Literature DB >> 33497044

Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.

Mohammad Reza Mirinezhad1, Narges Khosroabadi2, Maliheh Rahpeyma1, Reza Khayami1,3, Seyyed Reza Hashemi1,3, Hamideh Ghazizadeh3,4,5, Gordon A Ferns6, Alireza Pasdar7,8, Majid Ghayour-Mobarhan9,5, Tayebeh Hamzehloei10.   

Abstract

BACKGROUND: Premature menopause is characterized by amenorrhea before age of 40 years, markedly raised serum luteinizing hormone (LH) level, follicle-stimulating hormone (FSH) level and reduced serum level of estradiol. Genome-wide analysis suggested several loci associated with premature menopause. Here, we aimed to analyze association of variants at the MCM8, FNDC4, PRRC2A, TLK1, ZNF346 and TMEM150B gene loci with premature menopause.
MATERIALS AND METHODS: In this cross-sectional study, a total of 117 women with premature menopause were compared to 183 healthy women. Anthropometric indices were measured in all participants: height, weight, body mass index (BMI), waist circumference (WC) and wrist circumference. Eight single-nucleotide polymorphisms (SNPs) of the indicated genes (rs16991615, rs244715, rs451417, rs1046089, rs7246479, rs4806660, rs10183486 and rs2303369) were identified from the literature. Genotyping was performed using tetra-ARMS polymerase chain reaction (PCR) and ASO-PCR methods.
RESULTS: T allele of the rs16991615, rs1046089, rs7246479 and rs10183486, C allele of rs244715, rs451417 and rs4806660 as well as TT genotype of rs2303369 were associated with an increased risk of premature menopause, likely causing susceptibility to primary ovarian insufficiency (POI) in comparison with C allele. We also found an association between the rs16991615 SNP with premature menopause. Frequency of the minor allele in cases was increased for all SNPs in comparison with controls. All minor alleles, except for rs2303369, showed a statistically significant increased odds ratio (OR). However, after Bonferroni correction for multiple testing, none of the P values were remained significant.
CONCLUSION: The selected polymorphisms in MCM8, FNDC4, PRRC2A, TLK1, ZNF346 and TMEM150B genes may potentially affect susceptibility to premature menopause, although replication of the results in larger cohort could clarify this. Copyright© by Royan Institute. All rights reserved.

Entities:  

Keywords:  Association Studies; Genetic Polymorphisms; Haplotype; Premature Menopause

Year:  2021        PMID： 33497044      PMCID： PMC7838752          DOI： 10.22074/ijfs.2020.134688

Source DB:  PubMed          Journal:  Int J Fertil Steril        ISSN： 2008-0778


  36 in total

1.  A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women.

Authors:  Amanda Souza Setti; Sylvia Sanches Cortezzi; Rita de Cássia S Figueira; Ciro Dresch Martinhago; Daniela Paes de Almeida Ferreira Braga; Assumpto Iaconelli; Edson Borges
Journal:  J Assist Reprod Genet       Date:  2012-03-10       Impact factor: 3.412

2.  Minichromosome maintenance complex component 8 (MCM8) gene mutations result in primary gonadal failure.

Authors:  Yardena Tenenbaum-Rakover; Ariella Weinberg-Shukron; Paul Renbaum; Orit Lobel; Hasan Eideh; Suleyman Gulsuner; Dvir Dahary; Amal Abu-Rayyan; Moien Kanaan; Ephrat Levy-Lahad; Dani Bercovich; David Zangen
Journal:  J Med Genet       Date:  2015-04-14       Impact factor: 6.318

3.  Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan.

Authors:  Katherine S Ruth; Ana Luiza G Soares; Maria-Carolina Borges; A Heather Eliassen; Susan E Hankinson; Michael E Jones; Peter Kraft; Hazel B Nichols; Dale P Sandler; Minouk J Schoemaker; Jack A Taylor; Anne Zeleniuch-Jacquotte; Deborah A Lawlor; Anthony J Swerdlow; Anna Murray
Journal:  Hum Mol Genet       Date:  2019-04-15       Impact factor: 6.150

4.  Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors.

Authors:  Michael V Homer; Lindsey M Charo; Loki Natarajan; Carolyn Haunschild; Karine Chung; Jun J Mao; Angela M DeMichele; H Irene Su
Journal:  Menopause       Date:  2017-06       Impact factor: 2.953

