Literature DB >> 33489533

A Case of Methyl Ethyl Ketone Peroxide Ingestion Complicated by Rhabdomyolysis.

Abhishek Dhir1, Baldeep Kaur1, Arshi Syal2, Monica Gupta1, Zainab Mehdi1.   

Abstract

Methyl ethyl ketone peroxide (MEKP) is a colorless-to-faintly-yellow liquid that is used as a cross-linking to harden plastics or resins in various industries. It is also an ingredient of paints, varnishes, and paint removers. Because of the high reactivity of MEKP, it is available only as a 40% to 60% solution in dimethyl phthalate or other phthalates. Post-ingestion, the spectrum of complications is vast, ranging from corrosive injury in the oral cavity and gastrointestinal tract to fulminant hepatic toxicity, sepsis, multi-organ failure, and disseminated intravascular coagulation. We report the case of a 40-year-old, self-employed, male worker in a lamination workshop, who presented with accidental ingestion of MEKP from an unlabeled container. He subsequently developed a multitude of complications, most noteworthy being rhabdomyolysis and in turn acute kidney injury. The patient was managed in the intensive care unit with supportive management and hemodialysis sessions; however, the patient succumbed to his illness, despite aggressive measures.
Copyright © 2020, Dhir et al.

Entities:  

Keywords:  acute kidney injury; hemodialysis; mekp; poisoning; rhabdomyolysis

Year:  2020        PMID: 33489533      PMCID: PMC7810179          DOI: 10.7759/cureus.12119

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  12 in total

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Authors:  Xavier Bosch; Esteban Poch; Josep M Grau
Journal:  N Engl J Med       Date:  2009-07-02       Impact factor: 91.245

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Journal:  Lancet       Date:  1976-03-27       Impact factor: 79.321

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Authors:  N Bates; C P Driver; A Bianchi
Journal:  Pediatrics       Date:  2001-08       Impact factor: 7.124

4.  Myoglobin clearance by continuous venous-venous haemofiltration in rhabdomyolysis with acute kidney injury: a case series.

Authors:  Ling Zhang; Yan Kang; Ping Fu; Yu Cao; Yunying Shi; Fang Liu; Zhangxue Hu; Baihai Su; Wanxin Tang; Wei Qin
Journal:  Injury       Date:  2010-09-16       Impact factor: 2.586

5.  Narrowing of airway caused by ingestion of methyl ethyl ketone peroxide.

Authors:  M N Bozdemir; M Yildiz; E S Seyhanli; S Gurbuz; I Kilicaslan; T Karlidag
Journal:  Hum Exp Toxicol       Date:  2011-04-20       Impact factor: 2.903

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Authors:  M V S Subbalaxmi; S Abkari; V R Srinivasan; A Krishnaprasad
Journal:  Natl Med J India       Date:  2010 May-Jun       Impact factor: 0.537

7.  Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides.

Authors:  T Akaike; K Sato; S Ijiri; Y Miyamoto; M Kohno; M Ando; H Maeda
Journal:  Arch Biochem Biophys       Date:  1992-04       Impact factor: 4.013

8.  Modification of hepatic vitamin E stores in vivo. I. Alterations in plasma and liver vitamin E content by methyl ethyl ketone peroxide.

Authors:  D L Warren; D J Reed
Journal:  Arch Biochem Biophys       Date:  1991-02-15       Impact factor: 4.013

9.  A case of severe corrosive esophagitis, gastritis, and liver necrosis caused by ingestion of methyl ethyl ketone peroxide.

Authors:  Jung Oh Chang; Jeong Woo Choi; Yong Hwang
Journal:  Clin Exp Emerg Med       Date:  2016-12-30

10.  A case of methyl ethyl ketone peroxide poisoning and a review of complications and their management.

Authors:  Isurujith K Liyanage; Mitrakrishnan R Navinan; A C A Pathirana; H R I S Herath; Jevon Yudhishdran; Nilesh Fernandopulle; Aruna Kulatunga
Journal:  J Occup Med Toxicol       Date:  2015-07-31       Impact factor: 2.646

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