| Literature DB >> 33489454 |
Mohamed El-Shanshory1,2, Nahed Mohammed Hablas2, Yasmin Shebel2, Osama Alhadramy3, Rehab El-Tahlawi4,5, Moutasem Salih Aboonq6, Tamer M Soliman7, Abdelhady Ragab Abdel-Gawad7, Sayed Mostafa El Sayed8,9, Hesham I Abdallah8,9, Hany Salah Mahmoud10, Hassan El-Allaf11, Samer El-Sawy12, Reda S Yousef12, Mostafa Abu-El Naga13,14, Reham A Mariah15, Manal Mohamed Helmy Nabo16,17, Mohamed Abdel-Haleem18, Ahmed Alamir Mahmoud12, Mohammad Ahmad Hassan19, Areej Hesham Al Arabi20, Abdullah Ahmed Alnakhli20, Salah Mohamed El Sayed1,12,21.
Abstract
Thalassemia is a major health problem in affected children due to iron overload, increased oxidative stress, atherogenic lipid profile and tissue-damage. This study aims at investigating the cardioprotective and tissue-protective benefits of Al-hijamah and their impact on cell-mediated immunity for treating thalassemic children. This study aimed also at investigating the tissue-clearance principle of Taibah mechanism: whenever pathological substances are to be cleared from the human body, Al-hijamah is indicated. Al-hijamah was done to thalassemic children (15 males and 5 females having a mean age of 9.07 ± 4.26 years) using sterile disposable sets in a complete aseptic hospital environment. Prior ethical committee agreement (in addition to written patient's consents) was obtained from Tanta Faculty of Medicine, Egypt. Twenty thalassemic children received iron chelation therapy plus Al-hijamah for one session (30-60 minutes) versus an age and sex-matched thalassemic control group treated with iron chelation therapy only. Al-hijamah is a quite safe outpatient hematological procedure that significantly decreased serum cholesterol (from 129.75 ± 3.67 to 103.5 ± 4.18 mg/dl) and decreased serum triglycerides (from 109.25 ± 8.96 to 91.95 ± 7.22 mg/dl). Interestingly, Al-hijamah exerted significant tissue-protective effects (it decreased serum GPT from 98.65 ± 12.27 to 71.65 ± 32.78 U/L and serum GOT from 96.35 ± 14.33 to 69.35 ± 34.37 U/L). Al-hijamah-induced ferritin excretion caused decreased serum ferritin (high serum ferritin negatively correlated with cell mediated immunity). Al-hijamah exerted cardioprotective and tissue-protective and hypolipidemic effects. Al-hijamah decreased serum cholesterol and is cardioprotective for thalassemic patients as it protects against atherogenesis and atherosclerosis. Medical practice of Al-hijamah is strongly recommended in hospitals. Al-hijamah cleared blood significantly from causative pathological substances e.g. serum ferritin resulting in enhanced cell-mediated immunity (in agreement with the evidence-based Taibah mechanism). AJBREntities:
Keywords: Al-hijamah; Al-hijamah indices; Thalassemia; cholesterol; clearance; iron chelation therapy; liver functions
Year: 2020 PMID： 33489454 PMCID： PMC7811902
Source DB: PubMed Journal: Am J Blood Res ISSN： 2160-1992