| Literature DB >> 33479125 |
Gary Reynolds1, Peter Vegh1, James Fletcher1, Elizabeth F M Poyner1,2, Emily Stephenson1, Issac Goh1, Rachel A Botting1, Ni Huang3, Bayanne Olabi1,4, Anna Dubois1,2, David Dixon1, Kile Green1, Daniel Maunder1, Justin Engelbert1, Mirjana Efremova3, Krzysztof Polański3, Laura Jardine1, Claire Jones1, Thomas Ness1, Dave Horsfall1, Jim McGrath1, Christopher Carey1, Dorin-Mirel Popescu1, Simone Webb1, Xiao-Nong Wang1, Ben Sayer1, Jong-Eun Park3, Victor A Negri5, Daria Belokhvostova5, Magnus D Lynch5, David McDonald1, Andrew Filby1, Tzachi Hagai6, Kerstin B Meyer3, Akhtar Husain7, Jonathan Coxhead1, Roser Vento-Tormo3, Sam Behjati3,8, Steven Lisgo1, Alexandra-Chloé Villani9,10, Jaume Bacardit11, Philip H Jones3,12, Edel A O'Toole13, Graham S Ogg14, Neil Rajan1,2, Nick J Reynolds2,15, Sarah A Teichmann16,17, Fiona M Watt18, Muzlifah Haniffa19,2,3.
Abstract
The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.Entities:
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Year: 2021 PMID： 33479125 PMCID： PMC7611557 DOI： 10.1126/science.aba6500
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728