5.  Meta-analysis of loci associated with age at natural menopause in African-American women.

Authors:  Christina T L Chen; Ching-Ti Liu; Gary K Chen; Jeanette S Andrews; Alice M Arnold; Jill Dreyfus; Nora Franceschini; Melissa E Garcia; Kathleen F Kerr; Guo Li; Kurt K Lohman; Solomon K Musani; Michael A Nalls; Leslie J Raffel; Jennifer Smith; Christine B Ambrosone; Elisa V Bandera; Leslie Bernstein; Angela Britton; Robert G Brzyski; Anne Cappola; Christopher S Carlson; David Couper; Sandra L Deming; Mark O Goodarzi; Gerardo Heiss; Esther M John; Xiaoning Lu; Loic Le Marchand; Kristin Marciante; Barbara Mcknight; Robert Millikan; Nora L Nock; Andrew F Olshan; Michael F Press; Dhananjay Vaiyda; Nancy F Woods; Herman A Taylor; Wei Zhao; Wei Zheng; Michele K Evans; Tamara B Harris; Brian E Henderson; Sharon L R Kardia; Charles Kooperberg; Yongmei Liu; Thomas H Mosley; Bruce Psaty; Melissa Wellons; Beverly G Windham; Alan B Zonderman; L Adrienne Cupples; Ellen W Demerath; Christopher Haiman; Joanne M Murabito; Aleksandar Rajkovic
Journal:  Hum Mol Genet       Date:  2014-02-02       Impact factor: 6.150

6.  Another DRAM involved in autophagy and cell death.

Authors:  Michaela Mrschtik; Kevin M Ryan
Journal:  Autophagy       Date:  2016       Impact factor: 16.016

7.  DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.

Authors:  John R B Perry; Yi-Hsiang Hsu; Daniel I Chasman; Andrew D Johnson; Cathy Elks; Eva Albrecht; Irene L Andrulis; Jonathan Beesley; Gerald S Berenson; Sven Bergmann; Stig E Bojesen; Manjeet K Bolla; Judith Brown; Julie E Buring; Harry Campbell; Jenny Chang-Claude; Georgia Chenevix-Trench; Tanguy Corre; Fergus J Couch; Angela Cox; Kamila Czene; Adamo Pio D'adamo; Gail Davies; Ian J Deary; Joe Dennis; Douglas F Easton; Ellen G Engelhardt; Johan G Eriksson; Tõnu Esko; Peter A Fasching; Jonine D Figueroa; Henrik Flyger; Abigail Fraser; Montse Garcia-Closas; Paolo Gasparini; Christian Gieger; Graham Giles; Pascal Guenel; Sara Hägg; Per Hall; Caroline Hayward; John Hopper; Erik Ingelsson; Sharon L R Kardia; Katherine Kasiman; Julia A Knight; Jari Lahti; Debbie A Lawlor; Patrik K E Magnusson; Sara Margolin; Julie A Marsh; Andres Metspalu; Janet E Olson; Craig E Pennell; Ozren Polasek; Iffat Rahman; Paul M Ridker; Antonietta Robino; Igor Rudan; Anja Rudolph; Andres Salumets; Marjanka K Schmidt; Minouk J Schoemaker; Erin N Smith; Jennifer A Smith; Melissa Southey; Doris Stöckl; Anthony J Swerdlow; Deborah J Thompson; Therese Truong; Sheila Ulivi; Melanie Waldenberger; Qin Wang; Sarah Wild; James F Wilson; Alan F Wright; Lina Zgaga; Ken K Ong; Joanne M Murabito; David Karasik; Anna Murray
Journal:  Hum Mol Genet       Date:  2013-12-19       Impact factor: 6.150

