| Literature DB >> 33503145 |
Armando Menezes-Neto1, Marcia da Costa Castilho2, Guilherme Amaral Calvet3, Edna Oliveira Kara4, Camila Helena Aguiar Bôtto-Menezes5, Marcus Vinícius Guimarães Lacerda6, Gerson Fernando Mendes Pereira7, Silvana Pereira Giozza7, Ximena Pamela Diaz Bermudez8, Noemia Santana Lima9,10, Kayvon Modjarrad10, Nathalie Broutet4, Ana Maria Bispo de Filippis11, Rafael Freitas Oliveira Franca1.
Abstract
We evaluated sweat, blood and urine specimens obtained from an ongoing cohort study in Brazil. Samples were collected at pre-established intervals after the initial rash presentation and tested for Zika virus (ZIKV) RNA presence by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). From 254 participants with confirmed infection, ZIKV RNA was detected in the sweat of 46 individuals (18.1%). Sweat presented a median cycle threshold (Ct) of 34.74 [interquartile range (IQR) 33.44-36.04], comparable to plasma (Ct 35.96 - IQR 33.29-36.69) and higher than urine (Ct 30.78 - IQR 28.72-33.22). Concomitant detection with other specimens was observed in 33 (72%) of 46 participants who had a positive result in sweat. These findings represent an unusual and not yet investigated virus shedding through eccrine glands.Entities:
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Year: 2021 PMID： 33503145 PMCID： PMC7836980 DOI： 10.1590/0074-02760200339
Source DB: PubMed Journal: Mem Inst Oswaldo Cruz ISSN： 0074-0276 Impact factor: 2.743