Literature DB >> 33479697

Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis.

Brandon T Milliken1, Lindy Melegari1, Gideon L Smith2, Kris Grohn3, Aaron J Wolfe3,4, Kelsey Moody3,4, Fadi Bou-Abdallah2, Robert P Doyle1,5.   

Abstract

Fenretinide is a synthetic retinoid pharmaceutical linked to ceramide build-up in vivo. Saposin D is an intralysosomal protein necessary for ceramide binding/degradation. We show, via electronic absorption spectroscopy, fluorescence spectroscopy, and ceramide hydrolysis assays, that fenretinide is bound by saposin D {K a = (1.45 ± 0.49) × 105 M-1}, and affects ceramide solubilization/degradation. This journal is © The Royal Society of Chemistry 2020.

Entities:  

Year:  2020        PMID： 33479697      PMCID： PMC7513591          DOI： 10.1039/d0md00182a

Source DB:  PubMed          Journal:  RSC Med Chem        ISSN： 2632-8682


  21 in total

1.  EADock: docking of small molecules into protein active sites with a multiobjective evolutionary optimization.

Authors:  Aurélien Grosdidier; Vincent Zoete; Olivier Michielin
Journal:  Proteins       Date:  2007-06-01

Review 2.  Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications.

Authors:  Samy A F Morad; Myles C Cabot
Journal:  Biochim Biophys Acta       Date:  2015-05-09

3.  Interfacial regulation of acid ceramidase activity. Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins.

Authors:  T Linke; G Wilkening; F Sadeghlar; H Mozcall; K Bernardo; E Schuchman; K Sandhoff
Journal:  J Biol Chem       Date:  2000-12-04       Impact factor: 5.157

Review 4.  Mechanism of fenretinide (4-HPR)-induced cell death.

Authors:  J M Wu; A M DiPietrantonio; T C Hsieh
Journal:  Apoptosis       Date:  2001-10       Impact factor: 4.677

5.  Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence spectroscopic study.

Authors:  Amit Kunwar; Atanu Barik; Ruchi Pandey; K Indira Priyadarsini
Journal:  Biochim Biophys Acta       Date:  2006-07-08

6.  Stimulation of acid ceramidase activity by saposin D.

Authors:  N Azuma; J S O'Brien; H W Moser; Y Kishimoto
Journal:  Arch Biochem Biophys       Date:  1994-06       Impact factor: 4.013

7.  Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse.

Authors:  Junko Matsuda; Makiko Kido; Keiko Tadano-Aritomi; Ineo Ishizuka; Kumiko Tominaga; Kazunori Toida; Eiji Takeda; Kunihiko Suzuki; Yasuhiro Kuroda
Journal:  Hum Mol Genet       Date:  2004-09-02       Impact factor: 6.150

8.  Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation.

Authors:  Jay Tinklepaugh; Britannia M Smith; Yan Nie; Kelsey Moody; Kris Grohn; Fadi Bou-Abdallah; Robert P Doyle
Journal:  ChemPhotoChem       Date:  2017-04-13

Review 9.  Acid ceramidase deficiency: Farber disease and SMA-PME.

Authors:  Fabian P S Yu; Samuel Amintas; Thierry Levade; Jeffrey A Medin
Journal:  Orphanet J Rare Dis       Date:  2018-07-20       Impact factor: 4.123

10.  A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors.

Authors:  Isabella Orienti; Federica Francescangeli; Maria Laura De Angelis; Katia Fecchi; Lucilla Bongiorno-Borbone; Michele Signore; Angelo Peschiaroli; Alessandra Boe; Alessandro Bruselles; Angelita Costantino; Adriana Eramo; Valentina Salvati; Giovanni Sette; Paola Contavalli; Lello Zolla; Toshihiko Oki; Toshio Kitamura; Massimo Spada; Alessandro Giuliani; Marta Baiocchi; Filippo La Torre; Gerry Melino; Marco Tartaglia; Ruggero De Maria; Ann Zeuner
Journal:  Cell Death Dis       Date:  2019-07-23       Impact factor: 8.469
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