Literature DB >> 3349566

Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination.

M Satoh1, A Naganuma, N Imura.   

Abstract

The protective effects of metallothionein (MT) preinduction by bismuth subnitrate (BSN) against the renal toxicity of cis-diamminedichloroplatinum (cis-DDP), the cardiotoxicity of adriamycin (ADR), and the lethal and bone marrow toxicities of these drugs were observed in mice receiving cis-DDP and ADR simultaneously. Preinduction of MT biosynthesis by BSN, which is currently used as an antidiarrheal drug, did not affect the antitumor activities of the two drugs, suggesting that the beneficial effects of the preinduction of MT biosynthesis by BSN may be applicable for therapy involving cis-DDP and ADR, either alone or in combination.

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Year:  1988        PMID： 3349566     DOI： 10.1007/bf00257369

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  16 in total

1.  A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

Authors:  N R Bachur; S L Gordon; M V Gee
Journal:  Cancer Res       Date:  1978-06       Impact factor: 12.701

2.  Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration.

Authors:  K S Rao; R O Recknagel
Journal:  Exp Mol Pathol       Date:  1968-10       Impact factor: 3.362

3.  Radioresistance in cells with high content of metallothionein.

Authors:  A Bakka; A S Johnsen; L Endresen; H E Rugstad
Journal:  Experientia       Date:  1982-03-15

4.  Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.

Authors:  C Beauchamp; I Fridovich
Journal:  Anal Biochem       Date:  1971-11       Impact factor: 3.365

5.  Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals.

Authors:  P J Thornalley; M Vasák
Journal:  Biochim Biophys Acta       Date:  1985-01-21

6.  Protective effect of zinc against lethality in irradiated mice.

Authors:  J Matsubara; T Shida; K Ishioka; S Egawa; T Inada; K Machida
Journal:  Environ Res       Date:  1986-12       Impact factor: 6.498

7.  Increased resistance to chlorambucil in cultured cells with a high concentration of cytoplasmic metallothionein.

Authors:  L Endresen; A Bakka; H E Rugstad
Journal:  Cancer Res       Date:  1983-06       Impact factor: 12.701

8.  Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.

Authors:  A Naganuma; M Satoh; N Imura
Journal:  Cancer Res       Date:  1987-02-15       Impact factor: 12.701

9.  Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice.

Authors:  A Naganuma; M Satoh; Y Koyama; N Imura
Journal:  Toxicol Lett       Date:  1985 Feb-Mar       Impact factor: 4.372

10.  Inhibition of nitroblue tetrazolium reduction by metallothionein.

Authors:  M Shiraishi; K Utsumi; S Morimoto; I Joja; S Iida; Y Takeda; K Aono
Journal:  Physiol Chem Phys       Date:  1982
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  8 in total

1.  UV-vis absorption spectrum of a novel Ru(II) complex intercalated in DNA: [Ru(2,2'-bipy)(dppz)(2,2'-ArPy)]⁺.

Authors:  Agisilaos Chantzis; Thibaut Very; Stéphane Despax; Jean-Thomas Issenhuth; Alex Boeglin; Pascal Hébraud; Michel Pfeffer; Antonio Monari; Xavier Assfeld
Journal:  J Mol Model       Date:  2014-02-22       Impact factor: 1.810

2.  Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

Authors:  Y J Kang; Y Chen; A Yu; M Voss-McCowan; P N Epstein
Journal:  J Clin Invest       Date:  1997-09-15       Impact factor: 14.808

Review 3.  Cisplatin-induced renal toxicity and toxicity-modulating strategies: a review.

Authors:  V Pinzani; F Bressolle; I J Haug; M Galtier; J P Blayac; P Balmès
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

Review 4.  Metallothionein and anticancer agents: the role of metallothionein in cancer chemotherapy.

Authors:  F Doz; N Roosen; M L Rosenblum
Journal:  J Neurooncol       Date:  1993-08       Impact factor: 4.130

5.  Effect of bismuth nitrate given in combination with cis-diamminedichloroplatinum(II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor.

Authors:  Y Kondo; M Satoh; N Imura; M Akimoto
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

6.  HeLa cell transformants overproducing mouse metallothionein show in vivo resistance to cis-platinum in nude mice.

Authors:  H Toyoda; T Mizushima; M Satoh; N Iizuka; A Nomoto; H Chiba; M Mita; A Naganuma; S Himeno; N Imura
Journal:  Jpn J Cancer Res       Date:  2000-01

7.  Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms.

Authors:  Runming Wang; Suyu Wang; Shing Chan; Yuchuan Wang; Yufeng Zhang; Zhong Zuo; Godfrey Chi-Fung Chan; Hongyan Li; Hongzhe Sun
Journal:  iScience       Date:  2020-04-12

Review 8.  Modulation of cis-diamminedichloroplatinum(II) resistance: a review.

Authors:  H Timmer-Bosscha; N H Mulder; E G de Vries
Journal:  Br J Cancer       Date:  1992-08       Impact factor: 7.640
  8 in total

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