Vasileios Siokas1, Athina-Maria Aloizou1, Zisis Tsouris1, Ioannis Liampas1, Panagiotis Liakos2, Daniela Calina3, Anca Oana Docea4, Aristidis Tsatsakis5, Dimitrios P Bogdanos6, Georgios M Hadjigeorgiou1,7, Efthimios Dardiotis1. 1. Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece. 2. Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece. 3. Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. 4. Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. 5. Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece. 6. Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece. 7. Department of Neurology, Medical School, University of Cyprus, 1678 Nicosia, Cyprus.
Abstract
BACKGROUND: Parkinson's disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 rs762551 have been linked to PD, to some extent, but the exact role of those polymorphisms in PD remains controversial. OBJECTIVE: We assessed the role of ADORA2A rs5760423 and CYP1A2 rs762551 on PD risk. METHODS: We genotyped 358 patients with PD and 358 healthy controls for ADORA2A rs5760423 and CYP1A2 rs762551. We also merged and meta-analyzed our data with data from previous studies, regarding these two polymorphisms and PD. RESULTS: No significant association with PD was revealed (p > 0.05), for either ADORA2A rs5760423 or CYP1A2 rs762551, in any of the examined genetic model of inheritance. In addition, results from meta-analyses yield negative results. CONCLUSIONS: Based on our analyses, it appears rather unlikely that ADORA2A rs5760423 or CYP1A2 rs762551 is among the major risk factors for PD, at least in Greek patients with PD.
BACKGROUND:Parkinson's disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both ADORA2Ars5760423 and CYP1A2rs762551 have been linked to PD, to some extent, but the exact role of those polymorphisms in PD remains controversial. OBJECTIVE: We assessed the role of ADORA2Ars5760423 and CYP1A2rs762551 on PD risk. METHODS: We genotyped 358 patients with PD and 358 healthy controls for ADORA2Ars5760423 and CYP1A2rs762551. We also merged and meta-analyzed our data with data from previous studies, regarding these two polymorphisms and PD. RESULTS: No significant association with PD was revealed (p > 0.05), for either ADORA2Ars5760423 or CYP1A2rs762551, in any of the examined genetic model of inheritance. In addition, results from meta-analyses yield negative results. CONCLUSIONS: Based on our analyses, it appears rather unlikely that ADORA2Ars5760423 or CYP1A2rs762551 is among the major risk factors for PD, at least in Greek patients with PD.
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