Changsong Liu1, Yanfen Liao2, Zongyuan Zhu3, Lili Yang1, Qin Zhang1, Li Li4,5. 1. Department of Cardiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. 2. Department of Stomatology, The Seventh Affiliated Hospital Sun Yat-Sen University, Shenzhen, 518000, China. 3. Department of Huiqiao Building, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. 4. Department of Cardiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. 650500@hospital.cqmu.edu.cn. 5. The Third Affiliated Hospital of Chongqing Medical University, 1 Shuanghu Branch Road, Yubei District, Chongqing, China. 650500@hospital.cqmu.edu.cn.
Abstract
BACKGROUND: Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents. METHOD: We conducted a cross-sectional analysis of 1242 children and adolescents aged 8-17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, elevated blood pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1-12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13-17 years. Mean serum copper was 114.17 μg/dL. RESULTS: After multiple adjustments, dose-response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval, 2.76-10.03). CONCLUSION: Our results suggested that high serum copper concentrations were significantly associated with EBP in US children and adolescents.
BACKGROUND:Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents. METHOD: We conducted a cross-sectional analysis of 1242 children and adolescents aged 8-17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, elevated blood pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1-12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13-17 years. Mean serum copper was 114.17 μg/dL. RESULTS: After multiple adjustments, dose-response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval, 2.76-10.03). CONCLUSION: Our results suggested that high serum copper concentrations were significantly associated with EBP in US children and adolescents.
Entities:
Keywords:
Children and adolescents; Copper; Dose–response; Elevated blood pressure
Authors: Joseph T Flynn; David C Kaelber; Carissa M Baker-Smith; Douglas Blowey; Aaron E Carroll; Stephen R Daniels; Sarah D de Ferranti; Janis M Dionne; Bonita Falkner; Susan K Flinn; Samuel S Gidding; Celeste Goodwin; Michael G Leu; Makia E Powers; Corinna Rea; Joshua Samuels; Madeline Simasek; Vidhu V Thaker; Elaine M Urbina Journal: Pediatrics Date: 2017-08-21 Impact factor: 7.124
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