Literature DB >> 33475463

Sufentanil preconditioning protects against myocardial ischemia/reperfusion injury via miR-125a/DRAM2 axis.

Qiaoling Wu1, You Shang1, Yanli Bai1, Yuanyuan Wu1, Hao Wang1, Tu Shen1.   

Abstract

This project aimed to investigate the protective mechanism of sufentanil pretreatment on myocardial ischemia-reperfusion injury (IRI). An in vivo rat model of myocardial IRI and an in vitro cultured cardiomyocyte model of hypoxia-reoxygenation (H/R) were used to confirm the anti-oxidation and anti-autophagy effects of sufentanil. The interaction between miR-125a and damage-regulated autophagy regulator 2 (DRAM2) was verified by luciferase reporter assay. We showed that pretreatment with sufentanil suppressed myocardial damage caused by IRI in rats by inhibiting oxidative stress and mitochondrial autophagy. Furthermore, the cardioprotective mechanism of sufentanil was mediated by miR-125a. MiR-125a targeted DRAM2 to ameliorate cardiomyocyte autophagy and oxidative injury following H/R treatment. In conclusion, our results demonstrated that sufentanil pretreatment produced a protective effect against myocardial IRI via regulating miR-125a/DRAM2 signaling axis.

Entities:  

Keywords:  Ischemia-reperfusion injury; miR-125a; mitochondrial autophagy

Mesh：

Substances：

Year:  2021        PMID： 33475463      PMCID： PMC7894415          DOI： 10.1080/15384101.2021.1875668

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  34 in total

1.  Sufentanil postconditioning protects the myocardium from ischemia-reperfusion via PI3K/Akt-GSK-3β pathway.

Authors:  Qiao-ling Wu; Tu Shen; Hong Ma; Jun-ke Wang
Journal:  J Surg Res       Date:  2012-06-17       Impact factor: 2.192

2.  Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy.

Authors:  Shiyong Wu; Guanglei Chang; Lei Gao; Dan Jiang; Liyou Wang; Guoxing Li; Xuexiu Luo; Shu Qin; Xueli Guo; Dongying Zhang
Journal:  J Mol Med (Berl)       Date:  2018-06-29       Impact factor: 4.599

3.  Effects of morphine and sufentanil preconditioning against myocardial ischemic-reperfusion injury in rabbits.

Authors:  Xiu-Hong Wang; Jian-Feng Zeng; Chao Lin; Shi-Biao Chen
Journal:  Int J Clin Exp Med       Date:  2015-09-15

Review 4.  MicroRNAs in Heart Failure, Cardiac Transplantation, and Myocardial Recovery: Biomarkers with Therapeutic Potential.

Authors:  Palak Shah; Michael R Bristow; J David Port
Journal:  Curr Heart Fail Rep       Date:  2017-12

5.  The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway.

Authors:  Zhen-Hua Chen; Wen-Tao Wang; Wei Huang; Ke Fang; Yu-Meng Sun; Shu-Rong Liu; Xue-Qun Luo; Yue-Qin Chen
Journal:  Cell Death Differ       Date:  2016-10-14       Impact factor: 15.828

6.  miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemia-reperfusion injury.

Authors:  Ignacio Díaz; Eva Calderón-Sánchez; Raquel Del Toro; Javier Ávila-Médina; Eva Sánchez de Rojas-de Pedro; Alejandro Domínguez-Rodríguez; Juan Antonio Rosado; Abdelkrim Hmadcha; Antonio Ordóñez; Tarik Smani
Journal:  Sci Rep       Date:  2017-08-21       Impact factor: 4.379

7.  Sufentanil Preconditioning Protects Against Hepatic Ischemia-Reperfusion Injury by Suppressing Inflammation.

Authors:  Yan-Hong Lian; Jun Fang; Hui-Dan Zhou; Hui-Fang Jiang; Kang-Jie Xie
Journal:  Med Sci Monit       Date:  2019-03-28

8.  miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells.

Authors:  Fangjie Chen; Hong Liu; Jingjing Wu; Yanyan Zhao
Journal:  J Immunol Res       Date:  2018-08-26       Impact factor: 4.818

9.  MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways.

Authors:  Zhebo Liu; Bo Tao; Suzhen Fan; Yong Pu; Hao Xia; Lin Xu
Journal:  Oxid Med Cell Longev       Date:  2019-09-10       Impact factor: 6.543

10.  Sufentanil impairs autophagic degradation and inhibits cell migration in NCI-H460 in vitro.

Authors:  Hui Jiang; Hongxian Wang; Weiwei Zou; Yuexia Hu; Chen Chen; Chunhui Wang
Journal:  Oncol Lett       Date:  2019-10-17       Impact factor: 2.967
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  5 in total

1.  A Systematic Review and Meta-Analysis of Phytoestrogen Protects Against Myocardial Ischemia/Reperfusion Injury: Pre-Clinical Evidence From Small Animal Studies.

Authors:  Yumeng Wang; Xintian Shou; Zongjing Fan; Jie Cui; Donghua Xue; Yang Wu
Journal:  Front Pharmacol       Date:  2022-05-20       Impact factor: 5.988

2.  Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats.

Authors:  Zhen Wang; Xiaoyan Du; Daoyang Yu; Yang Yang; Gaoen Ma; Xueli Jia; Lulu Cheng
Journal:  Eur J Histochem       Date:  2022-01-12       Impact factor: 3.188

3.  Sufentanil alleviates pre-eclampsia via silencing microRNA-24-3p to target 11β-Hydroxysteroid dehydrogenase type 2.

Authors:  Yang Yue; Fu Xu; JiaRong Zhang; Miao Zhao; FangFang Zhou
Journal:  Bioengineered       Date:  2022-05       Impact factor: 6.832

4.  Sufentanil Alleviates Sepsis-Induced Myocardial Injury and Stress Response in Rats through the ERK/GSK-3β Signaling Axis.

Authors:  Hongcheng Zang; Gang Shao; Ying Lou
Journal:  Evid Based Complement Alternat Med       Date:  2022-06-21       Impact factor: 2.650

Review 5.  Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Vesicles and Their Influence on the Heart's Vulnerability to Ischemia-Reperfusion Injury.

Authors:  Miłosz Majka; Marcin Kleibert; Małgorzata Wojciechowska
Journal:  Cells       Date:  2021-11-27       Impact factor: 6.600
  5 in total

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