Sabrina Jones1,2, Shan Luo1,2,3, Hilary M Dorton2,4, Brendan Angelo1,2, Alexandra G Yunker1,2, John R Monterosso3,4, Kathleen A Page1,2. 1. Division of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. 2. Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. 3. Department of Psychology, University of Southern California, Los Angeles, California, USA. 4. Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
Abstract
OBJECTIVE: The current analysis used functional magnetic resonance imaging (fMRI) to explore a model of energy regulation postulating that the hippocampus integrates interoceptive signals and environmental stimuli to suppress responding to food cues. It was hypothesized that hippocampal activity would increase in response to food cues under postnutritive relative to fasted conditions, given the role of the hippocampus in integrating postnutritive signals with food cues, and that obesity, added sugar intake, or a combination of these factors would alter this response. METHODS: Data were analyzed on 65 participants (29 males). Participants consumed drinks containing 75 g of glucose or water and underwent an fMRI-based food-cue task. Blood-oxygen-level-dependent (BOLD) fMRI was used to examine hippocampal responses to food and nonfood cues. RESULTS: In lean participants, the hippocampal BOLD signal was higher following glucose compared with water, but participants with obesity showed the opposite pattern. BMI interacted with added sugar intake such that BMI was more negatively correlated with hippocampal food-cue reactivity after glucose ingestion in individuals who consumed high levels of added sugar. Hippocampal BOLD was negatively correlated with prospective food intake. CONCLUSIONS: The findings are consistent with the view that energy regulation involves hippocampal processes in humans and that added sugar and excess weight may impair this function.
OBJECTIVE: The current analysis used functional magnetic resonance imaging (fMRI) to explore a model of energy regulation postulating that the hippocampus integrates interoceptive signals and environmental stimuli to suppress responding to food cues. It was hypothesized that hippocampal activity would increase in response to food cues under postnutritive relative to fasted conditions, given the role of the hippocampus in integrating postnutritive signals with food cues, and that obesity, added sugar intake, or a combination of these factors would alter this response. METHODS: Data were analyzed on 65 participants (29 males). Participants consumed drinks containing 75 g of glucose or water and underwent an fMRI-based food-cue task. Blood-oxygen-level-dependent (BOLD) fMRI was used to examine hippocampal responses to food and nonfood cues. RESULTS: In lean participants, the hippocampal BOLD signal was higher following glucose compared with water, but participants with obesity showed the opposite pattern. BMI interacted with added sugar intake such that BMI was more negatively correlated with hippocampal food-cue reactivity after glucose ingestion in individuals who consumed high levels of added sugar. Hippocampal BOLD was negatively correlated with prospective food intake. CONCLUSIONS: The findings are consistent with the view that energy regulation involves hippocampal processes in humans and that added sugar and excess weight may impair this function.
Authors: Zahra Shirzadi; David E Crane; Andrew D Robertson; Pejman J Maralani; Richard I Aviv; Michael A Chappell; Benjamin I Goldstein; Sandra E Black; Bradley J MacIntosh Journal: J Magn Reson Imaging Date: 2015-04-15 Impact factor: 4.813
Authors: Terry L Davidson; Andrea L Tracy; Lindsey A Schier; Susan E Swithers Journal: J Exp Psychol Anim Learn Cogn Date: 2014-07 Impact factor: 2.478
Authors: Tuki Attuquayefio; Richard J Stevenson; Robert A Boakes; Megan J Oaten; Martin R Yeomans; Mehmet Mahmut; Heather M Francis Journal: J Exp Psychol Anim Learn Cogn Date: 2016-09-05 Impact factor: 2.478
Authors: Terry L Davidson; Kinho Chan; Leonard E Jarrard; Scott E Kanoski; Deborah J Clegg; Stephen C Benoit Journal: Hippocampus Date: 2009-03 Impact factor: 3.899
Authors: Ted M Hsu; Vaibhav R Konanur; Lilly Taing; Ryan Usui; Brandon D Kayser; Michael I Goran; Scott E Kanoski Journal: Hippocampus Date: 2014-10-03 Impact factor: 3.899
Authors: Marion A Stopyra; Hans-Christoph Friederich; Sebastian Sailer; Sabina Pauen; Martin Bendszus; Wolfgang Herzog; Joe J Simon Journal: Nutr Neurosci Date: 2019-04-15 Impact factor: 4.994
Authors: Kristi A Clark; Jasmin M Alves; Sabrina Jones; Alexandra G Yunker; Shan Luo; Ryan P Cabeen; Brendan Angelo; Anny H Xiang; Kathleen A Page Journal: Nutrients Date: 2020-03-26 Impact factor: 5.717
Authors: Magen N Lord; Jun-Won Heo; Albino G Schifino; Jessica R Hoffman; Kristen N Donohue; Jarrod A Call; Emily E Noble Journal: Nutrients Date: 2021-11-24 Impact factor: 5.717