Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations.

Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to the overuse of citalopram. The patient had bilateral anterior shoulder dislocation along with right proximal humerus fracture that was occurred during the seizure. The dislocation was initially reduced and then fixed. Moreover, the seizure was controlled with diazepam without any problems, and cardiac monitoring continued for 2 days. Massive citalopram overdose may be associated with recurrent seizures and QT prolongation. Complications postseizures, such as shoulder dislocations, should be examined for and managed appropriately. Copyright:

INTRODUCTION

Citalopram is a selective serotonin reuptake inhibitor (SSRI) that has comparable or greater efficacy than other SSRIs and tricyclic antidepressants (TCAs).[1] Citalopram acts by inhibiting the neuronal reabsorption of serotonin with minimal effect on norepinephrine and dopamine. The usual dose of citalopram is 20–40 mg daily. Overdose of the mentioned drug is associated with symptoms and signs such as dizziness, sweating, nausea, vomiting, tremor, drowsiness, and sinus tachycardia.[2] In previous studies, a generalized seizure was reported in 2%–6% of patients who referred to the hospital following the overdose of citalopram.[34] The onset of seizures may occur within an hour after overdosing or may be delayed up to 13 h later.[56] The mechanism of seizure following citalopram poisoning is unclear; however, a surge increase in cerebral serotonin concentration may be directly responsible in this regard.[3] We describe a case of recurrent seizures following citalopram overdose complicated by bilateral shoulder dislocations and fractures.

CASE REPORT

A 33-year-old male patient presented with a chief complaint of drowsiness referred to the poisoning department of Khorshid Hospital, Isfahan, Iran. He had a history of taking 40 tablets of citalopram (40 mg) an hour before admission to the hospital with the intention of committed suicide. On arrival, he was conscious with a blood pressure of 100 / 70 mmHg, respiratory rate 18/min, heart rate 86 bpm, SpO299% on room air, and temperature 37°C. Other laboratory data (after seizure) are presented in Table 1.

Table 1

Patient’s laboratory data at the time of admission to the toxicological emergencies department

Test name	Value	Test name	Value
Hematology		Biochemistry
WBC, 103/µL	11.2	BUN, mg/dL	10.7
RBC, 106/µL	5.36	Creatinine, mg/dL	1.41
Hemoglobin, g/dL	16.5	AST, IU/L	29
Hematocrit, %	49.5	ALT, IU/L	31
Platelet, 103/µL	298	ALP, IU/L	282
RDW, %	13.1	Sodium Na+, mEq/L	146
MCV, fL	92.4	Potassium, K+, mEq/L	3.8
MCH, pg	30.8	Blood sugar, mg/dL	175
MCHC, g/dL	33.3	Venous blood gas
Coagulation tests		pH	7.04
PTT, s	64	PCO2, mmHg	69.7
PT, s	11.6	PO2, mmHg	38.3
PT control, s	11.5	HCO3−, mEq/L	15.9
INR	1.06	Base excess, mmol/L	−13.1
		O2 saturation, %	49.7

WBC=White blood cell, RBC=Red blood cell, RDW=Red cell distribution width, MCV=Mean corpuscular volume, MCH=Mean corpuscular hemoglobin, MCHC=MCH concentration, PTT=Partial thromboplastin time, PT=Prothrombin time, INR=International normalized ratio, BUN=Blood urea nitrogen, AST=Aspartate aminotransferase, ALT=Alanine aminotransferase, ALP=Alkaline phosphatase test

Shortly after admission, he developed a generalized tonic-clonic seizure that lasted 2 min and resolved without treatment. Nonspecific ST-T changes and prolonged QT interval were observed in the electrocardiogram strip recorded.

After becoming conscious, the nasogastric tube was inserted, and gastric lavage and charcoal therapy were performed. The clinical examination revealed that the right shoulder was dislocated. Portable X-ray were taken, and bilateral anterior shoulder dislocation along with right proximal humerus fracture was confirmed [Figure 1a].

