Literature DB >> 3350841

Heterogeneity of biotransformation of fluoranthene in perifused liver cells.

A Stier1, A Schlenker, J Sidhu, W Kühnle, S A Finch.   

Abstract

Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of beta-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells.

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Year:  1988        PMID： 3350841     DOI： 10.1007/bf00390484

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  14 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver.

Authors:  M el Mouelhi; F C Kauffman
Journal:  Hepatology       Date:  1986 May-Jun       Impact factor: 17.425

3.  Dynamics of the localization of drug metabolizing enzymes in tissues and cells.

Authors:  C R Wolf; A Buchmann; T Friedberg; E Moll; W D Kuhlmann; H W Kunz; F Oesch
Journal:  Biochem Soc Trans       Date:  1984-02       Impact factor: 5.407

4.  Toxicological studies of liver cells by microspectrofluorometry.

Authors:  A Stier; K H Nolte; A Schlenker; W Schumann; F M Zuretti
Journal:  Arch Toxicol       Date:  1980-03       Impact factor: 5.153

5.  Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule.

Authors:  J G Conway; F C Kauffman; T Tsukada; R G Thurman
Journal:  Mol Pharmacol       Date:  1984-05       Impact factor: 4.436

6.  Intralobular distribution of UDP-glucuronosyltransferase in livers from untreated, 3-methylcholanthrene- and phenobarbital-treated rats.

Authors:  D Ullrich; G Fischer; N Katz; K W Bock
Journal:  Chem Biol Interact       Date:  1984-02       Impact factor: 5.192

7.  Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes.

Authors:  T Shimada; R Sato
Journal:  Biochem Pharmacol       Date:  1979-06-01       Impact factor: 5.858

8.  Microsomal activation of fluoranthene to mutagenic metabolites.

Authors:  J R Babson; S E Russo-Rodriguez; R V Wattley; P L Bergstein; W H Rastetter; H L Liber; B M Andon; W G Thilly; G N Wogan
Journal:  Toxicol Appl Pharmacol       Date:  1986-09-30       Impact factor: 4.219

9.  1,1,1-Trichloropropene-2,3-oxide: an alternate mechanism for its inhibition of cytochrome P-450.

Authors:  K M Ivanetich; M R Ziman; J J Bradshaw
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1982-01

10.  Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay.

Authors:  W F Busby; M E Goldman; P M Newberne; G N Wogan
Journal:  Carcinogenesis       Date:  1984-10       Impact factor: 4.944
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