structural validity was assessed by confirmatory factor analysis, the item functioning by item response analysis, and reliability by Cronbach's alpha. Convergent validity and known-groups validity was studied using the PHQ-9 and a general health question. To assess responsiveness effect sizes were calculated. RESULTS: The results supported the unidimensionality and showed adequate item functioning, with somewhat age-related item differential functioning for the mobility dimension. Cronbach's alpha was 0.77. The EQ-5D-5L showed a high correlation with the PHQ-9 and general health. The more severe the depression level and the poorer the general health, the lower the EQ-5D-5L scores (p < 0.001). Responsiveness parameters showed moderate changes among "improved" patients. CONCLUSIONS: These findings support the adequate psychometric properties of the EQ-5D-5L in patients with major depression. It could be very useful for clinicians and researchers as an outcome measure and for use in economic evaluation.
Authors: Sebastian Wolf; Britta Seiffer; Johanna-Marie Zeibig; Jana Welkerling; Leonie Louisa Bauer; Anna Katharina Frei; Thomas Studnitz; Stephanie Rosenstiel; David Victor Fiedler; Florian Helmhold; Andreas Ray; Eva Herzog; Keisuke Takano; Tristan Nakagawa; Saskia Kropp; Sebastian Franke; Stefan Peters; Nadja El-Kurd; Lena Zwanzleitner; Leonie Sundmacher; Ander Ramos-Murguialday; Martin Hautzinger; Gorden Sudeck; Thomas Ehring Journal: BMC Psychiatry Date: 2021-10-30 Impact factor: 3.630
Authors: Julia A Sabet; Moa S Ekman; A Sofia Lundvall; Ulf Risérus; Ulrica Johansson; Åsa Öström; Viola Adamsson; Yang Cao; Mussie Msghina; Robert J Brummer Journal: Nutrients Date: 2021-03-10 Impact factor: 5.717