Figure 1

Right proximal humerus fracture dislocation before (a) and after (b) reduction

One hour later, the patient again had a second tonic-clonic seizure that was controlled with diazepam. The patient was sedated and intubated because of decreased level of consciousness, risk of aspiration, and decreased O2 saturation. The patient was transferred to the intensive care unit and underwent mechanical ventilation. Brain computed tomography (CT) scan was done for rule out of central nervous system problem then under sedation, right shoulder dislocation was reduced [Figure 1b].

The brain CT scan was normal. The patient was discharged with full recovery after 2 days and referred to the orthopedic and psychiatric departments for follow-up [Figure 2].

Figure 2

Timeline of the patient's medical status after admission to the toxicological emergencies department

DISCUSSION

In previous studies, seizures were reported in 6% of patients following the overdose of citalopram,[34] but recurrent seizures were very rarely reported. The onset of seizures may occur within an hour after overdosing or may be delayed up to 13 h later.[5] The mechanism of seizure following citalopram poisoning is uncertain. However, a rush in cerebral serotonin concentration may be directly responsible in this regard.[3] The recurrence of seizures may be dose related.

QT prolongation, which may predispose to Torsades de pointes (TdP), can also occur with citalopram overdose. Previous studies suggest that the administration of activated charcoal might help decrease the risk of QT prolongation and subsequent TdP.[5] The proportion of those at risk of TdP (using the QT nomogram) who received activated charcoal was half that of those who did not receive activated charcoal, presumably because of decreased citalopram absorption. Therefore, early activated charcoal may also be useful at decreasing the risk of seizures. However, in our case, a seizure had already occurred, which could reflect the ongoing absorption of the massive citalopram ingestion.

Monitoring should occur for at least 13 h postoverdose for the risk of developing QT prolongation and seizures.

SSRIs are generally safer than older antidepressants, such as TCAs and monoamine oxidase inhibitors. In addition to the low toxicity of SSRIs, their effectiveness in the treatment of many mental disorders has led to their widespread use.[7] However, an overdose of the SSRIs, including citalopram, may be associated with complications such as tachycardia, drowsiness, tremor, nausea, and vomiting.[8]

Cardiac toxicity and seizure were reported as the rare complications of citalopram overdose. Our case had a recurrent seizure, with nonspecific ST-T changes and prolonged QT interval. The patient reported in Cuenca et al.'s study presented with seizure and episode of supraventricular tachycardia following the overdose of citalopram.[5] In 6 cases of fatal citalopram overdose cardiac dysrhythmia or seizure suggested as probable causes of death.[9] In another study, citalopram overdose led to the generalized seizure and cardiac disorder in six patients. Some of the cardiac disorders included prolonged QT interval, transient sinus tachycardia, and inferolateral ST-T changes.[8]

Cuenca et al. stated that seizure incidents increase the need for invasive ventilatory support, secondary trauma, and increase hospital stay.[5] For these complications, patients with citalopram overdose must be observed at least 24 h postingestion.

CONCLUSION

Massive citalopram overdose may be complicated with recurrent seizures and QT prolongation. Complications postseizure consequences, such as shoulder dislocations, should be assessed and managed appropriately. Early administration of activated charcoal should be considered to decrease the risk of toxicity.

Declaration of patient consent

The authors certify that they have obtained appropriate patient consent forms. In the form, the patient has given his consent for his clinical information to be reported. He understood that his name would not be published, and outstanding efforts will be made to conceal his identity.

AUTHORS' CONTRIBUTION

Shafeajafar Zoofaghari and Farzad Gheshlaghi contributed to the idea and design of the study. Shafeajafar Zoofaghari and Pegah Kiarasi gathered the data. Shafeajafar Zoofaghari. Farzad Gheshlaghi and Anselm Wong drafted the manuscript, and all authors critically revised it for relevant intellectual content and approved the final version.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.