Catherine Chiu1, Matthieu Legrand1,2. 1. Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA. 2. F-CRIN INI-CRCT Network, Nancy, France.
Abstract
PURPOSE OF REVIEW: The epidemiology of sepsis and septic shock has been challenging to study for multiple reasons. These include changing diagnostic definitions, as well a high concentration of sepsis-related studies published from high-income countries (HICs), despite a large global burden. This section attempts to address the incidence of sepsis throughout the years and worldwide. RECENT FINDINGS: The incidence of sepsis and septic shock has continued to increase since the first consensus definitions (Sepsis-1) were established in 1991, and the latest definitions (Sepsis-3) provide a better reflection of mortality risk for a diagnosis of sepsis. Several studies argue that the incidence of sepsis is overreported in HICs, based on billing and coding practices, and may lead to overutilization of resources. However, recent estimates of the true global burden of sepsis, including low-income countries, are likely much higher than reported, with calls for better allocation of resources. SUMMARY: The true epidemiology of sepsis worldwide continues to be a highly debated subject, and more research is needed among low-income countries and high-risk subpopulations.
PURPOSE OF REVIEW: The epidemiology of sepsis and septic shock has been challenging to study for multiple reasons. These include changing diagnostic definitions, as well a high concentration of sepsis-related studies published from high-income countries (HICs), despite a large global burden. This section attempts to address the incidence of sepsis throughout the years and worldwide. RECENT FINDINGS: The incidence of sepsis and septic shock has continued to increase since the first consensus definitions (Sepsis-1) were established in 1991, and the latest definitions (Sepsis-3) provide a better reflection of mortality risk for a diagnosis of sepsis. Several studies argue that the incidence of sepsis is overreported in HICs, based on billing and coding practices, and may lead to overutilization of resources. However, recent estimates of the true global burden of sepsis, including low-income countries, are likely much higher than reported, with calls for better allocation of resources. SUMMARY: The true epidemiology of sepsis worldwide continues to be a highly debated subject, and more research is needed among low-income countries and high-risk subpopulations.
Authors: Sidneia Sousa Santos; Milena Karina Coló Brunialti; Larissa de Oliveira Cavalcanti Peres Rodrigues; Ana Maria Alvim Liberatore; Ivan Hong Jun Koh; Vanessa Martins; Francisco Garcia Soriano; Csaba Szabo; Reinaldo Salomão Journal: Biomolecules Date: 2022-06-04
Authors: Jordan C Langston; Michael T Rossi; Qingliang Yang; William Ohley; Edwin Perez; Laurie E Kilpatrick; Balabhaskar Prabhakarpandian; Mohammad F Kiani Journal: Vasc Biol Date: 2022-04-07