Jian Xiang Wu1,2, Jiang Hui Qing2, Yao Yao2, Dong Yang Chen2, Qing Jiang3. 1. Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, P.R. China. 2. State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, P.R. China. 3. State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, P.R. China. qingj@nju.edu.cn.
Abstract
PURPOSE: To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients. METHODS: We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dimer concentrations were collected before surgery. The D-dimer and age-adjusted D-dimer cut-off was calculated by multiple logistic regression and receiver operating curve (ROC) analyses. RESULTS: A total of 39 patients had found asymptomatic deep vein thrombosis (DVT) by ultrasonography. The age (odds ratio [OR] 1.067; p = 0.003) and D-dimer (OR 1.331; p = 0.025) were related to the existence of DVT. For conventional D-dimer and age-adjusted D-dimer value, the area under the curves (AUCs) were 0.685 (0.499-0.696) and 0.795 (0.611-0.881), respectively. CONCLUSION: Compared to traditional D-dimer, age-adjusted D-dimer showed better performance in screening DVT, which was useful clinically.
PURPOSE: To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients. METHODS: We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dimer concentrations were collected before surgery. The D-dimer and age-adjusted D-dimer cut-off was calculated by multiple logistic regression and receiver operating curve (ROC) analyses. RESULTS: A total of 39 patients had found asymptomatic deep vein thrombosis (DVT) by ultrasonography. The age (odds ratio [OR] 1.067; p = 0.003) and D-dimer (OR 1.331; p = 0.025) were related to the existence of DVT. For conventional D-dimer and age-adjusted D-dimer value, the area under the curves (AUCs) were 0.685 (0.499-0.696) and 0.795 (0.611-0.881), respectively. CONCLUSION: Compared to traditional D-dimer, age-adjusted D-dimer showed better performance in screening DVT, which was useful clinically.
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Authors: Henrike J Schouten; G J Geersing; H L Koek; Nicolaas P A Zuithoff; Kristel J M Janssen; Renée A Douma; Johannes J M van Delden; Karel G M Moons; Johannes B Reitsma Journal: BMJ Date: 2013-05-03
Authors: Jürgen H Prochaska; Bernd Frank; Markus Nagler; Heidrun Lamparter; Gerhard Weißer; Andreas Schulz; Lisa Eggebrecht; Sebastian Göbel; Natalie Arnold; Marina Panova-Noeva; Iris Hermanns; Antonio Pinto; Stavros Konstantinides; Hugo Ten Cate; Karl J Lackner; Thomas Münzel; Christine Espinola-Klein; Philipp S Wild Journal: Sci Rep Date: 2017-07-04 Impact factor: 4.379