Palak Shah1, Michael R Bristow2, J David Port2. 1. Department of Heart Failure and Transplantation, Inova Heart and Vascular Institute, 3300 Gallows Road, Falls Church, VA, 22042, USA. Palak.shah@inova.org. 2. Division of Cardiology, Department of Medicine, University of Colorado Denver, Denver, CO, USA.
Abstract
PURPOSE OF REVIEW: Heart failure is increasing in prevalence with a lack of recently developed therapies that produce major beneficial effects on its associated mortality. MicroRNAs are small non-coding RNA molecules that regulate gene expression, are differentially regulated in heart failure, and are found in the circulation serving as a biomarker of heart failure. RECENT FINDINGS: Data suggests that microRNAs may be used to detect allograft rejection in cardiac transplantation and may predict the degree of myocardial recovery in patients with a left ventricular assist device or treated with beta-blocker therapy. Given their role in regulating cellular function, microRNAs are an intriguing target for oligonucleotide therapeutics, designed to mimic or antagonize (antagomir) their biological effects. We review the current state of microRNAs as biomarkers of heart failure and associated conditions, the mechanisms by which microRNAs control cellular function, and how specific microRNAs may be targeted with novel therapeutics designed to treat heart failure.
PURPOSE OF REVIEW: Heart failure is increasing in prevalence with a lack of recently developed therapies that produce major beneficial effects on its associated mortality. MicroRNAs are small non-coding RNA molecules that regulate gene expression, are differentially regulated in heart failure, and are found in the circulation serving as a biomarker of heart failure. RECENT FINDINGS: Data suggests that microRNAs may be used to detect allograft rejection in cardiac transplantation and may predict the degree of myocardial recovery in patients with a left ventricular assist device or treated with beta-blocker therapy. Given their role in regulating cellular function, microRNAs are an intriguing target for oligonucleotide therapeutics, designed to mimic or antagonize (antagomir) their biological effects. We review the current state of microRNAs as biomarkers of heart failure and associated conditions, the mechanisms by which microRNAs control cellular function, and how specific microRNAs may be targeted with novel therapeutics designed to treat heart failure.
Authors: Katrina L Ellis; Vicky A Cameron; Richard W Troughton; Chris M Frampton; Leigh J Ellmers; A Mark Richards Journal: Eur J Heart Fail Date: 2013-05-21 Impact factor: 15.534
Authors: Shelley D Miyamoto; Anis Karimpour-Fard; Valencia Peterson; Scott R Auerbach; Kurt R Stenmark; Brian L Stauffer; Carmen C Sucharov Journal: J Heart Lung Transplant Date: 2015-01-30 Impact factor: 10.247
Authors: Rusty L Montgomery; Thomas G Hullinger; Hillary M Semus; Brent A Dickinson; Anita G Seto; Joshua M Lynch; Christianna Stack; Paul A Latimer; Eric N Olson; Eva van Rooij Journal: Circulation Date: 2011-09-06 Impact factor: 29.690
Authors: Michele Carrer; Ning Liu; Chad E Grueter; Andrew H Williams; Madlyn I Frisard; Matthew W Hulver; Rhonda Bassel-Duby; Eric N Olson Journal: Proc Natl Acad Sci U S A Date: 2012-09-04 Impact factor: 11.205
Authors: Christine Wahlquist; Dongtak Jeong; Agustin Rojas-Muñoz; Changwon Kho; Ahyoung Lee; Shinichi Mitsuyama; Alain van Mil; Woo Jin Park; Joost P G Sluijter; Pieter A F Doevendans; Roger J Hajjar; Mark Mercola Journal: Nature Date: 2014-03-12 Impact factor: 49.962
Authors: Andrew C Morley-Smith; Adam Mills; Steven Jacobs; Bart Meyns; Filip Rega; André R Simon; John R Pepper; Alexander R Lyon; Thomas Thum Journal: Eur J Heart Fail Date: 2014-06-24 Impact factor: 15.534
Authors: L N L Van Aelst; G Summer; S Li; S K Gupta; W Heggermont; K De Vusser; P Carai; M Naesens; J Van Cleemput; F Van de Werf; J Vanhaecke; T Thum; M Waer; A-P Papageorgiou; B Schroen; S Heymans Journal: Am J Transplant Date: 2015-08-06 Impact factor: 8.086
Authors: Till Keller; Jes-Niels Boeckel; Stefan Groß; Jens Klotsche; Lars Palapies; David Leistner; Lars Pieper; Günnter K Stalla; Hendrik Lehnert; Sigmund Silber; David Pittrow; Winfried Maerz; Marcus Dörr; Hans-Ulrich Wittchen; Sebastian E Baumeister; Uwe Völker; Stephan B Felix; Stefanie Dimmeler; Andreas M Zeiher Journal: Sci Rep Date: 2017-07-03 Impact factor: 4.379
Authors: Palak Shah; Sean Agbor-Enoh; Pramita Bagchi; Christopher R deFilippi; Angela Mercado; Gouqing Diao; Dave Jp Morales; Keyur B Shah; Samer S Najjar; Erika Feller; Steven Hsu; Maria E Rodrigo; Sabra C Lewsey; Moon Kyoo Jang; Charles Marboe; Gerald J Berry; Kiran K Khush; Hannah A Valantine Journal: J Heart Lung Transplant Date: 2022-06-28 Impact factor: 13.569