Literature DB >> 33488888

Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus.

Ruiqi Tang1, Lanjuan Li1.   

Abstract

In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainly acetate, butyrate, and propionate, the small-molecule metabolites derived from microbial fermentation of indigestible carbohydrates. SCFAs not only have an essential role in intestinal health but might also enter the systemic circulation as signaling molecules affecting the host's metabolism. In this review, we summarize the effects of SCFAs on glucose homeostasis and energy homeostasis and the mechanism through which SCFAs regulate the function of metabolically active organs (brain, liver, adipose tissue, skeletal muscle, and pancreas) and discuss the potential role of modulation of SCFAs as a therapeutic method for T2DM.
Copyright © 2021 Ruiqi Tang and Lanjuan Li.

Entities:  

Year:  2021        PMID： 33488888      PMCID： PMC7801078          DOI： 10.1155/2021/6632266

Source DB:  PubMed          Journal:  Can J Infect Dis Med Microbiol        ISSN： 1712-9532            Impact factor:   2.471


  113 in total

1.  Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes.

Authors:  Julia H Kreznar; Mark P Keller; Lindsay L Traeger; Mary E Rabaglia; Kathryn L Schueler; Donald S Stapleton; Wen Zhao; Eugenio I Vivas; Brian S Yandell; Aimee Teo Broman; Bruno Hagenbuch; Alan D Attie; Federico E Rey
Journal:  Cell Rep       Date:  2017-02-14       Impact factor: 9.423

2.  Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice.

Authors:  V A Matheus; Lcs Monteiro; R B Oliveira; D A Maschio; C B Collares-Buzato
Journal:  Exp Biol Med (Maywood)       Date:  2017-05-15

Review 3.  The role of butyrate, a histone deacetylase inhibitor in diabetes mellitus: experimental evidence for therapeutic intervention.

Authors:  Sabbir Khan; Gopabandhu Jena
Journal:  Epigenomics       Date:  2015       Impact factor: 4.778

4.  Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit.

Authors:  Zhuang Li; Chun-Xia Yi; Saeed Katiraei; Sander Kooijman; Enchen Zhou; Chih Kit Chung; Yuanqing Gao; José K van den Heuvel; Onno C Meijer; Jimmy F P Berbée; Marieke Heijink; Martin Giera; Ko Willems van Dijk; Albert K Groen; Patrick C N Rensen; Yanan Wang
Journal:  Gut       Date:  2017-11-03       Impact factor: 23.059

Review 5.  Emerging therapeutic potential for peptide YY for obesity-diabetes.

Authors:  Ryan A Lafferty; Peter R Flatt; Nigel Irwin
Journal:  Peptides       Date:  2018-02       Impact factor: 3.750

6.  Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors: 
Journal:  Lancet       Date:  2018-11-08       Impact factor: 79.321

7.  Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

Authors:  Jorge Henao-Mejia; Eran Elinav; Chengcheng Jin; Liming Hao; Wajahat Z Mehal; Till Strowig; Christoph A Thaiss; Andrew L Kau; Stephanie C Eisenbarth; Michael J Jurczak; Joao-Paulo Camporez; Gerald I Shulman; Jeffrey I Gordon; Hal M Hoffman; Richard A Flavell
Journal:  Nature       Date:  2012-02-01       Impact factor: 49.962

8.  GPR43 Potentiates β-Cell Function in Obesity.

Authors:  Joanne C McNelis; Yun Sok Lee; Rafael Mayoral; Rik van der Kant; Andrew M F Johnson; Joshua Wollam; Jerrold M Olefsky
Journal:  Diabetes       Date:  2015-05-28       Impact factor: 9.461

9.  Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects.

Authors:  Kec Bouter; G J Bakker; E Levin; A V Hartstra; R S Kootte; S D Udayappan; S Katiraei; L Bahler; P W Gilijamse; V Tremaroli; M Stahlman; F Holleman; N A W van Riel; H J Verberne; J A Romijn; G M Dallinga-Thie; M J Serlie; M T Ackermans; E M Kemper; K Willems van Dijk; F Backhed; A K Groen; M Nieuwdorp
Journal:  Clin Transl Gastroenterol       Date:  2018-05-25       Impact factor: 4.488

10.  Impact of rye-based evening meals on cognitive functions, mood and cardiometabolic risk factors: a randomized controlled study in healthy middle-aged subjects.

Authors:  Jonna C Sandberg; Inger M E Björck; Anne C Nilsson
Journal:  Nutr J       Date:  2018-11-06       Impact factor: 3.271
View more
  7 in total

Review 1.  The Microbiota-Gut-Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect.

Authors:  Fangyuan Zhu; Huaijun Tu; Tingtao Chen
Journal:  Nutrients       Date:  2022-05-16       Impact factor: 6.706

Review 2.  Potential Application of Living Microorganisms in the Detoxification of Heavy Metals.

Authors:  Runqiu Chen; Huaijun Tu; Tingtao Chen
Journal:  Foods       Date:  2022-06-27

3.  [Influence of enteral feeding initiation time on intestinal flora and metabolites in very low birth weight infants: a prospective study].

Authors:  Yu-Jie Shen; Lu-Quan Li; Lu Wei; Xian-Hong Zhang; Wen-Jing Zhao; Xiao-Chen Liu; Li-Ping Wu
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2022-04-15

4.  Daily Inclusion of Resistant Starch-Containing Potatoes in a Dietary Guidelines for Americans Dietary Pattern Does Not Adversely Affect Cardiometabolic Risk or Intestinal Permeability in Adults with Metabolic Syndrome: A Randomized Controlled Trial.

Authors:  Sisi Cao; Emily L Shaw; William R Quarles; Geoffrey Y Sasaki; Priyankar Dey; Joanna K Hodges; Avinash Pokala; Min Zeng; Richard S Bruno
Journal:  Nutrients       Date:  2022-04-08       Impact factor: 6.706

5.  Effects of Stocking Density on Fatty Acid Metabolism by Skeletal Muscle in Mice.

Authors:  Qiuyan Chen; Xiaohui Li; Jiarun Cui; Caiyun Xu; Hongfei Wei; Qian Zhao; Hongli Yao; Hailong You; Dawei Zhang; Huimei Yu
Journal:  Animals (Basel)       Date:  2022-09-22       Impact factor: 3.231

Review 6.  Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells.

Authors:  Elisa Fernández-Millán; Carlos Guillén
Journal:  Biomolecules       Date:  2022-01-08

7.  Activation of the gut microbiota-kynurenine-liver axis contributes to the development of nonalcoholic hepatic steatosis in nondiabetic adults.

Authors:  Guoyuan Sui; Lianqun Jia; Dongmei Quan; Na Zhao; Guanlin Yang
Journal:  Aging (Albany NY)       Date:  2021-09-02       Impact factor: 5.682
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.