8.  Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Authors:  Lisette Stolk; John R B Perry; Daniel I Chasman; Chunyan He; Massimo Mangino; Patrick Sulem; Maja Barbalic; Linda Broer; Enda M Byrne; Florian Ernst; Tõnu Esko; Nora Franceschini; Daniel F Gudbjartsson; Jouke-Jan Hottenga; Peter Kraft; Patrick F McArdle; Eleonora Porcu; So-Youn Shin; Albert V Smith; Sophie van Wingerden; Guangju Zhai; Wei V Zhuang; Eva Albrecht; Behrooz Z Alizadeh; Thor Aspelund; Stefania Bandinelli; Lovorka Barac Lauc; Jacques S Beckmann; Mladen Boban; Eric Boerwinkle; Frank J Broekmans; Andrea Burri; Harry Campbell; Stephen J Chanock; Constance Chen; Marilyn C Cornelis; Tanguy Corre; Andrea D Coviello; Pio d'Adamo; Gail Davies; Ulf de Faire; Eco J C de Geus; Ian J Deary; George V Z Dedoussis; Panagiotis Deloukas; Shah Ebrahim; Gudny Eiriksdottir; Valur Emilsson; Johan G Eriksson; Bart C J M Fauser; Liana Ferreli; Luigi Ferrucci; Krista Fischer; Aaron R Folsom; Melissa E Garcia; Paolo Gasparini; Christian Gieger; Nicole Glazer; Diederick E Grobbee; Per Hall; Toomas Haller; Susan E Hankinson; Merli Hass; Caroline Hayward; Andrew C Heath; Albert Hofman; Erik Ingelsson; A Cecile J W Janssens; Andrew D Johnson; David Karasik; Sharon L R Kardia; Jules Keyzer; Douglas P Kiel; Ivana Kolcic; Zoltán Kutalik; Jari Lahti; Sandra Lai; Triin Laisk; Joop S E Laven; Debbie A Lawlor; Jianjun Liu; Lorna M Lopez; Yvonne V Louwers; Patrik K E Magnusson; Mara Marongiu; Nicholas G Martin; Irena Martinovic Klaric; Corrado Masciullo; Barbara McKnight; Sarah E Medland; David Melzer; Vincent Mooser; Pau Navarro; Anne B Newman; Dale R Nyholt; N Charlotte Onland-Moret; Aarno Palotie; Guillaume Paré; Alex N Parker; Nancy L Pedersen; Petra H M Peeters; Giorgio Pistis; Andrew S Plump; Ozren Polasek; Victor J M Pop; Bruce M Psaty; Katri Räikkönen; Emil Rehnberg; Jerome I Rotter; Igor Rudan; Cinzia Sala; Andres Salumets; Angelo Scuteri; Andrew Singleton; Jennifer A Smith; Harold Snieder; Nicole Soranzo; Simon N Stacey; John M Starr; Maria G Stathopoulou; Kathleen Stirrups; Ronald P Stolk; Unnur Styrkarsdottir; Yan V Sun; Albert Tenesa; Barbara Thorand; Daniela Toniolo; Laufey Tryggvadottir; Kim Tsui; Sheila Ulivi; Rob M van Dam; Yvonne T van der Schouw; Carla H van Gils; Peter van Nierop; Jacqueline M Vink; Peter M Visscher; Marlies Voorhuis; Gérard Waeber; Henri Wallaschofski; H Erich Wichmann; Elisabeth Widen; Colette J M Wijnands-van Gent; Gonneke Willemsen; James F Wilson; Bruce H R Wolffenbuttel; Alan F Wright; Laura M Yerges-Armstrong; Tatijana Zemunik; Lina Zgaga; M Carola Zillikens; Marek Zygmunt; Alice M Arnold; Dorret I Boomsma; Julie E Buring; Laura Crisponi; Ellen W Demerath; Vilmundur Gudnason; Tamara B Harris; Frank B Hu; David J Hunter; Lenore J Launer; Andres Metspalu; Grant W Montgomery; Ben A Oostra; Paul M Ridker; Serena Sanna; David Schlessinger; Tim D Spector; Kari Stefansson; Elizabeth A Streeten; Unnur Thorsteinsdottir; Manuela Uda; André G Uitterlinden; Cornelia M van Duijn; Henry Völzke; Anna Murray; Joanne M Murabito; Jenny A Visser; Kathryn L Lunetta
Journal:  Nat Genet       Date:  2012-01-22       Impact factor: 38.330

Review 9.  Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality: A Systematic Review and Meta-analysis.

Authors:  Taulant Muka; Clare Oliver-Williams; Setor Kunutsor; Joop S E Laven; Bart C J M Fauser; Rajiv Chowdhury; Maryam Kavousi; Oscar H Franco
Journal:  JAMA Cardiol       Date:  2016-10-01       Impact factor: 14.676

10.  A genome-wide association study of early menopause and the combined impact of identified variants.

Authors:  John R B Perry; Tanguy Corre; Tõnu Esko; Daniel I Chasman; Krista Fischer; Nora Franceschini; Chunyan He; Zoltan Kutalik; Massimo Mangino; Lynda M Rose; Albert Vernon Smith; Lisette Stolk; Patrick Sulem; Michael N Weedon; Wei V Zhuang; Alice Arnold; Alan Ashworth; Sven Bergmann; Julie E Buring; Andrea Burri; Constance Chen; Marilyn C Cornelis; David J Couper; Mark O Goodarzi; Vilmundur Gudnason; Tamara Harris; Albert Hofman; Michael Jones; Peter Kraft; Lenore Launer; Joop S E Laven; Guo Li; Barbara McKnight; Corrado Masciullo; Lili Milani; Nicholas Orr; Bruce M Psaty; Paul M Ridker; Fernando Rivadeneira; Cinzia Sala; Andres Salumets; Minouk Schoemaker; Michela Traglia; Gérard Waeber; Stephen J Chanock; Ellen W Demerath; Melissa Garcia; Susan E Hankinson; Frank B Hu; David J Hunter; Kathryn L Lunetta; Andres Metspalu; Grant W Montgomery; Joanne M Murabito; Anne B Newman; Ken K Ong; Tim D Spector; Kari Stefansson; Anthony J Swerdlow; Unnur Thorsteinsdottir; Rob M Van Dam; André G Uitterlinden; Jenny A Visser; Peter Vollenweider; Daniela Toniolo; Anna Murray
Journal:  Hum Mol Genet       Date:  2013-01-09       Impact factor: 6.150
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  1 in total

1.  The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study.

Authors:  Mohammad Reza Mirinezhad; Hamideh Ghazizadeh; Maliheh Aghsizadeh; Alireza Pasdar; Majid Ghayour-Mobarhan; Mohammad Zamiri Bidary; Alireza Naghipour; Elahe Hasanzadeh; Mahdiyeh Yaghooti-Khorasani; Ali Ebrahimi Dabagh; Mohammad Reza Shadmand Foumani Moghadam; Nazanin Sheikh Andalibi; Zeynab Naseri Far; Habibollah Esmaily; Gordon A Ferns; Tayebeh Hamzehloei
Journal:  BMC Womens Health       Date:  2022-01-07       Impact factor: 2.809
  1 in total

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