BACKGROUND: Copper and zinc are essential trace elements and nutrients, which have important roles in physiology and disease and as cofactors in many metabolic pathways. We established age- and gender-specific reference intervals for serum copper and zinc, with a large healthy pediatric population. METHODS: A total of 2115 clinically healthy children, 85.4% Caucasian, were enrolled: 1098 boys and 1017 girls 0.5-1 8y. Serum copper and zinc concentrations were measured by inductively coupled plasma-mass spectrometry (analytical measurement range: 10-400 μg/dl for each). Statistical analyses and related calculations were performed using the STATA Statistical software and R software. RESULTS: There were no significant effects of gender or fasting status. For copper, but not zinc, there were significant differences in the reference intervals by age. Based on the central 95% and 95% confidence intervals, the resulting reference interval determined for serum zinc was 64-124 μg/dl. The age-dependent reference intervals for serum copper were 75-153 μg/dl for those <10.3 y, 64-132 μg/dl for those 10.3-12.5 y and 57-129 μg/dl for those >12.5 y. CONCLUSIONS: Our data defined reference intervals for serum copper and zinc in an American, clinically healthy, pediatric population.
BACKGROUND:Copper and zinc are essential trace elements and nutrients, which have important roles in physiology and disease and as cofactors in many metabolic pathways. We established age- and gender-specific reference intervals for serum copper and zinc, with a large healthy pediatric population. METHODS: A total of 2115 clinically healthy children, 85.4% Caucasian, were enrolled: 1098 boys and 1017 girls 0.5-1 8y. Serum copper and zinc concentrations were measured by inductively coupled plasma-mass spectrometry (analytical measurement range: 10-400 μg/dl for each). Statistical analyses and related calculations were performed using the STATA Statistical software and R software. RESULTS: There were no significant effects of gender or fasting status. For copper, but not zinc, there were significant differences in the reference intervals by age. Based on the central 95% and 95% confidence intervals, the resulting reference interval determined for serum zinc was 64-124 μg/dl. The age-dependent reference intervals for serum copper were 75-153 μg/dl for those <10.3 y, 64-132 μg/dl for those 10.3-12.5 y and 57-129 μg/dl for those >12.5 y. CONCLUSIONS: Our data defined reference intervals for serum copper and zinc in an American, clinically healthy, pediatric population.
Authors: R Squitti; G Cerchiaro; I Giovannoni; P Francalanci; M Siotto; P Maffei; C Ricordi; M C Rongioletti Journal: CellR4 Repair Replace Regen Reprogram Date: 2019-08-28
Authors: Margarita L Martinez-Fierro; Griselda A Cabral-Pacheco; Idalia Garza-Veloz; Jesus Acuña-Quiñones; Laura E Martinez-de-Villarreal; Marisol Ibarra-Ramirez; Joke Beuten; Samantha E Sanchez-Guerrero; Laura Villarreal-Martinez; Ivan Delgado-Enciso; Iram P Rodriguez-Sanchez; Vania Z Zuñiga-Ramirez; Edith Cardenas-Vargas; Viktor Romero-Diaz Journal: Genes (Basel) Date: 2021-05-14 Impact factor: 4.096
Authors: Marlene Fabiola Escobedo-Monge; Enrique Barrado; Carmen Alonso Vicente; María Antonieta Escobedo-Monge; María Carmen Torres-Hinojal; José Manuel Marugán-Miguelsanz; María Paz Redondo Del Río Journal: Nutrients Date: 2020-10-30 Impact factor: 5.717