Literature DB >> 33513786

Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier.

Yelixza I Avila1, Morgan Chandler1, Edward Cedrone2, Hannah S Newton2, Melina Richardson1, Jie Xu2, Jeffrey D Clogston2, Neill J Liptrott3, Kirill A Afonin1, Marina A Dobrovolskaia2.   

Abstract

Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.

Entities:  

Keywords:  NANPs; cytokines; immunology; immunotherapies; nucleic acid nanoparticles; vaccines

Mesh：

Substances：

Year:  2021        PMID： 33513786      PMCID： PMC7865455          DOI： 10.3390/molecules26030652

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  63 in total

1.  PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy.

Authors:  Fereydoon Abedi-Gaballu; Gholamreza Dehghan; Maryam Ghaffari; Reza Yekta; Soheil Abbaspour-Ravasjani; Behzad Baradaran; Jafar Ezzati Nazhad Dolatabadi; Michael R Hamblin
Journal:  Appl Mater Today       Date:  2018-05-29

2.  Intra-individual variability over time in serum cytokine levels among participants in the prostate, lung, colorectal, and ovarian cancer screening Trial.

Authors:  Jonathan N Hofmann; Kai Yu; Rachel K Bagni; Qing Lan; Nathaniel Rothman; Mark P Purdue
Journal:  Cytokine       Date:  2011-07-20       Impact factor: 3.861

3.  Polyamidoamine dendrimers as gene delivery carriers in the inner ear: How to improve transfection efficiency.

Authors:  Hui Wang; Hai-Bo Shi; Shan-Kai Yin
Journal:  Exp Ther Med       Date:  2011-06-27       Impact factor: 2.447

Review 4.  Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions.

Authors:  Christine Grimaldi; Deborah Finco; Madeline M Fort; Daniel Gliddon; Kirsty Harper; Whitney S Helms; Jane A Mitchell; Raegan O'Lone; Stanley T Parish; Marie-Soleil Piche; Daniel M Reed; Gabriele Reichmann; Patricia C Ryan; Richard Stebbings; Mindi Walker
Journal:  Cytokine       Date:  2016-06-13       Impact factor: 3.861

5.  Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrations.

Authors:  Thommey P Thomas; Istvan Majoros; Alina Kotlyar; Douglas Mullen; Mark M Banaszak Holl; James R Baker
Journal:  Biomacromolecules       Date:  2009-12-14       Impact factor: 6.988

6.  DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy.

Authors:  Yang Du; Qiao Jiang; Nicolas Beziere; Linlin Song; Qian Zhang; Dong Peng; Chongwei Chi; Xin Yang; Hongbo Guo; Gaël Diot; Vasilis Ntziachristos; Baoquan Ding; Jie Tian
Journal:  Adv Mater       Date:  2016-09-28       Impact factor: 30.849

7.  Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells.

Authors:  Enping Hong; Justin R Halman; Ankit Shah; Edward Cedrone; Nguyen Truong; Kirill A Afonin; Marina A Dobrovolskaia
Journal:  Molecules       Date:  2019-03-20       Impact factor: 4.411

Review 8.  Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior.

Authors:  Morgan Chandler; Kirill A Afonin
Journal:  Nanomaterials (Basel)       Date:  2019-04-12       Impact factor: 5.076

9.  RNA-DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells.

Authors:  Weina Ke; Enping Hong; Renata F Saito; Maria Cristina Rangel; Jian Wang; Mathias Viard; Melina Richardson; Emil F Khisamutdinov; Martin Panigaj; Nikolay V Dokholyan; Roger Chammas; Marina A Dobrovolskaia; Kirill A Afonin
Journal:  Nucleic Acids Res       Date:  2019-02-20       Impact factor: 16.971

10.  Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles.

Authors:  Emil F Khisamutdinov; Hui Li; Daniel L Jasinski; Jiao Chen; Jian Fu; Peixuan Guo
Journal:  Nucleic Acids Res       Date:  2014-08-04       Impact factor: 16.971
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  6 in total

1.  Anhydrous Nucleic Acid Nanoparticles for Storage and Handling at Broad Range of Temperatures.

Authors:  Allison N Tran; Morgan Chandler; Justin Halman; Damian Beasock; Adam Fessler; Riley Q McKeough; Phuong Anh Lam; Daniel P Furr; Jian Wang; Edward Cedrone; Marina A Dobrovolskaia; Nikolay V Dokholyan; Susan R Trammell; Kirill A Afonin
Journal:  Small       Date:  2022-02-06       Impact factor: 13.281

2.  The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field.

Authors:  Morgan Chandler; Brittany Johnson; Emil Khisamutdinov; Marina A Dobrovolskaia; Joanna Sztuba-Solinska; Aliasger K Salem; Koen Breyne; Roger Chammas; Nils G Walter; Lydia M Contreras; Peixuan Guo; Kirill A Afonin
Journal:  ACS Nano       Date:  2021-10-22       Impact factor: 18.027

Review 3.  Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs).

Authors:  Weina Ke; Kirill A Afonin
Journal:  Adv Drug Deliv Rev       Date:  2021-06-16       Impact factor: 17.873

4.  2021: an immunotherapy odyssey and the rise of nucleic acid nanotechnology.

Authors:  Martin Panigaj; Marina A Dobrovolskaia; Kirill A Afonin
Journal:  Nanomedicine (Lond)       Date:  2021-06-25       Impact factor: 6.096

Review 5.  Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation.

Authors:  Kirill A Afonin; Marina A Dobrovolskaia; Weina Ke; Piotr Grodzinski; Mark Bathe
Journal:  Adv Drug Deliv Rev       Date:  2021-12-13       Impact factor: 17.873

Review 6.  Current hurdles to the translation of nanomedicines from bench to the clinic.

Authors:  Snežana Đorđević; María Medel Gonzalez; Inmaculada Conejos-Sánchez; Barbara Carreira; Sabina Pozzi; Rita C Acúrcio; Ronit Satchi-Fainaro; Helena F Florindo; María J Vicent
Journal:  Drug Deliv Transl Res       Date:  2021-07-23       Impact factor: 4.617
  6 in total

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