Jukka Kiiskilä1,2, Jari Jokelainen3,4, Laura Kytövuori5,6, Ilona Mikkola7, Pirjo Härkönen3,4, Sirkka Keinänen-Kiukaanniemi3,8,9, Kari Majamaa5,6. 1. Research Unit of Clinical Neuroscience, Neurology, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland. jukka.kiiskila@oulu.fi. 2. Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland. jukka.kiiskila@oulu.fi. 3. Center for Life Course Health Research, University of Oulu, Oulu, Finland. 4. Unit of General Practice, Oulu University Hospital, Oulu, Finland. 5. Research Unit of Clinical Neuroscience, Neurology, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland. 6. Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland. 7. Rovaniemi Health Center, Rovaniemi, Finland. 8. Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland. 9. Healthcare and Social Services of Selänne, Pyhäjärvi, Finland.
Abstract
BACKGROUND: We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts. RESULTS: Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p = 0.041), and this finding was more apparent among the best-performing subjects (p < 0.001). CONCLUSIONS: These results suggest that mtDNA haplogroups are one of the genetic determinants explaining individual variability in the adaptive response to endurance training, and mtDNA haplogroups J and K are markers of low-responders in exercise training.
BACKGROUND: We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts. RESULTS: Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p = 0.041), and this finding was more apparent among the best-performing subjects (p < 0.001). CONCLUSIONS: These results suggest that mtDNA haplogroups are one of the genetic determinants explaining individual variability in the adaptive response to endurance training, and mtDNA haplogroups J and K are markers of low-responders in exercise training.
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