BACKGROUND: Beta-thalassaemic patients who usually have a combination of; chronic hemolytic anemia, iron storage disease, myocarditis, and premature death especially due to heart failure may also have increased oxidation of lipids and abnormal lipoprotein concentrations. OBJECTIVE: To determine plasma lipids, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipid peroxidation product malondialdehyde (MDA) in children with β-thalassemia and unaffected control children. Relationships with age, gender, hemoglobin, serum iron, and serum ferritin were examined. Children with β-thalassemia (28 males and 15 females, aged 4 to 18 years) and 31 age- and gender-matched healthy controls were studied. RESULTS: In children with β-thalassemia, there was an increase in TG, MDA, and the MDA/LDL-C ratio (P = .000) and a decrease in TC, LDL-C, HDL-C, and the LDL-C/ TG ratio (P < .001) compared to unaffected controls. The LDL-C/HDL-C ratio was not different. The MDA/LDL-C ratio was correlated negatively with blood hemoglobin and TC (P < .05 for each), whereas the LDL-C/HDL-C ratio was correlated with age, weight, body mass index, and TC (P < .05, < .05, < .05, and < .01 respectively). CONCLUSION: Despite the derangement in plasma lipid profile in children with β-thalassemia accompanied by excess lipid peroxidation, the lipoprotein concentrations do not suggest increased risk. The MDA/LDL-C ratio may prove to be a valuable marker for lipid peroxidation.
BACKGROUND: Beta-thalassaemic patients who usually have a combination of; chronic hemolytic anemia, iron storage disease, myocarditis, and premature death especially due to heart failure may also have increased oxidation of lipids and abnormal lipoprotein concentrations. OBJECTIVE: To determine plasma lipids, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipid peroxidation product malondialdehyde (MDA) in children with β-thalassemia and unaffected control children. Relationships with age, gender, hemoglobin, serum iron, and serum ferritin were examined. Children with β-thalassemia (28 males and 15 females, aged 4 to 18 years) and 31 age- and gender-matched healthy controls were studied. RESULTS: In children with β-thalassemia, there was an increase in TG, MDA, and the MDA/LDL-C ratio (P = .000) and a decrease in TC, LDL-C, HDL-C, and the LDL-C/ TG ratio (P < .001) compared to unaffected controls. The LDL-C/HDL-C ratio was not different. The MDA/LDL-C ratio was correlated negatively with blood hemoglobin and TC (P < .05 for each), whereas the LDL-C/HDL-C ratio was correlated with age, weight, body mass index, and TC (P < .05, < .05, < .05, and < .01 respectively). CONCLUSION: Despite the derangement in plasma lipid profile in children with β-thalassemia accompanied by excess lipid peroxidation, the lipoprotein concentrations do not suggest increased risk. The MDA/LDL-C ratio may prove to be a valuable marker for lipid peroxidation.
Authors: Mohamed El-Shanshory; Nahed Mohammed Hablas; Yasmin Shebel; Osama Alhadramy; Rehab El-Tahlawi; Moutasem Salih Aboonq; Tamer M Soliman; Abdelhady Ragab Abdel-Gawad; Sayed Mostafa El Sayed; Hesham I Abdallah; Hany Salah Mahmoud; Hassan El-Allaf; Samer El-Sawy; Reda S Yousef; Mostafa Abu-El Naga; Reham A Mariah; Manal Mohamed Helmy Nabo; Mohamed Abdel-Haleem; Ahmed Alamir Mahmoud; Mohammad Ahmad Hassan; Areej Hesham Al Arabi; Abdullah Ahmed Alnakhli; Salah Mohamed El Sayed Journal: Am J Blood Res Date: 2020-12-15